Fraction of Exhaled Nitric Oxide and Asthma Predictive Index in Infants Less Than Two Years-Old

The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management

“…FeNO level decreased significantly in the dosage-continued group from 50.9 ppb to 45.0 ppb, and increased significantly in the step-down group from 51.0 ppb to 65.7 ppb. 170 Therefore, FeNO alone is likely insufficient to guide ICS withdrawal. In another study, adults with moderate asthma treated with either budesonide 400 μg plus salmeterol 100 μg or salmeterol/fluticasone 250 at 2 puffs, step down from medium to low dose was safely performed using a combined FeNO and ACT approach at 8 week intervals.…”

Young Infants with Recurrent Wheezing and Positive Asthma Predictive Index Have Higher Levels of Exhaled Nitric Oxide

“…The original study was of a cross-sectional design and was carried out in the pediatric pulmonary clinic at the Hospital Universitario Donostia, Spain (13). Briefly, a consecutive sample of 38 patients aged less than 24 months with recurrent wheezing (three or more episodes of confirmed wheezing in the last year) were enrolled in the study.…”

“…Daily calibration of flow and volume verified the precision of these measurements, as did a calibration of NO to zero. Likewise, the NO gas was calibrated monthly (13).…”

“…Recently, we showed that the determination of online FE NO can be successfully performed in infants (13). Using those data, we conducted this post hoc analysis in order to determine whether recurrent wheezing infants with a positive API (high risk to develop asthma) already had evidence of airway inflammation (as measured by FE NO ) at a young age.…”

Tidal breath eNO measurements in a cohort of unsedated hospitalized neonates—A method validation

“…Measurements of exhaled nitric oxide during tidal breathing in uncooperative infants [22][23][24] have high success rates. 23 The method is easy to execute and has no or minimal impact on the natural breathing pattern of infants when applied during natural sleep.…”