Fraction of exhaled nitric oxide (<scp>F</scp>e<scp><sub>NO</sub></scp>) norms in healthy North African children 5–16 years old

Rouatbi, Sonia; Alqodwa, Ashraf; Mdella, S. Ben; Saad, Helmi Ben

doi:10.1002/ppul.22721

Cited by 13 publications

(10 citation statements)

References 44 publications

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“…Although the influence of lung function has been described in few studies [22, 25], it was a significant predictor for Fe NO in the present study. In fact, for the included females, MEF 50 (%) and TGV (L) explained a slight but significant Fe NO variability.…”

Section: Discussioncontrasting

confidence: 62%

“…Recently, the Fe NO of a large group of healthy Tunisian/Arab children was prospectively measured [25]. It was shown that the available published children Fe NO norms did not reliably predict Fe NO in this population [25].…”

Section: Introductionmentioning

confidence: 99%

“…It was shown that the available published children Fe NO norms did not reliably predict Fe NO in this population [25]. Thus, a table of normal values according to age ranges was established.…”

Section: Introductionmentioning

confidence: 99%

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Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults

Rouatbi

Chouchène

Sfaxi

et al. 2014

BioMed Research International

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Aims. To establish FeNO norms for healthy Tunisian adults aged 18–60 years and to prospectively assess their reliability. Methods. This was a cross-sectional analytical study. A convenience sample of healthy Tunisian adults was recruited. Subjects responded to a medical questionnaire, and then FeNO levels were measured by an online method (Medisoft, Sorinnes (Dinant), Belgium). Clinical, anthropometric, and plethysmographic data were collected. All analyses were performed on natural logarithm values of FeNO. Results. 257 adults (145 males) were retained. The proposed reference equation to predict FeNO value is lnFeNO (ppb) = 3.47−0.56× height (m). After the predicted FeNO value for a given adult was computed, the upper limit of normal could be obtained by adding 0.60 ppb. The mean ± SD (minimum-maximum) of FeNO (ppb) for the total sample was 13.54 ± 4.87 (5.00–26.00). For Tunisian and Arab adults of any age and height, any FeNO value greater than 26.00 ppb may be considered abnormal. Finally, in an additional group of adults prospectively assessed, we found no adult with a FeNO higher than 26.00 ppb. Conclusion. The present FeNO norms enrich the global repository of FeNO norms that the clinician can use to choose the most appropriate norms.

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Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

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Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults

Rouatbi

Chouchène

Sfaxi

et al. 2014

BioMed Research International

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“…16,17 Since the two groups were matched for the aforementioned parameters, this study’s main finding is not impacted. Moreover, since 21%, 35%, and 53% of Tunisian adolescents had overweight, low socioeconomic level and were qualified as active, 18,19 this study group composition (12%-20% were overweight, 25%-50% had low socioeconomic level, and 57%-60% were active) reflected this “healthy” adolescents population as they exist in the real society, increasing the external validity of this study. Since height is the most important influencing factor of children lung growth, 20 and since the fasters were taller than the non-fasters (Table 1), the spirometric data were standardized with respect to height by applying the local spirometric norms.…”

Section: Population and Methodsmentioning

confidence: 77%

Does Ramadan Fasting Affect Spirometric Data of Healthy Adolescents?

Fraj

Miladi

Guezguez

et al. 2019

Clin Med Insights Pediatr

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Purpose: Several studies raised the effects of Ramadan fasting on healthy adults spirometric data, but none was performed in children. The aim of this study was to compare the spirometric data of a group of faster adolescents (n = 26) with an age-matched non-faster one (n = 10). Methods: This comparative quasi-experimental study, including 36 healthy males aged 12 to 15 years, was conducted during the summer 2015 (Ramadan: June 18 to July 16). Three sessions (Before-Ramadan [Before-R], Mid-Ramadan [Mid-R], After-Ramadan [After-R]) were selected for spirometry measurements. Spirometry was performed around 5.5 to 3.5 h before sunset and the spirometric data were expressed as percentages of local spirometric norms. Results: The two groups of fasters and non-fasters had similar ages and weights (13.35 ± 0.79 vs 12.96 ± 0.45 years, 46.8 ± 9.2 vs 41.7 ± 12.6 kg, respectively). There was no effect of Ramadan fasting on forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, peak expiratory flow, and maximal mid-expiratory flow. For example, during the Before-R, Mid-R, and After-R sessions, there was no significant difference between the fasters and non-fasters mean FVC (101 ± 11 vs 99 ± 14, 101 ± 12 vs 102 ± 14, 103 ± 11 vs 104 ± 13, respectively) or FEV1 (101 ± 13 vs 96 ± 16, 98 ± 11 vs 97 ± 16, 101 ± 10 vs 98 ± 16, respectively). Conclusions: Ramadan fasting had no interaction effect with the spirometric data of Tunisian healthy male adolescents.

