Foxp3<sup>+</sup>cells are running the show in patients with surgically resected nonsmall cell lung cancer

Chaput, Nathalie; Marabelle, Aurélien

doi:10.1183/13993003.01595-2015

Cited by 3 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the combination of Foxp3+TILs and CD8+TILs was significantly associated with DFS. This is consistent with the studies of Chaputetal [ 42 ]. They found that TILs with CD8+ HIGH /Foxp3+ LOW were significantly associated with improved 5y-OS in early stage NSCLC patients.…”

Section: Discussionsupporting

confidence: 94%

Expressions of CD8+TILs, PD-L1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions

et al. 2016

View full text Add to dashboard Cite

PurposeCurrently, adjuvant chemotherapy is recommended for patients with high risk stage I non-small cell lung cancer (NSCLC). However, identifying high risk patients remains a challenge. This study aims to identify the patient cohorts more likely to benefit from adjuvant chemotherapy based on the tumor micro-immune environment.ResultsCD8+TILs significantly associated with disease-free survival (DFS) and overall survial (OS) (p=0.002; 0.040). Patients with high risk factors may also predict shorter DFS (P=0.056). When compared together, patients with high-CD8+TILs showed better DFS than patients with low-CD8+TILs, no matter their risk factors status. There's no correlation between PD-L1 expressions and survival. PD-L1 was highly expressed in men, squamous and well differentiated carcinoma. In addition, Foxp3+TILs alone didn't show any prognostic effects, but low-Foxp3/high-CD8+TILs were associated with prolonged DFS (p=0.031).MethodsA total of 126 patients with surgically resected stage I NSCLC were included to perform immunohistochemistry of CD8+ tumor infiltrating lymphocytes (TILs), programmed death ligand-1(PD-L1) and forkhead box P3 (Foxp3)+TILs.ConclusionCD8+TILs are effective prognostic predictors. Patients with surgically resected stage I NSCLC showing low CD8+TILs could be considered for adjuvant chemotherapy, even if they have no high risk features.

show abstract

Section: Discussionsupporting

confidence: 94%

Expressions of CD8+TILs, PD-L1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Recently, many studies have investigated the clinical significance of tumor‐infiltrating lymphocytes, but few studies have reported the distribution of Tregs in cancer tissues. In lung and colorectal cancer, FOXP3 + cells have been reported to infiltrate both peri‐ and intratumoral areas . In breast cancer, a high number of Tregs within lymphoid infiltrates around the tumor rather than inside the tumor have been shown to be predictive of relapse risk with shorter RFS and OS .…”

Section: Discussionmentioning

confidence: 99%

“…In lung and colorectal cancer, FOXP3 + cells have been reported to infiltrate both peri-and intratumoral areas. 33,34 In breast cancer, a high number of Tregs within lymphoid infiltrates around the tumor rather than inside the tumor have been shown to be predictive of relapse risk with shorter RFS and OS. 35 We compared tumor extent in biopsy specimens between the good and poor prognosis groups to evaluate the effect of tumor volume on the degree of infiltration of CCR4 + Tregs.…”

Section: Discussionmentioning

confidence: 99%

Increased infiltration of CCR4‐positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis

et al. 2019

View full text Add to dashboard Cite

Background Regulatory T cells (Tregs) play important roles in the suppression of immune responses, including antitumor immune responses. C‐C chemokine receptor 4 (CCR4) is highly expressed on effector Tregs, and anti‐CCR4 antibody is attracting attention as a novel immunotherapeutic agent for solid tumors. This study aimed to evaluate the expression of CCR4‐positive Tregs (CCR4+Tregs) in prostate cancer and estimate the clinical potential of CCR4‐targeting therapy for prostate cancer. Methods A total of 15 radical prostatectomy (RP) specimens and 60 biopsy specimens from individuals diagnosed with prostate cancer were analyzed to evaluate the infiltration of CCR4+Tregs in prostate cancer. The relationships between the number of CCR4+Tregs and clinical parameters were investigated in RP and biopsy specimens. Moreover, the total number of Tregs, CCR4+Tregs, and T cells and the ratio of CCR4+Tregs to Tregs and T cells in biopsy specimens were compared between patients with poor prognosis who progressed to castration‐resistant prostate cancer (CRPC) within 12 months (n = 13) and those with good prognosis who were stable with hormone‐sensitive prostate cancer over 12 months (n = 47). Furthermore, biopsy specimens were divided into two groups: low and high CCR4+Treg expression groups and the prognosis was compared between them. Results There was a higher expression of CCR4+Tregs in RP specimens with a higher (≥8) Gleason score than in those with a lower (<8) Gleason score (P = .041). In biopsy specimens, 65.9% Tregs were positive for CCR4. The number of CCR4+Tregs positively correlated with clinical stage (P < .001) and Gleason score (P = .006). The total number of Tregs and CCR4+Tregs significantly increased in the poor prognosis group compared with that in the good prognosis group (P = .024 and .01, respectively). Furthermore, patients with lower CCR4+Treg expression levels showed a significantly longer time to progression to CRPC (not reached vs 27.3 months; P < .001) and median survival time (not reached vs 69.0 months; P = .014) than those with higher expression levels. Conclusions CCR4+Tregs are highly infiltrated in the prostate tissue of patients with poor prognosis with potential to progress to CRPC. Furthermore, the degree of infiltration of CCR4+Tregs is related to the prognosis of prostate cancer.

