Fractional anisotropy in patients with disproportionately enlarged subarachnoid space hydrocephalus

Radovnický, Tomáš; Adámek, Daniel; Derner, Milouš; Sameš, Martin

doi:10.1007/s00701-016-2861-x

Cited by 9 publications

(21 citation statements)

References 23 publications

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“…Surprisingly, this scenario may be rather common (36.4% of cases in our cohort). This phenomenon has already been described by voxel-based analyses in cases of compressed fiber tracts, for example due to severe hydrocephalus(Radovnický, Adámek, Derner, & Sameš, 2016), and can be extremely misleading in diffusion data analysis, since high FA values are commonly interpreted as markers of WM health.…”

mentioning

confidence: 92%

Along‐tract statistics of neurite orientation dispersion and density imaging diffusion metrics to enhance MR tractography quantitative analysis in healthy controls and in patients with brain tumors

Pieri

Sanvito

Riva

et al. 2020

Human Brain Mapping

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Along‐tract statistics analysis enables the extraction of quantitative diffusion metrics along specific white matter fiber tracts. Besides quantitative metrics derived from classical diffusion tensor imaging (DTI), such as fractional anisotropy and diffusivities, new parameters reflecting the relative contribution of different diffusion compartments in the tissue can be estimated through advanced diffusion MRI methods as neurite orientation dispersion and density imaging (NODDI), leading to a more specific microstructural characterization. In this study, we extracted both DTI‐ and NODDI‐derived quantitative microstructural diffusion metrics along the most eloquent fiber tracts in 15 healthy subjects and in 22 patients with brain tumors. We obtained a robust intraprotocol reference database of normative along‐tract microstructural metrics, and their corresponding plots, from healthy fiber tracts. Each diffusion metric of individual patient's fiber tract was then plotted and statistically compared to the normative profile of the corresponding metric from the healthy fiber tracts. NODDI‐derived metrics appeared to account for the pathological microstructural changes of the peritumoral tissue more accurately than DTI‐derived ones. This approach may be useful for future studies that may compare healthy subjects to patients diagnosed with other pathological conditions.

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mentioning

confidence: 92%

Along‐tract statistics of neurite orientation dispersion and density imaging diffusion metrics to enhance MR tractography quantitative analysis in healthy controls and in patients with brain tumors

Pieri

Sanvito

Riva

et al. 2020

Human Brain Mapping

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“…Sixteen studies 12,22,23,31,32,34,35,38–40,43,47–51 analyzed DTI indices before and after a CSF drainage ( n = 6) 22, 31,32,35,43,48 or a shunt surgery ( n = 10), 12 , 23 , 34 , 38–40 , 47 , 49–51 and correlated them with clinical data.…”

Section: Resultsmentioning

confidence: 99%

“…However, there are some iNPH patients without a DESH appearance and vice versa. 12 The cingulate sulcus sign has also been proposed as an MRI feature of iNPH; it denotes the posterior part of the cingulate sulcus being narrower than the anterior part. 13 Recently, the iNPH Radscale has also become a valuable diagnostic tool, standardized evaluation in the workup in patients with suspected iNPH.…”

Section: Introductionmentioning

confidence: 99%

“…16–17 in 1994, and recently, many papers investigated its role in analyzing white matter (WM) alterations in patients with iNPH. 12 , 18–54 DTI is a non-invasive MR technique that provides information about the orientation and anisotropy of the WM tracts, and may delineate microstructural changes in cerebral WM; high-resolution, multitensor imaging (more than six diffusion directions) is currently combined with various other advanced MR techniques to study connectivity within the brain. In fact, illnesses that disrupt the normal organization or integrity of cerebral WM have a qualitative and quantitative impact on DTI measures.…”

Section: Introductionmentioning

confidence: 99%

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The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review

2020

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Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome that comprises a triad of gait disturbance, dementia and urinary incontinence, associated with ventriculomegaly in the absence of elevated intraventricular cerebrospinal fluid (CSF) pressure. It is important to identify patients with iNPH because some of its clinical features may be reversed by the insertion of a CSF shunt. The diagnosis is based on clinical history, physical examination and brain imaging, especially magnetic resonance imaging (MRI). Recently, some papers have investigated the role of diffusion tensor imaging (DTI) in evaluating white matter alterations in patients with iNPH. DTI analysis in specific anatomical regions seems to be a promising MR biomarker of iNPH and could also be used in the differential diagnosis from other dementias. However, there is a substantial lack of structured reviews on this topic. Thus, we performed a literature search and analyzed the most recent and pivotal articles that investigated the role of DTI in iNPH in order to provide an up-to-date overview of the application of DTI in this setting. We reviewed studies published between January 2000 and June 2020. Thirty-eight studies and four reviews were included. Despite heterogeneity in analysis approaches, the majority of studies reported significant correlations between DTI and clinical symptoms in iNPH patients, as well as different DTI patterns in patients with iNPH compared to those with Alzheimer or Parkinson diseases. It remains to be determined whether DTI could predict the success after CSF shunting.

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“…Diffusion tensor imaging (DTI) is a magnetic resonance (MR) technique that has recently been used to study white matter (WM) degeneration in patients with iNPH. Amongst the DTI parameters, fractional anisotropy (FA) and mean diffusivity (MD) have been demonstrated as a useful index of WM impairment in iNPH patients ( Kanno et al, 2011 ; Nicot et al, 2014 ; Radovnický et al, 2016 ). FA is the most widely used DTI parameter, which reflects the integrity of the axon and is highly sensitive to change in microstructure.…”

Section: Introductionmentioning

confidence: 99%

White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study

et al. 2021

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The present study was designed to systemically evaluate changes in the diffusion tensor imaging (DTI)-derived parameters of iNPH (idiopathic normal pressure hydrocephalus) patients with different responses to the tap test (TT), and to correlate cognitive impairment with white matter (WM) degeneration. This study included 22 iNPH patients and 14 healthy controls with structural magnetic resonance imaging (MRI) and DTI scanning. DTI was used to explore the differences in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for all participants. DTI parameters were evaluated using an ROI (region of interest)-based and tract-based spatial statistics (TBSS) approach. Neuropsychological assessments and the idiopathic normal pressure hydrocephalus grading scoring scale (iNPHGS) were performed. Compared to the TT non-responders, the TT responders group had significantly lower FA values in the corpus callosum, cingulum cingulate gyrus, superior longitudinal fasciculus, and lower AD values in the right cingulum cingulate gyrus and the left posterior thalamic radiation. Besides, the MD values were significantly increased in the corpus callosum, left anterior corona radiata, and the RD values in the corpus callosum and cingulum cingulate gyrus. In addition, the cognitive improvement was negatively correlated with FA of the corpus callosum, cingulum cingulate gyrus, and MD values of the genu of corpus callosum. While, the cognitive improvement was positively related to the AD of the cingulum cingulate gyrus, superior longitudinal, and RD values of the corpus callosum, cingulum cingulate gyrus and uncinate fasciculus. The ROI specific WM lesions in iNPH patients are the underlying basis for cognitive impairment.

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Fractional anisotropy in patients with disproportionately enlarged subarachnoid space hydrocephalus

Cited by 9 publications

References 23 publications

Along‐tract statistics of neurite orientation dispersion and density imaging diffusion metrics to enhance MR tractography quantitative analysis in healthy controls and in patients with brain tumors

Along‐tract statistics of neurite orientation dispersion and density imaging diffusion metrics to enhance MR tractography quantitative analysis in healthy controls and in patients with brain tumors

The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review

White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study

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