PurposeTo determine the fracture resistance of chairside computer‐aided design and computer‐aided manufacturing (CAD‐CAM) zirconia surveyed crowns for a mandibular first molar without occlusal rest and with four different rest seat designs.Materials and MethodsSeventy CAD‐CAM zirconia 4Y‐PSZ (IPS e.max ZirCAD MT for CEREC A1, C15, Ivoclar Vivadent) crowns (14 specimens/group) were designed and fabricated with a dental chairside CAD‐CAM system (CEREC PrimeScan, and CEREC MCXL Dentsply Sirona). The restorations were divided into groups according to the following rest seat designs: (1) Surveyed crown without rest seat, (2) surveyed crowns with disto‐occlusal rest seat, (3) surveyed crowns with disto‐occlusal extended rest seat, (4) surveyed crowns with interproximal rest seat, and (5) continuous rest seat. Crowns were treated with a primer system (Monobond Plus, Ivoclar Vivadent) and cemented using resin luting cement (Multilink Automix, Ivoclar Vivadent) to resin‐printed dies (Grey Resin V4, FormLabs). Subsequently, the crowns were subjected to 200,000 load cycles at 1 Hz with 20 N force and then loaded with a steel indenter until fracture. The test results were analyzed with one‐way Analysis of Variance (ANOVA) and HSD Tukey post‐Hoc test.ResultsThe mean fracture resistance of surveyed crowns without and with different rest seats was significantly different from each other. Surveyed crowns with no rest seat displayed the highest resistance (4238 N) followed by crowns with continuous rest seat (3601 N), crowns with disto‐occlusal extended rest seat (3283 N), and crowns with disto‐occlusal rest seat (3257 N). Crowns with interproximal rest seat displayed the lowest fracture resistance (2723 N).ConclusionsSurveyed crowns without rest seats had a higher fracture resistance than crowns with rest seats Surveyed crowns with interproximal rest seats presented the lowest fracture resistance among all rest seat designs. Crowns with disto‐occlusal rest seats, disto‐occlusal extended rest seats, and continuous rest seats displayed similar fracture resistance.