Fracture History in Osteoporosis: Risk Factors and its Effect on Quality of Life

Kuru, Pinar; Akyüz, Gülseren; Cerşit, Hülya Peynirci; Celenlioglu, Alp Eren; Cumhur, Ahmet; Biricik, Şefikcan; Kozan, Seda; Gökşen, Aylin; Özdemi̇r, Mi̇kai̇l; Lüleci, Nimet Emel

doi:10.5152/balkanmedj.2014.13265

Cited by 20 publications

(16 citation statements)

References 15 publications

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“…The multiple linear regression results indicated that sex, age, race, previous fracture, BMI, smoking, and physical activity are significant for T2DM patients 6 , 8 , 27 , 29 – 35 , 44 – 48 . Thus these related risk factors might partially contribute to the declining trend in mean BMD.…”

Section: Discussionmentioning

confidence: 95%

“…For the race/ethnicity groups, “Mexican American” and “Other Hispanic” were merged into a single group called “Hispanic,” and the remaining groups were “non-Hispanic White,” “non-Hispanic Black,” and “non-Hispanic other,” respectively. BMD-related variables, including body mass index (BMI), previous fracture 29 , 30 , smoking status 31 , 32 , physical activity 33 , 34 , and family history of osteoporosis 35 , were considered for analysis. BMI was derived from measured weight in kilograms, divided by the square of height in meters.…”

Section: Methodsmentioning

confidence: 99%

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Trends in osteoporosis and mean bone density among type 2 diabetes patients in the US from 2005 to 2014

2021

Sci Rep

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This study aimed to examine how bone health changed among T2DM patients in the past decade. Continuous National Health and Nutrition Examination Survey (NHANES) data from 2005–2006 to 2013–2014 were analyzed to examine the trends of bone mineral density (BMD) and the prevalence trends of osteoporosis osteopenia among T2DM patients and non-diabetic people aged 40 years and older. The age- and BMI-adjusted mean BMD of the femur neck for the four NHANES cycles decreased linearly in both T2DM patients and non-diabetic people (both Plinear trend ≤ 0.009). Among women with T2DM, the mean BMD in 2013–2014 was significantly lower than that in 2005–2006, even after adjusting for multiple covariates. During 2005–2014, the prevalence of osteoporosis among T2DM patients and non-diabetic people increased but with no significant linear trend (both Plinear trend > 0.05), while the prevalence of osteopenia in the two populations increased linearly (both Plinear trend < 0.04). Age- and BMI-adjusted mean BMD decreased in 2013–2014 in patients with T2DM and non-diabetic people, while the prevalence of osteoporosis and osteopenia increased in both groups.

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Section: Discussionmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

Trends in osteoporosis and mean bone density among type 2 diabetes patients in the US from 2005 to 2014

2021

Sci Rep

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“…Incidence of cardiovascular and cerebrovascular diseases such as hypertension, coronary heart disease and cerebral infarction in the elderly osteoporosis group is higher than that of the elderly population with normal bone density. In addition, studies have shown that the use of low bone density as a risk factor for cardiovascular and cerebrovascular events and death may predict the occurrence of cardiovascular and cerebrovascular diseases and the progress of the disease and is more accurate than traditional risk factors such as smoking and hyperlipidemia (11). Logistic regression analysis in this study showed that hypertension, coronary heart disease, and cerebral infarction were the main risk factors for osteoporosis in the elderly.…”

Section: Discussionmentioning

confidence: 99%

Relationship between senile osteoporosis and cardiovascular and cerebrovascular diseases

Yang

et al. 2019

Exp Ther Med

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The relationship between senile osteoporosis and cardiovascular hypertension, coronary heart disease and cerebral infarction was investigated. A retrospective study on 428 elderly patients hospitalized in Harrison International Peace Hospital from June 2014 to January 2017 was conducted. There were 207 cases of coronary heart disease, 102 cases of hypertension and 119 cases of cerebral infarction. According to bone density measurement results, the subjects were divided into the osteoporosis group and the non-osteoporosis group. Risk factors for osteoporosis were analyzed, and the incidence of osteoporosis in hypertension, coronary heart disease, and cerebral infarction populations of different severity was analyzed. Hypertension, coronary heart disease and cerebral infarction were the main risk factors for osteoporosis in the elderly. Incidence of osteoporosis in the double-vessel disease group and the three-vessel disease group was significantly higher than that in the single-vessel disease group. Incidence of osteoporosis was significantly higher in the three-vessel disease group than that in the double-vessel disease group (P<0.05). Incidence of osteoporosis was significantly higher in the moderate hypertension and severe hypertension groups than that in the mild hypertension group. Incidence of osteoporosis was significantly higher in patients with severe hypertension than that in the moderate hypertension group (P<0.05). Incidence of osteoporosis in patients with moderate cerebral infarction and severe cerebral infarction was significantly higher than that in the mild cerebral infarction group (P<0.05). Incidence of osteoporosis in patients with severe cerebral infarction was significantly higher than that in the moderate cerebral infarction group (P<0.05). The results indicated that there is a close correlation between senile osteoporosis and hypertension, coronary heart disease and cerebral infarction. Osteoporosis can be used as a predictor of early screening for hypertension, coronary heart disease and cerebral infarction in the elderly population.

