2017
DOI: 10.3390/electronics6040106
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Fractional Calculus Based FDTD Modeling of Layered Biological Media Exposure to Wideband Electromagnetic Pulses

Abstract: Electromagnetic fields are involved in several therapeutic and diagnostic applications such as hyperthermia and electroporation. For these applications, pulsed electric fields (PEFs) and transient phenomena are playing a key role for understanding the biological response due to the exposure to non-ionizing wideband pulses. To this end, the PEF propagation in the six-layered planar structure modeling the human head has been studied. The electromagnetic field and the specific absorption rate (SAR) have been calc… Show more

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Cited by 11 publications
(10 citation statements)
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“…Thus, to achieve a quantitative understanding of biological responses, the induced electric field, power density, and the derived dosimetric quantity of specific absorption rate (SAR) as well as the temperature rise inside the tissues have to be quantified and correlated with any observed phenomena. In view of these requirements and considering that the dielectric response of a broad variety of biological media can be described by power‐law in the frequency domain, our fractional calculus‐based FDTD algorithm was extended to incorporate further physics outlined by the Pennes bioheat equation, modeling the heat conduction, metabolism and blood perfusion effects, and the Gagges two‐node model, which takes into account the thermoregulation mechanisms as shivering, regulatory sweating, and vasomotion . A multi‐layered human head structure consisting of skin, fat, bone, dura, CSF, and brain was considered.…”
Section: Special Applicationsmentioning
confidence: 99%
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“…Thus, to achieve a quantitative understanding of biological responses, the induced electric field, power density, and the derived dosimetric quantity of specific absorption rate (SAR) as well as the temperature rise inside the tissues have to be quantified and correlated with any observed phenomena. In view of these requirements and considering that the dielectric response of a broad variety of biological media can be described by power‐law in the frequency domain, our fractional calculus‐based FDTD algorithm was extended to incorporate further physics outlined by the Pennes bioheat equation, modeling the heat conduction, metabolism and blood perfusion effects, and the Gagges two‐node model, which takes into account the thermoregulation mechanisms as shivering, regulatory sweating, and vasomotion . A multi‐layered human head structure consisting of skin, fat, bone, dura, CSF, and brain was considered.…”
Section: Special Applicationsmentioning
confidence: 99%
“…Temperature evolution at the outer surface of the brain layer for a PEF burst characterized by three different hold times. Reproduced under the terms of a Creative Commons Attribution 4.0 International License . Copyright 2017, The Authors, published by MDPI.…”
Section: Special Applicationsmentioning
confidence: 99%
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