show abstract

“…Foxp3 is a transcriptional factor of 48 kDa, encoded by the FOX3P gene and characterized by a C-terminal forkhead/winged-helix. This protein domain belongs to a family of DNA-binding factors [19,20] that primarily function in transcriptional inhibition. Foxp3 is expressed in CD4 + CD25 + Tregs and regulates Treg activity via multi-gene control [21,22].…”

Section: Discussionmentioning

confidence: 99%

Significance of Foxp3+CD4+ regulatory T cells in the peripheral blood of Uygur patients in the acute and chronic phases of pigeon breeder’s lung

Yu¹,

Yang²,

Li³

et al. 2017

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

Pigeon breeder's lung (PBL) is a type of lung inflammatory disease associated with the immune response to repeated pigeon-derived antigen exposure. The pathogenesis of PBL remains unclear. In this study, peripheral blood samples were collected from Uygur acute - and chronic-phase PBL patients and healthy subjects with pigeon contact. Foxp3+CD4+ regulatory T cell (Treg) activity in different phases of PBL was characterized by changes in Foxp3+CD4+ Treg, CD4+CD25+ T cell, and T lymphocyte subsets. Based on hypersensitivity pneumonitis (HP) diagnosis criteria, 32 PBL cases from January 2012 to December 2013 in the People's Hospital of Xinjiang Uygur Autonomous Region Respiratory Department were included. Lung high-resolution computed tomography was performed, and the cases were classified based on the HP phase into 15 acute-phase and 17 chronic-phase cases. The control group included 30 healthy subjects with Uygur pigeon contact. Blood samples were collected, and the T cell subsets were analyzed via flow cytometry. In both PBL groups, the Foxp3+CD4+ Treg and CD4+CD25+ and CD4+CD3+ T cell percentages and CD4+/CD8+ ratios were significantly lower than in the control group (p < 0.01). In the PBL groups, particularly the acute-phase group, the CD8+CD3+ T lymphocyte percentage was significantly higher than in the control group (p < 0.01). There were no significant differences in CD4+CD25+ cells between the PBL groups. In peripheral blood from the PBL groups, the CD4+/CD8+ ratio was positively correlated with the Foxp3+CD4+ Treg (r = 0.864, p < 0.05) and CD4+/CD25+ cell (r = 0.34, p < 0.05) percentages. Low Foxp3+CD4+ Treg expression or overconsumption may be a pathogenic factor in PBL.

show abstract

Foxp3⁺cells are running the show in patients with surgically resected nonsmall cell lung cancer

Cited by 3 publications

References 9 publications

Expressions of CD8+TILs, PD-L1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions

Expressions of CD8+TILs, PD-L1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions

Increased infiltration of CCR4‐positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis

Significance of Foxp3+CD4+ regulatory T cells in the peripheral blood of Uygur patients in the acute and chronic phases of pigeon breeder’s lung

Contact Info

Product

Resources

About

Foxp3+cells are running the show in patients with surgically resected nonsmall cell lung cancer

Cited by 3 publications

References 9 publications

Expressions of CD8+TILs, PD-L1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions

Expressions of CD8+TILs, PD-L1 and Foxp3+TILs in stage I NSCLC guiding adjuvant chemotherapy decisions

Increased infiltration of CCR4‐positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis

Significance of Foxp3+CD4+ regulatory T cells in the peripheral blood of Uygur patients in the acute and chronic phases of pigeon breeder’s lung

Contact Info

Product

Resources

About

Foxp3⁺cells are running the show in patients with surgically resected nonsmall cell lung cancer