Fractal dimension analysis of the muscle sympathetic nerve activity

Yambe, Tomoyuki; Nanka, S.; Nitta, S.; Yoshizawa, Makoto; Takayasu, Hisao; Iwase, Satoshi; Mano, T

doi:10.1016/0928-4680(94)90650-5

Cited by 3 publications

(3 citation statements)

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“…We reported that left heart assistance suppressed tension of the sympathetic nerve (10). Recently, the Mayer wave and sympathetic nerve tension relationship was reported by a direct measurement of the human sympathetic nerve (15). The suppression of sympathetic nerve tension is considered to be related to the decrease of the Mayer wave in this experiment.…”

Section: Discussionmentioning

confidence: 85%

Nonlinear Mathematical Analysis of the Hemodynamic Parameters During Left Ventricular Assistance with Oscillated Blood Flow

et al. 1997

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For the development of a totally implantable ventricular assist system (VAS), we have been developing the vibrating flow pump (VFP), which can generate oscillated blood flow with a relatively high frequency (10-50 Hz) for a totally implantable system. In this study, effects of left ventricular assistance with this unique oscillated blood flow were analyzed by nonlinear mathematics for evaluation as the entire circulatory regulatory system, not as a separate part of the system. Left heart bypasses using VFPs from the left atriums to the descending aortas were performed in chronic animal experiments using healthy adult goats. Electrocardiogram (ECG), arterial blood pressure, VFP pump flow, and flow of the descending aorta data taken while the goats were awake were recorded in the data recorder and analyzed in the personal computer system through the AD convertor. Using nonlinear mathematics, time series data were embedded into the phase space, and the Lyapunov numerical method, fractal dimension analysis, and power spectrum analysis were performed to evaluate the nonlinear dynamics. During left ventricular assistance with the VFP, Mayer wave fluctuations were decreased in the power spectrum, the fractal dimension of the hemodynamics was significantly decreased, and peripheral vascular resistance was significantly decreased. These results suggest that nonlinear dynamics, which mediate the cardiovascular dynamics, may be affected during LV bypass with oscillated flow. Decreased power of the Mayer wave in the spectrum caused the limit cycle attractor of the hemodynamics and decreased the peripheral resistance. Decreased sympathetic discharges may be the origin of the decreased Mayer wave and fractal dimension. These nonlinear dynamical analyses may be useful to design the optimal VAS control.

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Section: Discussionmentioning

confidence: 85%

Nonlinear Mathematical Analysis of the Hemodynamic Parameters During Left Ventricular Assistance with Oscillated Blood Flow

et al. 1997

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show abstract

“…Mayer wave fluctuations were thought to be mediated by the sympathetic nervous system because of the experimental use of autonomic blockade, such as beta-blocker administration. In our previous report (9), we suggested that Mayer wave fluctuation may be correlated to the sympathetic tone by recording muscle sympathetic nerve activity in humans. The sympathetic nervous system has been reported to modulate arterial resistance (2,lO).…”

Section: Discussionmentioning

confidence: 98%

Fluctuations of the Hemodynamic Derivatives During Left Ventricular Assistance Using Oscillated Blood Flow

et al. 1996

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To analyze the autonomic nervous system during left heart bypass with a vibrating flow pump (VFP), fluctuations in hemodynamic derivatives were evaluated by the spectral analysis method using fast fourier transform methodology. After the left pleural cavity was opened through the fourth intercostal space under general anesthesia, a VFP was implanted as the left heart bypass device in chronic animal experiments using 3 healthy adult goats. Hemodynamic parameters with and without VFP assistance were recorded on magnetic tape in awake animals and were analyzed by computer through an analog to digital convertor. Power spectral analysis was performed on a beat-to-beat basis for the evaluation of the fluctuations. During left heart bypass with the VFP, Mayer wave fluctuations were decreased significantly although respiratory waves were not changed significantly. These results suggest that sympathetic nervous system modulation was changed under the influences of the left heart bypass with VFP. By using this analysis methodology, truly physiologic ventricular assistance may be achieved.

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“…In 1990, we reported that left heart assistance suppressed tension of the sympathetic nerve ( 10). Recently, the relationship of the Mayer wave and sympathetic nerve tension was reported by a direct measurement of human sympathetic nerve activity ( 15). Tension was considered to be related to a decrease of the Mayer wave in this experiment.…”

Section: Discussionmentioning

confidence: 99%

Chaotic Dynamics in Circulation with Tohoku University Vibrating Flow Pump

et al. 1999

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For the development of a totally implantable ventricular assist system (VAS), we have been developing the vibrating flow pump (VFP), which can generate oscillated blood flow with a relative high frequency (10-50 Hz) for a totally implantable system. In this study, the effects of left ventricular assistance with this unique oscillated blood flow were analyzed by the use of nonlinear mathematics for evaluation as the whole circulatory regulatory system, not as the decomposed parts of the system. Left heart bypasses using the VFP from the left atrium to the descending aorta were performed in chronic animal experiments using healthy adult goats. The ECG, arterial blood pressure, VFP pump flow, and the flow of the descending aorta were recorded in the data recorder during awake conditions and analyzed in a personal computer system through an A-D convertor. By the use of nonlinear mathematics, time series data were embedded into the phase space, the Lyapunov numerical method, fractal dimension analysis, and power spectrum analysis were performed to evaluate nonlinear dynamics. During left ventricular assistance with the VFP, Mayer wave fluctuations were decreased in the power spectrum, the fractal dimension of the hemodynamics was significantly decreased, and peripheral vascular resistance was significantly decreased. These results suggest that nonlinear dynamics, which mediate the cardiovascular dynamics, may be affected during left ventricular (LV) bypass with oscillated flow. The decreased power of the Mayer wave in the spectrum caused the limit cycle attractor of the hemodynamics and decreased peripheral resistance. Decreased sympathetic discharges may be the origin of the decreased Mayer wave and fractal dimension. These nonlinear dynamic analyses may be useful to design optimal VAS control.

show abstract

Fractal dimension analysis of the muscle sympathetic nerve activity

Cited by 3 publications

References 0 publications

Nonlinear Mathematical Analysis of the Hemodynamic Parameters During Left Ventricular Assistance with Oscillated Blood Flow

Nonlinear Mathematical Analysis of the Hemodynamic Parameters During Left Ventricular Assistance with Oscillated Blood Flow

Fluctuations of the Hemodynamic Derivatives During Left Ventricular Assistance Using Oscillated Blood Flow

Chaotic Dynamics in Circulation with Tohoku University Vibrating Flow Pump

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