Fracturas costales simétricas asociadas a tos

Trovato, Daiana; Sousa, Jorge E. de; Bruetman, Julio E; Finn, Bárbara C; Young, Pablo

doi:10.4067/s0034-98872018000300391

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Анализ результатов инструментальных методов обследования пациентов, в частности суточного мониторирования АД, показал статистически значимые различия показателей среднего систолического, дневного систолического и дневного диастолического АД у пациентов бронхоспазма и не купируется противокашлевыми препаратами центрального действия [15]. Кроме того, кашель способен вызвать рвоту, охриплость голоса, недержание мочи в момент приступа, пневмоторакс, переломы ребер и грыжи [15][16][17]. Возникновение данной НР ухудшает качество повседневной жизни пациентов с кардиоваскулярной патологией.…”

Section: результатыunclassified

Clinical Signs and Medical History as Predictors of Enalapril-Associated Dry Cough in Cardiovascular Patients

Сычев

Denisenko²,

Качанова³

et al. 2023

Bezopasnost' i risk farmakoterapii

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Angiotensin-converting enzyme inhibitors (ACEIs) are among the most prescribed and effective medicinal products for the treatment of several cardiovascular diseases. According to a number of studies, 30% of patients taking ACEIs develop adverse drug reactions (ADRs), and treatment discontinuation is often required as a result. The most common ADR associated with ACEIs is a dry (non-productive) cough. Nevertheless, the clinical signs and medical history predictive of this ADR in cardiovascular patients are still understudied.The aim of the study was to analyse the clinical signs and medical history predictive of cough in patients with cardiovascular conditions treated with enalapril.Materials and methods. The study was carried out in 2019–2022 and enrolled 224 patients with essential hypertension (grades 2 and 3) treated with enalapril at a dose of 10–20 mg/day. The patients were assigned to 2 groups: Group 1 included 113 patients with enalapril-associated cough, while Group 2 (control group) comprised 104 patients without this ADR. At screening, all the patients underwent a general examination and a check of their allergy and medication history. Using the data obtained, the authors analysed the association of the clinical signs and medical history with the ADR of interest (dry cough).Results. In contrast to the control group, the group with ACEI-associated dry cough included more patients with a history of drug-induced toxicoderma (OR=5.639, CI 2.234–14.236, χ2=15.845, and p<0.001) or type 2 diabetes mellitus (OR=3.409, CI 1.461–7.953, χ2=8.7472, and p<0.01), a family history of bronchial asthma (OR=4.141, CI 2.066–8.299, χ2=17.417, and p<0.001), and a close family history of severe allergic reactions (OR=3.714, CI 1.720– 8.018, χ2=12.137, and p<0.001).Conclusions. A family history of allergy increases the probability of dry cough in patients taking ACEIs. In order to improve the safety of ACEI therapy, patients with cardiovascular conditions should be asked more detailed questions about their personal or first-degree family history of allergy.

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Section: результатыunclassified

Clinical Signs and Medical History as Predictors of Enalapril-Associated Dry Cough in Cardiovascular Patients

Сычев

Denisenko²,

Качанова³

et al. 2023

Bezopasnost' i risk farmakoterapii

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“…Coughing is considered an important physiological defense mechanism that is often self-limited and uncomplicated. However, when severe, it can be associated with pneumothorax, pulmonary herniation, or rib fractures 1,2 . Most commonly, rib fractures are caused by a thoracic injury.…”

Section: Introductionmentioning

confidence: 99%

Cough-Induced Rib Fracture in a Healthy Woman: A Case Report

Tanja,

Kristina,

Marina

et al. 2024

MCCRJ

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“…Coughing is often self-limited and uncomplicated. However, when severe, it can be associated with pneumothorax, pulmonary herniation, or rib fractures [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cough-induced rib fracture in a smoker: a case report

Daccache¹,

Haddad²,

Ghanem³

et al. 2020

J Med Case Reports

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Background: Coughing is considered an important mechanism that helps the body get rid of foreign substances or prevent their entry into the tracheobronchial tree. Infrequently, after the onset of coughing, patients presenting with persistent chest pain are found to have rib fractures. Among the cases reported for cough-induced rib fractures, the maximum number of fractured ribs was found to be four. Case presentation: In this report, we present a case of a healthy 50-year-old Lebanese smoker who developed a total of six fractures in five ribs, asymmetrically, after coughing for 2.5 months. Conclusion: This case report is, to our knowledge, the first to describe six cough-induced rib fractures in a smoker without an underlying predisposition.

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Fracturas costales simétricas asociadas a tos

Cited by 5 publications

References 12 publications

Clinical Signs and Medical History as Predictors of Enalapril-Associated Dry Cough in Cardiovascular Patients

Clinical Signs and Medical History as Predictors of Enalapril-Associated Dry Cough in Cardiovascular Patients

Cough-Induced Rib Fracture in a Healthy Woman: A Case Report

Cough-induced rib fracture in a smoker: a case report

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