The present paper summarizes the results of fatigue crack growth investigations on a hollow railway axle which were performed as a joint research project between the Politecnico di Milano, Italy, and the GKSS Research Centre Geesthacht, Germany, in the frame of an ESIS-TC24 activity. Since no analytical K factors (SIF) solutions for semi-elliptical surface cracks in the S-transitions of railway axles were available, the first step in the research was to generate them for both reverse and rotary bending. The results were then used to investigate the effects of rotary bending and of the press fits at the wheel and gear on the fatigue crack growth and residual lifetime so as to provide essential input information for setting up inspection intervals. It was found that the effect of rotary bending, although existent, was rather moderate whereas the press fits had a large and detrimental effect.