Fractional CO2 laser treatment for vulvovaginal atrophy in menopausal women

Simões, Mafalda; Telhado, Conceição; Fraga, Teresa

doi:10.1016/j.maturitas.2019.04.175

Cited by 3 publications

(8 citation statements)

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“…We also observed regression of the signs of vaginal atrophy on colposcopy, as mentioned by Simo ˜es et al 46 Fractional CO2 laser has been shown to be a useful and minimally invasive alternative for the treatment of GSM, 45,47 and it provides advantages over currently available treatments. 46 In particular, it has the convenience of not using creams and produces a longer-lasting effect. The great advantage of this treatment is the absence of immediate or late complications.…”

Section: Discussionsupporting

confidence: 83%

“…It is important to consider that LT is a painless, fast technique with an almost immediate effect and has a prolonged duration when compared with other therapies. 46 Our histomorphometric evaluation demonstrated that the significant increase in the thickness of the VE in both groups equates the efficiency of the LT to the current topical estrogen therapy standard that is recognized as the ''gold standard'' for treating VVA. The increase in SQ-F at the end of treatment in all women demonstrates the impact of VVA on quality of life as well as the importance of its treatment and recovery of physiological conditions of the vagina.…”

Section: Discussionmentioning

confidence: 65%

“…The great advantage of this treatment is the absence of immediate or late complications. It is important to consider that LT is a painless, fast technique with an almost immediate effect and has a prolonged duration when compared with other therapies 46 …”

Section: Discussionmentioning

confidence: 99%

“…3,9,14,23,27,31 Using objective measurements, we observed that both treatments resulted in a significant increase in the thickness of the VE, similar to the findings obtained in previous studies. 9,12,21,45,46 Based on similar protocols 12 for the application of LT and totaling approximately 240 women, some authors demonstrated the effectiveness of fractional CO2 laser in the treatment of VVA, presenting it not only as another option to be offered to the patient, but also as an alternative option as viable as TE. 9,12,21,45,46 Until now, TE was considered more effective for these symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…9,12,21,45,46 Based on similar protocols 12 for the application of LT and totaling approximately 240 women, some authors demonstrated the effectiveness of fractional CO2 laser in the treatment of VVA, presenting it not only as another option to be offered to the patient, but also as an alternative option as viable as TE. 9,12,21,45,46 Until now, TE was considered more effective for these symptoms. However, it is worth mentioning that LT is an onerous procedure, since it is necessary to purchase the machine by the professional as well as it requires adequate training, and thus far, it has not been paid for by health insurers.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of topical fractional CO2 laser and vaginal estrogen for the treatment of genitourinary syndrome in postmenopausal women: a randomized controlled trial

et al. 2021

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Objective: To compare the efficacy of fractional CO2 laser therapy with topical estrogen therapy for the treatment of postmenopausal genitourinary syndrome of menopause. Methods: We conducted a randomized controlled clinical trial involving 25 postmenopausal women. Participants were aged between 50 and 65 years with at least 1 year of amenorrhea and follicle-stimulating hormone levels of >40 IU/L. The women were randomized into two groups: the laser therapy group (n = 13) and the vaginal topical estrogen therapy group (n = 12). Changes in the vaginal epithelium thickness, Frost index, and cell maturation were analyzed in both the groups. The female sexual quotient of each woman was also evaluated. Subjective evaluation was performed through a physical examination. Results: Histological analysis showed a significant increase in the vaginal epithelium thickness at the end of treatment in females in both the laser therapy (P < 0.001) and topical estrogen therapy (P = 0.001) groups. The topical estrogen therapy group tended to present a higher maturation index at the end of treatment when compared with that of the other group. Sexual function increased significantly over time in both the topical estrogen therapy (P < 0.001) and laser therapy (P < 0.001) groups. Subjective evaluation through physical examination showed a significant improvement in atrophy in both the groups. Conclusion: Despite the nonequivalence with topical estrogen therapy, our data suggest that laser therapy is an effective method for the treatment of vulvovaginal atrophy.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of topical fractional CO2 laser and vaginal estrogen for the treatment of genitourinary syndrome in postmenopausal women: a randomized controlled trial

et al. 2021

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A utilização do laser fracionado como tratamento para flacidez e atrofia vulvovaginal / The use of fractional laser as a treatment for laxity and vulvovaginal atrophy

Chagas¹,

Lago²,

Madi³

et al. 2022

Braz. J. Hea. Rev.

