Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome

Frailty index: Intensive care unit complications in head and neck oncologic regional and free flap reconstruction

“…However, all procedures were combined into a heterogeneous surgical population from tonsillectomy to total thyroidectomy, without specifically including major operations. Frailty indices tend to best predict adverse outcomes in major operations . Our group has previously studied and validated that the modified frailty index score is a predictor of critical care complications in major head and neck oncologic surgery, but did not assess whether this applied to free or regional flap reconstructions after the ablation procedure.…”

Modified frailty index predicts postoperative outcomes in older gastrointestinal cancer patients

“…However, the time required for its implementation has limited its use in busy clinics . In contrast, mFI can be quickly calculated from information gathered from a standard history and physical examination, and has been found to be predictive of postoperative outcomes, including after major abdominal surgery . Specifically, Louwers et al reported that increased mFI was associated with a significant increase in Clavien Class 4 complications and mortality in patients undergoing hepatectomy, while Obeid et al found that increased mFI scores were associated with Clavien Class 4 and 5 complications in patients undergoing colectomy .…”

How should older adults with cancer be evaluated for frailty?

“…33 Among older patients with confirmed glioblastoma, an 11-item frailty index modeled after the accumulated deficits index predicted length of stay, post-operative surgical complications, and survival independent of Karnofsky performance status. 34 An index-type screening tool was successfully utilized to identify older trauma surgery patients who were at high risk for surgical complications and mortality. 35 In a study assessing predictors of post-operative complications among older adults (70+) requiring non-emergent solid tumor resection, the timed up and go test significantly predicted complications in addition to the American Society of Anesthesiologists score but the Groningen Frailty Index (GFI) and the Vulnerable Elders Survey (VES-13) did not.…”