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“…However, reports on the relationship between FeNO levels and age compared subjects aged 35–44 years to those aged 64 years and older [18], or between subjects aged less than 60 years to those aged 60 years and older [19]: that is, each group covered a wide age range. Reports on children include a study finding no difference in FeNO level by age in children aged 5–16 years [20], and a study that demonstrated no correlation between FeNO level and age in a group of children aged 8–15 years [21], suggesting that it was highly unlikely that the 1-year difference in age was responsible for the difference in FeNO levels.…”

Section: Discussionmentioning

confidence: 99%

School-aged asthma children with high fractional exhaled nitric oxide levels and lung dysfunction are at high risk of prolonged lung dysfunction

Saito

Kikuchi

Lefor

2019

Asia Pacific Allergy

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BackgroundLong-term management of bronchial asthma based on the fractional exhaled nitric oxide (FeNO) value alone is not conclusive yet. Therefore, we combined FeNO testing and spirometry, a commonly used test in routine practice, to evaluate acute exacerbation and respiratory function in children with bronchial asthma.ObjectiveWe combined FeNO testing and spirometry, commonly used in routine practice, to evaluate acute exacerbations and respiratory function in children with bronchial asthma.MethodsSubjects were school aged children 7 years and older with bronchial asthma who underwent FeNO testing in January 2015 to May 2016. We evaluated the changes in the frequency of acute exacerbations and respiratory function in the 30 subsequent months. Subjects were divided into 2 groups: those with initial FeNO levels ≥ 21 parts per billion (ppb) (high FeNO) and < 20 ppb (normal FeNO) groups.ResultsThere were 48 children (33 boys) in the high FeNO group and 68 children (46 boys) in the normal FeNO group. Spirometry was conducted on 83 children (72%) prior to the initial FeNO test, revealing no difference in the ratio of detecting lung dysfunction between the 2 groups. The observation period was 25.8 ± 0.7 and 24.7 ± 0.6 months for the high and normal FeNO groups, respectively. The children in the high FeNO group with lung dysfunction in the initial FeNO test continued to exhibit lung dysfunction at the test at 30 months. In the normal FeNO group, even if lung dysfunction was observed at the initial FeNO, it improved within the 20-month point, and the improvement was maintained thereafter.ConclusionChildren with bronchial asthma with high FeNO levels and lung dysfunction are at a higher risk of prolonged lung dysfunction.

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Fraction of exhaled nitric oxide (Fe_NO) norms in healthy North African children 5–16 years old

Abstract: Our FeNO norms enrich the global repository of FeNO norms the pediatrician can use to choose the most appropriate norms based on children's location or ethnicity.

Cited by 13 publications

References 44 publications

Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults

Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults

Does Ramadan Fasting Affect Spirometric Data of Healthy Adolescents?

School-aged asthma children with high fractional exhaled nitric oxide levels and lung dysfunction are at high risk of prolonged lung dysfunction

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Fraction of exhaled nitric oxide (FeNO) norms in healthy North African children 5–16 years old

Abstract: Our FeNO norms enrich the global repository of FeNO norms the pediatrician can use to choose the most appropriate norms based on children's location or ethnicity.

Cited by 13 publications

References 44 publications

Fraction of Exhaled Nitric Oxide (FeNO) Norms in Healthy Tunisian Adults

Fraction of Exhaled Nitric Oxide (FeNO) Norms in Healthy Tunisian Adults

Does Ramadan Fasting Affect Spirometric Data of Healthy Adolescents?

School-aged asthma children with high fractional exhaled nitric oxide levels and lung dysfunction are at high risk of prolonged lung dysfunction

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Product

Resources

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Fraction of exhaled nitric oxide (Fe_NO) norms in healthy North African children 5–16 years old

Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults

Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults