Free amino acids: an innovative treatment for ocular surface disease

Rusciano, Dario; Roszkowska, Anna M.; Gagliano, Caterina; Pezzino, Salvatore

doi:10.1016/j.ejphar.2016.04.029

Cited by 23 publications

(22 citation statements)

References 99 publications

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“…Different from all the other amino acids, taurine has a sulfonic acid group instead of the classic carboxylic group. It is an important cytoprotective metabolite involved in anti-oxidative stress, anti-inflammation, osmoprotection, regeneration and regulation of Ca 2+ concentration (Ripps and Shen, 2012; Rusciano et al, 2016). In the rat, the amount of taurine level declines with age in the cornea and lens (Baskin et al, 1977; Yanshole et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Metabolic signature of the aging eye in mice

Wang

Grenell

Zhong

et al. 2018

Neurobiology of Aging

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Aging is a major risk factor for age-related ocular diseases including age-related macular degeneration in the retina and retinal pigment epithelium (RPE), cataracts in the lens, glaucoma in the optic nerve, and dry eye syndrome in the cornea. We used targeted metabolomics to analyze metabolites from young (6 weeks) and old (73 weeks) eyes in C57 BL6/J mice. Old mice had diminished electroretinogram responses and decreased number of photoreceptors in their retinas. Among the 297 detected metabolites, 45-114 metabolites are significantly altered in aged eye tissues, mostly in the neuronal tissues (retina and optic nerve) and less in cornea, RPE/choroid, and lens. We noted that changes of metabolites in mitochondrial metabolism and glucose metabolism are common features in the aged retina, RPE/choroid, and optic nerve. The aging retina, cornea, and optic nerve also share similar changes in Nicotinamide adenine dinucleotide (NAD), 1-methylnicotinamides, 3-methylhistidine, and other methylated metabolites. Metabolites in taurine metabolism are strikingly influenced by aging in the cornea and lens. In conclusion, the aging eye has both common and tissue-specific metabolic signatures. These changes may be attributed to dysregulated mitochondrial metabolism, reprogrammed glucose metabolism and impaired methylation in the aging eye. Our findings provide biochemical insights into the mechanisms of age-related ocular changes.

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Section: Discussionmentioning

confidence: 99%

Metabolic signature of the aging eye in mice

Wang

Grenell

Zhong

et al. 2018

Neurobiology of Aging

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“…Amino acids are the building blocks of proteins and are essential for the construction and the functioning of the entire organism [276,277]. Amino acids are naturally present in human tears and their imbalance or deficiency could contribute to the development of the pathologies affecting the ocular surface [278]. Two different studies have reported that the concentration of amino acids is different in human tears and in serum [279,280] and that tear concentration changes in patients affected by ocular dryness [280,281].…”

Section: Amino Acidsmentioning

confidence: 99%

Food Supplements in the Treatment of Ophthalmic Diseases: Preclinical and Clinical Studies

2020

J Pharmacol Pharm Res

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Among the 2.2 billion people in the world affected by any type of eye condition, the World Health Organization estimates 196 million with Age-related Macular Degeneration (AMD), 146 million with diabetic retinopathy (DR) and 76 million with glaucoma [1]. No clear estimate exists on the global presence of dry eye, though the English Agency known as Global-Data UK Ltd. in a document published on June 2018, considering the 8 more industrialised Countries (US,

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“…[5][6][7] Previous reports have pointed out that some amino acids can reduce inammation by inhibiting NF-kB activation, IL-6 production and expression of the leukocyte adhesion molecule CD62E. 8,9 Accordingly, exploring amino acids at a trace level in clinical samples prompted the need for a reliable, sensitive and convenient test method.…”

Section: Introductionmentioning

confidence: 99%

Analysis of amino acids in human tears by hydrophilic interaction liquid chromatography and quadrupole orbitrap mass spectrometry

2019

RSC Adv.

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Free amino acids: an innovative treatment for ocular surface disease

Cited by 23 publications

References 99 publications

Metabolic signature of the aging eye in mice

Metabolic signature of the aging eye in mice

Food Supplements in the Treatment of Ophthalmic Diseases: Preclinical and Clinical Studies

Analysis of amino acids in human tears by hydrophilic interaction liquid chromatography and quadrupole orbitrap mass spectrometry

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