The goal of this research is to introduce the simulation studies of the vector-host disease nonlinear system (VHDNS) along with the numerical treatment of artificial neural networks (ANNs) techniques supported by Levenberg-Marquardt backpropagation (LMQBP), known as ANNs-LMQBP. This mechanism is physically appropriate, where the number of infected people is increasing along with the limited health services. Furthermore, the biological effects have fading memories and exhibit transition behavior. Initially, the model is developed by considering the two and three categories for the humans and the vector species. The VHDNS is constructed with five classes, susceptible humans S h (t), infected humans I h (t), recovered humans R h (t), infected vectors I v (t) , and susceptible vector S v (t) based system of the fractional-order nonlinear ordinary differential equations. To solve the number of variations of the VHDNS, the numerical simulations are performed using the stochastic ANNs-LMQBP. The achieved numerical solutions for solving the VHDNS using the stochastic ANNs-LMQBP have been described for training, verifying, and testing data to decrease the mean square error (MSE). An extensive analysis is provided using the correlation studies, MSE, error histograms (EHs), state transitions (STs), and regression to observe the accuracy, efficiency, expertise, and aptitude of the computing ANNs-LMQBP.