Fracture non-union: Can biomarkers predict outcome?

Pountos, Ippokratis; Georgouli, T.; Pneumaticos, Spiros G.; Giannoudis, Peter V.

doi:10.1016/j.injury.2013.09.009

Cited by 77 publications

(61 citation statements)

References 93 publications

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“…A similar picture is described by authors who reviewed the role and potential of biochemical serum markers as indicators of fracture healing disturbances [33, 34, 36, 50, 51]. In theory, the above molecules could reflect a poor response to the regenerative treatment, but this cannot be ascertained in our study because of the lack of failed cases.…”

Section: Discussionsupporting

confidence: 69%

Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Granchi

Gómez‐Barrena

Rojewski

et al. 2017

Stem Cells International

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In this clinical trial, we investigated if biochemical bone turnover markers (BTM) changed according to the progression of bone healing induced by autologous expanded MSC combined with a biphasic calcium phosphate in patients with delayed union or nonunion of long bone fractures. Bone formation markers, bone resorption markers, and osteoclast regulatory proteins were measured by enzymatic immunoassay before surgery and after 6, 12, and 24 weeks. A satisfactory bone healing was obtained in 23 out of 24 patients. Nine subjects reached a good consolidation already at 12 weeks, and they were considered as the “early consolidation” group. We found that bone-specific alkaline phosphatase (BAP), C-terminal propeptide of type I procollagen (PICP), and beta crosslaps collagen (CTX) changed after the regenerative treatment, BAP and CTX correlated to the imaging results collected at 12 and 24 weeks, and BAP variation along the healing course differed in patients who had an “early consolidation.” A remarkable decrease in BAP and PICP was observed at all time points in a single patient who experienced a treatment failure, but the predictive value of BTM changes cannot be determined. Our findings suggest that BTM are promising tools for monitoring cell therapy efficacy in bone nonunions, but studies with larger patient numbers are required to confirm these preliminary results.

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Section: Discussionsupporting

confidence: 69%

Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Granchi

Gómez‐Barrena

Rojewski

et al. 2017

Stem Cells International

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“…This impaired fracture healing phenomenon has been attributed to a number of factors, including poor mechanical stability, extensive soft tissue and periosteal disruption, patient related co-morbidities, non-steroidal anti-inflammatory drugs, vitamin D deficiency and malnutrition amongst others [102,103]. Current research to understand better and to treat successfully fracture non-union is focusing on biological based approaches and involves the implantation of growth factors, osteoprogenitor cells, biophysical stimuli, and the promotion of local angiogenesis [104].…”

Section: Discussionmentioning

confidence: 99%

The role of pleiotrophin in bone repair

Lamprou

Kaspiris

Panagiotopoulos

et al. 2014

Injury

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“…Bone fracture is one of the top clinical challenges worldwide.On average, more than 20 billion dollars are spent to treat 7.9 million bone fracture patients in the United States every year (Dahabreh et al, ; Victoria et al, ; Antonova et al, ). The life quality of patients with delayed and non‐union healings is reduced due to a prolonged period of pain, disability, and repetitive operative interventions (Pountos et al, ). Laser capture microdissection (LCM) showed that the expression of DC‐STAMP was decreased in osteoclasts from diabetic mice whose bone healing is delayed (Kasahara et al, ).…”

Section: Possible Involvement Of Dc‐stamp In Biological Pathwaysmentioning

confidence: 99%

DC-STAMP: A Key Regulator in Osteoclast Differentiation

Chiu

Ritchlin

2016

J. Cell. Physiol.

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Osteoimmunology research is a new emerging research field that investigates the links between the bone and immune responses. Results from osteoimmunology studies suggest that bone is not only an essential component of the musculoskeletal system, but is also actively involved in immune regulation. Many important factors involved in immune regulation also participate in bone homeostasis. Bone homeostasis is achieved by a coordinated action between bone synthesizing osteoblasts and bone degrading osteoclasts. An imbalanced action between osteoblasts and osteoclasts often results in pathological bone diseases: osteoporosis is caused by an excessive osteoclast activity, whereas osteopetrosis results from an increased osteoblast activity. This review focuses on dendritic cell specific transmembrane protein (DC STAMP), an important protein currently considered as a master regulator of osteoclastogenesis. Of clinical relevance, the frequency of circulating DC STAMPþ cells is elevated during the pathogenesis of psoriatic diseases. Intriguingly, recent results suggest that DC STAMP also plays an imperative role in bone homeostasis by regulating the differentiation of both osteoclasts and osteoblasts. This article summarizes our current knowledge on DC STAMP by focusing on its interacting proteins, its regulation on osteoclastogenesis related genes, its possible involvement in immunoreceptor tyrosine based inhibitory motif (ITIM) mediated signaling cascade, and its potential of developing therapeutics for clinical applications.

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Fracture non-union: Can biomarkers predict outcome?

Cited by 77 publications

References 93 publications

Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

The role of pleiotrophin in bone repair

DC-STAMP: A Key Regulator in Osteoclast Differentiation

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