I would like to thank my supervisor for the possibility to engage in this path, for the patient presence and professional assistance. I deeply enjoyed the journey. Journey worth pursuing even more for the companions I met in my research group, especially Pablo. I am grateful to Stuart, Ciça, Carlos, Kris and Jenifer for assistance in my inner work. I owe to the love found here in Brazil: Marcinha and Roba, Renata and Ananda, Cata, as Gumietes, Marcos, Rubens. To the strong family that made this possible. And finally to my chosen family, my friends spread all over. All of you make my life truly rich and prosperous. I dedicate this work to Rossella: "Domani é un altro giorno." This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES)-Finance Code 001. I would like to thank the CPG and FISMAT secretary, all the caretakers and workers at USP.