2019
DOI: 10.3390/jcm8071026
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Fractional Excretion of Phosphate (FeP) Is Associated with End-Stage Renal Disease Patients with CKD 3b and 5

Abstract: Background: The perturbation of phosphate homeostasis portends unfavorable outcomes in chronic kidney disease (CKD). However, the absence of randomized clinical trials (RCT) fuels the discussion of whether phosphate or some other phosphorous-related factor(s) such as fibroblast growth factor 23 (FGF-23) mediates the cardiovascular and systemic toxicity. We herein test whether the fractional excretion of phosphate (FeP) as a marker of renal stress to excrete phosphorous predicts unfavorable outcomes in CKD pati… Show more

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Cited by 10 publications
(7 citation statements)
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“…Further, FE Pi was higher and TmP/GFR was lower in the patients with CKD compared with healthy controls, which is consistent with the known phosphaturic effects of FGF23 and PTH on remaining functional nephrons to increase fractional phosphorus excretion and decrease the TmP. 12,27,35 A limitation of our study is the inclusion of only one relatively high dietary phosphorus level. We chose a relatively high intake level reflective of a typical United State high-phosphorus diet 23,24 to be translational to real-world patients.…”
Section: Discussionsupporting
confidence: 81%
“…Further, FE Pi was higher and TmP/GFR was lower in the patients with CKD compared with healthy controls, which is consistent with the known phosphaturic effects of FGF23 and PTH on remaining functional nephrons to increase fractional phosphorus excretion and decrease the TmP. 12,27,35 A limitation of our study is the inclusion of only one relatively high dietary phosphorus level. We chose a relatively high intake level reflective of a typical United State high-phosphorus diet 23,24 to be translational to real-world patients.…”
Section: Discussionsupporting
confidence: 81%
“…%TRP was a marker of renal proximal tubular dysfunction and calculated as value of one minus fractional excretion of phosphate. The fractional excretion of phosphate was reported as a possible marker of end-stage renal diseases such as dialysis in moderate to advanced CKD patients [ 21 ]. However, %TRP did not showed continuous change at 6 months after switching to TAF in our study.…”
Section: Discussionmentioning
confidence: 99%
“…In adults, TDF may increase the risk of proximal tubular dysfunction (PTD) among susceptible individuals 4,[11][12][13] . Fractional Excretion of Phosphate (FePO4) is the percentage of glomerular filtered phosphate which is excreted into urine expressed as the ratio of the clearance of phosphate to creatinine clearance 5,14 . Therefore, PTD is associated with elevated urinary excretion of phosphate in the presence of hypophosphatemia 11 .…”
Section: Introductionmentioning
confidence: 99%