Fractionation of Gastric Macromolecular Materials by Electrophoresis, Column Chromatography and Gel Filtration: Correlative Study

Glass, George B. Jerzy

doi:10.1016/b978-0-08-012412-4.50023-1

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…In opposition to some authors [8], the macromolecular materials in the samples were not fractionated (columns, cetylpyridinium, pH variations), but precipitated as a whole. Indeed, the study in a single fraction is convenient for a preliminary physiological study as previously suggested [10,12].…”

Section: Discussion the Significance O F Exlragastric Contaminantsmentioning

confidence: 96%

Stimulation of Gastric Mucous Secretions in Man by Secretin

André¹,

Lambert²,

Descos³

1972

Digestion

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Gastric mucous secretions were collected in fasting patients following a careful gastric washout. The stomach, perfused with saline, was continuously reaspirated. Saliva was obtained separately during the test. Gastric and salivary secretions were collected in four successive 30-min samples. Saline was infused intravenously, alone during the first control period, associated to various doses of secretin during the three following periods: 0 U/kg/h (control series); 0.125 U/kg/h (series II); 0.395 U/kg/h (series III); 1.250 U/kg/h (series IV). The highest dose of secretin induces a sustained increase in the output of fucose, galactose, total hexosamines, uronic acids and sulfate. The variation in the output of mucosubstances aspirated from the human stomach is obtained with doses of secretin smaller than those inducing a maximal response of the exocrine pancreas.

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Section: Discussion the Significance O F Exlragastric Contaminantsmentioning

confidence: 96%

Stimulation of Gastric Mucous Secretions in Man by Secretin

André¹,

Lambert²,

Descos³

1972

Digestion

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“…Many attempts have been made to separate the fractions of gastric mucus using physicochemical methods, but have resulted in incomplete identifi cation of the constituent glycoproteins [5]. H o r o w it z [9] and K en t [11] have therefore suggested that the best overall biochemical picture is obtained by measuring the concentration of the individual carbohydrates in the gastric mucous secretion.…”

mentioning

confidence: 99%

Effect of ACTH on Canine Gastric Mucus

Dickson¹,

Thompson²

1972

Digestion

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It is thought that stress, ACTH and adrenal cortical steroids may be involved in the aetiology of peptic ulceration. Previous work has shown that when ACTH is administered in physiological or therapeutic doses it does not increase gastric acid secretion. We therefore have investigated the effect of ACTH (2 u/kg body wt,) on the ‘mucus barrier’. The volume, weight and concentration of the biochemical constituents of canine gastric mucus were measured before, during and after ACTH administration. No uniform effect of ACTH was detected. Our results differ from those of other workers and the reasons for this are discussed.

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