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SUMMARY This paper presents evidence for the existence in extracts from porcine non-antral gastric tissue of a peptide capable of causing substantial rises of plasma immunoreactive gastrin levels in a dose dependent manner and of stimulation of gastric acid and pepsin secretion. Obtained data show that the peptide is basic and that its gastrin releasing properties are at least partially resistant to atropinisation and #-receptor blockade. Antrectomy almost eliminates the rise in plasma IRGa when the peptide is administered. The possible relationship of this peptide to amphibian bombesin is discussed.

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The effect of secretin on gastric mucus was studied simultaneously with acid and pepsin secretions in three conscious cats with gastric fistula and Heidenhain pouch. The glycoprotein fraction of mucus was estimated by fucose and galactose concentration and the polysaccharide fraction by uronic acid concentration in homogenized gastricjuice. Secretin produced stimulation of both fractions which persisted during continuous infusion and was proportional to the doses. However, this action was greater on the polysaccharide than on the glycoprotein fraction and the variations of pepsin and uronic acids were strongly correlated. Secretin stimulates mucus secretion when no parietal stimulation is induced.