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“…The trial population comprised of male or female patients of at least 50 years of age. In total, 50 patients with fractures of the vertebral body (TH7-L4) due to osteoporosis [14] or a trauma scheduled for one-staged kyphoplasty were consecutively screened and enrolled, and 49 were included in the safety population (SAF population). Exclusion criteria were known hypersensibility against ingredients of the tested bone cement, concomitant systemic gentamicin treatment, any concomitant disease (excluding a minimally invasive kyphoplasty of the vertebral body), presence of spondylitis or infection, renal impairment, sensorineural hearing loss, and hemorrhagic diathesis.…”

Section: Methodsmentioning

confidence: 99%

Properties and clinical application safety of antibiotic-loaded bone cement in kyphoplasty

Opalko¹,

Bösebeck

Vogt

2019

J Orthop Surg Res

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Background Evidence on antibiotic-loaded bone cement remains too vague to guide kyphoplasty in patient care. We clinically evaluated the properties and benefits of a new low viscosity polymethylmethacrylate (PMMA) bone cement loaded with gentamicin. Methods In this non-randomised, monocentric, prospective open trial, 50 consecutively enrolled patients with fractures of the vertebral body (TH7-L4) due to osteoporosis or trauma were investigated between 2010 and 2013, with a 1-year post-op follow-up per patient. The antibiotic-loaded PMMA bone cement was administered to patients during the surgery according to the standard procedure established on site for one-staged kyphoplasty. The clinical outcome was assessed according to function and pain by standardised anamnesis, clinical investigation, validated visual analogue scale (VAS) vertebral spine score, Oswestry Low-Back-Pain (ODI) Disability score, and Short Form (SF)-36 score. We further performed X-ray and magnetic resonance imaging with radiomorphometric assessment. Results The patients showed beneficial effects concerning low back pain disability (mean ODI score; screening, 68.0 ± 15.8% vs month 12, 42.8 ± 24.5%). The pain level was decreased (VAS vertebral spine score; screening, 68.8 ± 17.6 vs month 12, 43.8 ± 22.2) and the general health state was improved (SF-36; especially ‘role limitations due to emotional problems’ (51.9 ± 44.7; month 6), followed by ‘role limitations due to physical health’ (36.1 ± 42.4; month 6), and ‘pain’ (34.6 ± 35.3; month 6)). No vertebral infection did occur during the hospital stay or the 1-year follow-up. The stabilisation and restoration of the fractured bodies were radiologically confirmed. A reduced rate of leakage was observed, combined with a decreased risk of infection and an improved patient safety after a 1-year follow-up period. Conclusion Requirements for bone cement in a kyphoplasty setting were excellently fulfilled. Application technique and cement properties may influence the success of the surgery. Trial registration Deutsche Institut für Medizinische Dokumentation und Information (DIMDI), HM-KS-0901, Registered 14 September 2009, https://www.dimdi.de/dynamic/de/medizinprodukte/datenbankrecherche/

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Fracture History in Osteoporosis: Risk Factors and its Effect on Quality of Life

Abstract: Forearm, ankle and foot fractures can be commonly seen in osteoporosis patients with fracture history. We suggest that it is important to recognise osteoporosis prior to first fracture and disease-specific quality of life assessment should be done.

Cited by 20 publications

References 15 publications

Trends in osteoporosis and mean bone density among type 2 diabetes patients in the US from 2005 to 2014

Trends in osteoporosis and mean bone density among type 2 diabetes patients in the US from 2005 to 2014

Relationship between senile osteoporosis and cardiovascular and cerebrovascular diseases

Properties and clinical application safety of antibiotic-loaded bone cement in kyphoplasty

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