Stimulation of Gastric Mucous Secretions in Man by Secretin

Abstract

Gastric mucous secretions were collected in fasting patients following a careful gastric washout. The stomach, perfused with saline, was continuously reaspirated. Saliva was obtained separately during the test. Gastric and salivary secretions were collected in four successive 30-min samples. Saline was infused intravenously, alone during the first control period, associated to various doses of secretin during the three following periods: 0 U/kg/h (control series); 0.125 U/kg/h (series II); 0.395 U/kg/h (series III); 1.250 U/kg/h (series IV). The highest dose of secretin induces a sustained increase in the output of fucose, galactose, total hexosamines, uronic acids and sulfate. The variation in the output of mucosubstances aspirated from the human stomach is obtained with doses of secretin smaller than those inducing a maximal response of the exocrine pancreas.

Dose-Response Curve to Secretin on Gastric Mucus Secretion in Conscious Cats

“…Since we did not try to eliminate duodenal reflux of bile or pancreatic juice and saliva swallowing from GF, the results obtained in HP in which no contamination can occur, are more reliable. With careful collection of gastric juice in man, using a gastric infusion-aspiration system, the effect of secretin has been confirmed in the innervated stomach [1],…”

Effect of Secretin on Mucinous Secretion by the Isolated Canine Stomach Perfused Extracorporeally

“…Secretin produced stimulation of both glycoprotein and polysaccharide fractions (8,9). André et al (7) found, in man, that secretin induced a sustained increase in the output of fucose, galactose, total hexosamines, uronic acid and sulfate. They did not use pentagastrin but assessed the effect of secretin on nonstimulated gastric secretion (7).…”

“…André et al (7) found, in man, that secretin induced a sustained increase in the output of fucose, galactose, total hexosamines, uronic acid and sulfate. They did not use pentagastrin but assessed the effect of secretin on nonstimulated gastric secretion (7). Previous studies (7 -9 ) did not use the gas chromatography procedure for analysis of mucinous components.…”

“…Mucin produc tion by gastric mucosa has been investigated in clinical conditions and in experimental animals, in vivo (1 -10) and under ex vivo (11,12) conditions. Gastric mucus secretion can be stimulated by secretin, in man (7) and in cats (8,9). Secretin is a known inhibitor of gastric acid secretion and an effective stimulant of gastric pepsin, both in vivo (13) and under ex vivo conditions (14).…”

Influence of Secretin on Salivary Mucous Secretion in Man

“…Secretin increases gastric mucous secretion in man [1] and the cat [12] but not in the dog [13] and the rat [11]. One may assume that species dif ferences could atïect the physiology of gastric glycoproteins.…”