Fragile histidine triad protein: structure, function, and its association with tumorogenesis

Hassan, Md. Imtaiyaz; Naiyer, Abdullah; Ahmad, Faizan

doi:10.1007/s00432-009-0751-9

Cited by 31 publications

(18 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The deletion spans a large chromosome area and multiple genes. Of particular interest is the FHIT gene on 3p14.2 which is involved in loss of heterozygosity in a variety of human malignancies (Hassan et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…It has been estimated that $70% of breast carcinomas carry gross chromosomal abnormalities (Steinarsdottir et al, 1997;Teixeira et al, 2002). Any chromosome may be affected but most frequently reported are various rearrangements involving Chromosome 1, a deletion of the p-arm of Chromosome 3 including the putative tumor suppressor gene FHIT (Teixeira, 2009;Hassan et al, 2010), deletions from 6q and i(8)(q10) (Teixeira, 2009). Common numerical aberrations are gain of 7, 20, 18, and 8, and loss of X, 22, 13, and 17 (Teixeira, 2009).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytogenetic polyclonality of breast carcinomas: Association with Clinico‐Pathological Characteristics and Outcome

Steinarsdóttir

Gudmundsson

Jonasson

et al. 2011

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

Routinely used prognostic factors fail to predict clinical outcome in a significant proportion of breast cancer patients, implying that they can not detect some important biological characteristics. Chromosomal changes have been described in breast carcinomas for many years but their significance is not clear. We compared chromosomal changes with clinico-pathological characteristics and clinical outcome in 203 breast cancer patients with a follow-up of 9-18 years. Combining data from classical cytogenetics and flow cytometry revealed chromosomal abnormalities in 142 cases (70%). Of these, 51 (35.9%) contained two or more cytogenetically abnormal clones. Polyclonality was significantly associated with poor breast-cancer-specific survival (P = 0.03) within 5 years, independent of tumor size, lymph node metastases, and hormone receptors. Specific changes were similar to those previously described, but a new finding was a significant association between del 3p12p21 and poor survival. Polyclonality was significantly associated with TP53-mutations but not with a germline BRCA2 mutation. Less than one third of the polyclonal samples were identified by flow cytometry alone. Cytogenetic changes were detected in 17 out of 114 samples from non-tumorous tissue (15%), two of them identical with a clone in the corresponding tumor. Several samples contained clearly unrelated clones within the tumor and outside, implying either multifocal origin or early divergence. In conclusion, the common deletion on Chromosome 3p12p21 was associated with poor clinical outcome. Chromosomal polyclonality is common in breast carcinomas and predicts poor survival. Polyclonality was poorly detected by one-sample flow cytometry. Multiple sampling might improve the detection rate.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytogenetic polyclonality of breast carcinomas: Association with Clinico‐Pathological Characteristics and Outcome

Steinarsdóttir

Gudmundsson

Jonasson

et al. 2011

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

show abstract

“…Aberrant transcripts of the FHIT gene have been found in about one-half of all gastro-intestinal cancers (Hassan et al, 2010). As FHIT has functions inducing apoptosis, one could speculate that aberrant expression may have an influence on for instance, trophoblast invasion and therefore risk of miscarriage, but as far as we know, this has not been investigated.…”

Section: Genome-wide Linkage Studymentioning

confidence: 95%

A genome-wide scan in affected sibling pairs with idiopathic recurrent miscarriage suggests genetic linkage

Kolte

Nielsen

Moltke

et al. 2011

MHR: Basic Science of Reproductive Medicine

View full text Add to dashboard Cite

Previously, siblings of patients with idiopathic recurrent miscarriage (IRM) have been shown to have a higher risk of miscarriage. This study comprises two parts: (i) an epidemiological part, in which we introduce data on the frequency of miscarriage among 268 siblings of 244 patients with IRM and (ii) a genetic part presenting data from a genome-wide linkage study of 38 affected sibling pairs with IRM. All IRM patients (probands) had experienced three or more miscarriages and affected siblings two or more miscarriages. The sibling pairs were genotyped by the Affymetrix GeneChip 50K XbaI platform and non-parametric linkage analysis was performed via the software package Merlin. We find that siblings of IRM patients exhibit a higher frequency of miscarriage than population controls regardless of age at the time of pregnancy. We identify chromosomal regions with LOD scores between 2.5 and 3.0 in subgroups of affected sibling pairs. Maximum LOD scores were identified in four occurrences: for rs10514716 (3p14.2) when analyzing sister-pairs only; for rs10511668 (9p22.1) and rs341048 (11q13.4) when only analyzing families where the probands have had four or more miscarriages; and for rs10485275 (6q16.3) when analyzing one sibling pair from each family only. We identify no founder mutations. Concluding, our results imply that IRM patients and their siblings share factors which increase the risk of miscarriage. In this first genome-wide linkage study of affected sibling pairs with IRM, we identify regions on chromosomes 3, 6, 9 and 11 which warrant further investigation in order to elucidate their putative roles in the genesis of IRM.

show abstract

“…The fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, has been identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2 (Pichiorri et al, 2008;Hassan et al, 2010). Alterations of FHIT were found in several kinds of viral-associated tumors including hepatitis C virus (HCV)-associated hepatocellular carcinoma (Terry et al, 2004;Zekri et al, 2005;Wang et al, 2006;Deng et al, 2007).…”

Section: R E S E a R C H A R T I C L Ementioning

confidence: 99%

Persistent infections and their relationship with selected oncologic and non-tumor pathologies

Чумак

Abramenko

et al. 2010

Journal of Immunotoxicology

View full text Add to dashboard Cite

Fragile histidine triad protein: structure, function, and its association with tumorogenesis

Abstract: Here we have gathered information is known about biological activities of FHIT, the structural and biochemical bases for their functions. Our approach may provide a comparative framework for further investigation of FHIT.

Cited by 31 publications

References 133 publications

Cytogenetic polyclonality of breast carcinomas: Association with Clinico‐Pathological Characteristics and Outcome

Cytogenetic polyclonality of breast carcinomas: Association with Clinico‐Pathological Characteristics and Outcome

A genome-wide scan in affected sibling pairs with idiopathic recurrent miscarriage suggests genetic linkage

Persistent infections and their relationship with selected oncologic and non-tumor pathologies

Contact Info

Product

Resources

About