Frailty is independently associated with 1-year mortality for elderly patients with non-ST-segment elevation myocardial infarction

Ekerstad, Niklas; Swahn, Eva; Janzon, Magnus; Alfredsson, Joakim; Löfmark, Rurik; Lindenberger, Marcus; Andersson, David; Carlsson, Per

doi:10.1177/2047487313490257

Cited by 84 publications

(93 citation statements)

References 36 publications

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“…Although we did measure comorbidities that are not typically collected in large cardiovascular studies (e.g., malignancies, psychiatric, and neurological disorders), it is highly possible that other nonmeasured parameters such as frailty status, postdischarge management, and lifestyle issues have much stronger influence on long-term mortality in older compared to younger patients with AMI [7,36].…”

Section: Discussionmentioning

confidence: 96%

Predictors of long-term (10-year) mortality postmyocardial infarction: Age-related differences. Soroka Acute Myocardial Infarction (SAMI) Project

Plakht

Shiyovich

Gilutz

2015

Journal of Cardiology

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Section: Discussionmentioning

confidence: 96%

Predictors of long-term (10-year) mortality postmyocardial infarction: Age-related differences. Soroka Acute Myocardial Infarction (SAMI) Project

Plakht

Shiyovich

Gilutz

2015

Journal of Cardiology

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“…Most studies on ACS based frailty assessment on retrospective review of medical files [12-14] instead of direct estimation of a frail phenotype. Sujino et al [15] conducted a prospective study in patients ≥85 years admitted with STEMI, exploring predictors of in-hospital mortality.…”

Section: Discussionmentioning

confidence: 99%

The Role of Frailty in Acute Coronary Syndromes in the Elderly

et al. 2018

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Background: Myocardial infarction (MI) patients are increasingly older, and common risk scores include chronological age, but do not consider chronic comorbidity or biological age. Frailty status reflects these variables and may be independently correlated with prognosis in this setting. Objective: This study investigated the impact of frailty on the prognosis of elderly patients admitted due to MI. Methods: This prospective and observational study included patients ≥75 years admitted to three tertiary hospitals in Spain due to MI. Frailty assessment was performed at admission using the Survey of Health, Ageing and Retirement in Europe Frailty Index (SHARE-FI) tool. The primary endpoint was the composite of death or non-fatal reinfarction during a follow-up of 1 year. Overall mortality, reinfarction, the composite of death, reinfarction and stroke, major bleeding, and readmission rates were also explored. Results: A total of 285 patients were enrolled. Frail patients (109, 38.2%) were older, with a higher score in the Charlson Comorbidity Index and with a higher risk score addressed in the GRACE and CRUSADE indexes. On multivariate analysis including GRACE, CRUSADE, maximum creatinine level, culprit lesion revascularization, complete revascularization, and dual antiplatelet therapy at discharge, frailty was an independent predictor of the composite of death and reinfarction (2.81, 95% CI 1.16–6.78) and overall mortality (3.07, 95% CI 1.35–6.98). Conclusion: Frailty is an independent prognostic marker of the composite of mortality and reinfarction and of overall mortality in patients aged ≥75 years admitted due to MI.

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“…[1][2][3] Skeletal muscle weakness is one of the phenotypes of frailty 4 and is strongly associated with reduced exercise capacity 5,6 and physical disability. 7 Recent studies have indicated that skeletal muscle strength is a prognostic factor in community-dwelling individuals, [8][9][10] chronic heart failure, 11,12 and in different patient populations.…”

Section: Introductionmentioning

confidence: 99%