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RESUMOO envelhecimento populacional trata-se de uma realidade mundial. Constata-se que as mulheres representam o grupo relacionado com a maior expectativa de vida, sendo afetada diretamente por alterações hormonais ocasionadas com o avançar da idade. O climatério corresponde a um processo fisiológico no qual a mulher passa do período fértil para o não fértil, ao passo que durante essa inversão tem-se um marco designado como menopausa. A menopausa é responsável pela redução da produção de estrogênio decorrente da exaustão dos folículos ovarianos, podendo, portanto, ocasionar transtornos humorais, distúrbios do sono, redução da libido, disfunções uroginecológicas, osteoporose, afecções cardiovasculares e alteração na qualidade de vida da mulher. Diante da variedade sintomatológica, a Síndrome Genitourinária (GSM), termo anteriormente conhecido como atrofia vaginal, inclui não apenas sintomas genitais e sexuais, mas também urinários. Por certo, a atrofia vulvo-vaginal é capaz de alterar o epitélio fazendo com que ele tenha uma consistência mais fina, frágil, pálida sem a presença de rugosidades. O principal tratamento para Atrofia Vulvovaginal, é realizado a partir de drogas estrogênicas, porém apesar de existirem terapêuticas eficazes, diferentes estudos são realizados a fim de se obterem técnicas mais apuradas e não invasivas que consigam tratar de forma segura a atrofia e flacidez vaginal proporcionado o avolumamento da espessura do epitélio estratificado pavimentoso com consequente melhoria da irrigação vascular vaginal. Nesse sentido, a utilização do laser CO2 fracionado insere-se como terapia promissora para tratamento da flacidez e atrofia vulvovaginal devido sua ação térmica e microablativa, proporcionando a reparação funcional e tecidual vaginal.

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A eficácia do laser de Co2 no tratamento da Síndrome Geniturinária na menopausa – uma revisão bibliográfica

De Paula,

Fernandes,

De Oliveira Junior

2023

Braz. J. Hea. Rev.

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A síndrome geniturinária na menopausa é um problema comum em mulheres na pós-menopausa, caracterizada por secura vaginal, coceira e dor durante a relação sexual. O tratamento pode envolver terapia hormonal, mas outros tratamentos, como o uso de laser de CO2 (dióxido de carbono), também podem ser usados. Estudos compararam o laser de CO2 com a terapia hormonal na melhora dos sintomas da síndrome geniturinária na menopausa em 114 mulheres (Sokol, 2017). Estudos demonstraram que tanto os lasers de CO2 quanto a terapia hormonal são eficazes no tratamento dos sintomas, mas os lasers de CO2 têm sido mais bem-sucedidos na redução da dor sexual. Em conclusão, o estudo demonstra que o laser de CO2 é uma opção eficaz para o tratamento das síndromes geniturinárias na menopausa em mulheres. No entanto, mais pesquisas são necessárias para avaliar a eficácia a longo prazo e compará-la com outras opções de tratamento.

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Fractional CO2 laser treatment for vulvovaginal atrophy in menopausal women

Cited by 3 publications

References 0 publications

Comparison of topical fractional CO2 laser and vaginal estrogen for the treatment of genitourinary syndrome in postmenopausal women: a randomized controlled trial

Comparison of topical fractional CO2 laser and vaginal estrogen for the treatment of genitourinary syndrome in postmenopausal women: a randomized controlled trial

A utilização do laser fracionado como tratamento para flacidez e atrofia vulvovaginal / The use of fractional laser as a treatment for laxity and vulvovaginal atrophy

A eficácia do laser de Co2 no tratamento da Síndrome Geniturinária na menopausa – uma revisão bibliográfica

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