Free and Conjugated Catecholamines in Human Plasma During Physical Exercise

Ratge, D.; Gehrke, A.; Melzner, Ingo; Wisser, H.

doi:10.1111/j.1440-1681.1986.tb00937.x

Cited by 41 publications

(22 citation statements)

References 21 publications

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“…The mechanism for the Variation of dopamine levels is unknown, mainly because the source of circulating dopamine has not yet been clearly established (27,28). While dopamine changes observed in controls during the cold test are in accord with those in previous studies (29), there is little information on measurement in the recovery phase following sympathetic Stimulation, although dopamine levels have been found to be unchanged after bicycle exercise and cross-country march (30). The different behaviour of dopamine vs norepinephrine and epinephrine 30 min after the cold test observed in our controls suggests that circulating dopamine has a role of its own and does not represent a mere reserve for circulating norepinephrine and epinephrine (27); in accord with this, we saw no correlation between the levels of dopamine and those of norepinephrine and epinephrine.…”

Section: Discussionsupporting

confidence: 77%

Cold-Induced Changes in Plasma Norepinephrine, Epinephrine and Dopamine Concentrations in Patients with Raynaud's Phenomenon

Marasini

Biondi

Mollica

et al. 1991

Clinical Chemistry and Laboratory Medicine

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Summary:To investigate the role of the sympathetic System in Raynaud's phenomenon, which has not yet been elucidated, we measured the levels of norepinephrine, epinephrine and dopamine before, immediately and 30 min after the cold pressor test in plasma from 17 patients with primary, 6 with secondary RaynautTs phenomenon and 19 volunteers, matched for age and sex. Patients had significantly low baseline epinephrine (0.13 ± 0.02 vs 0.37 ± 0.04, nmol/1, p < 0.001, mean ± S. E.), but normal norepinephrine and dopamine (norepinephrine: 1.77 ± 0.16 and 2.06 + 0.18; dopamine: 0.10 ± 0.01 and 0.11 + 0.02, patients and controls).Immediately after the cold test norepinephrine significantly increased (p < 0.001) in patients (2.42 + 0.22) and controls (3.24 ± 0.28); epinephrine increased in patients (0.18 ± 0.02, p < 0.02); dopamine did not show any significant change (0.13 ± 0.01 and 0.13 ± 0.02, patients and controls).In the recovery period, while norepinephrine and epinephrine returned to baseline in both groups, dopamine increased in controls (0.21 + 0.04, p < 0.005) but remained unchanged in patients (0.11 ± 0.01).We conclude that there is no sympathetic overactivity in Raynaud's phenomenon and propose a role for circulating dopamine in post-ischaemic vasodilatation äs an explanation for the particular behaviour of dopamine.

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Section: Discussionsupporting

confidence: 77%

Cold-Induced Changes in Plasma Norepinephrine, Epinephrine and Dopamine Concentrations in Patients with Raynaud's Phenomenon

Marasini

Biondi

Mollica

et al. 1991

Clinical Chemistry and Laboratory Medicine

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“…Doppler studies indicate an increase in uteroplacental vascular resistance with physical exertion (4). Both stress and strenuous physical exertion activate the sympathetic nervous system and therefore lead to the release of catecholamines and vasoconstriction, which, in turn, may have a detrimental effect on uteroplacental blood flow (50)(51)(52). Our findings that both physically demanding and stressful work conditions increase the risk of preeclampsia are in line with Hogue's hypothesis that hard physical work represents a set of acute physical stressors stimulating biophysical responses, which are similar to emotional stress (53).…”

Section: And Increased Peripheralmentioning

confidence: 99%

Population-based study on occupational risk factors for preeclampsia and gestational hypertension

Haelterman¹,

Marcoux²,

Croteau³

et al. 2007

Scand J Work Environ Health

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Haelterman E, Marcoux S, Croteau A, Dramaix M. Population-based study on occupational risk factors for preeclampsia and gestational hypertension. Scand J Work Environ Health 2007;33(4):304-317.Objectives Preeclampsia is a leading cause of maternal and perinatal morbidity. Work-related factors may influence the occurrence of this disorder. This case-control study estimated the associations between work-related physical and psychosocial factors and the risk of preeclampsia and gestational hypertension. MethodsThe eligible women consisted of a random sample of the women who delivered a singleton live birth in 1997-1999 in six regions of Quebec and worked during pregnancy. Cases of preeclampsia (N=102) and gestational hypertension (N=99) were compared with normotensive controls (N=4381). Information on occupational exposures at the onset of pregnancy was collected during phone interviews a few weeks after delivery. Detailed information was obtained on work schedule, postures, physical exertion, work organization, noise, vibration, and extreme temperature. Adjusted odds ratios (aOR) were estimated through polytomous logistic regression. ResultsWomen standing daily at least 1 hour consecutively without walking experienced a higher risk of preeclampsia [aOR 2.5, 95% confidence interval (95% CI) 1.4-4.6], as well as women climbing stairs frequently (aOR 2.3, 95% CI 1.2-4.1) and women working more than 5 consecutive days without a day-off (aOR 3.0, 95% CI 1.0-9.5). Squatting or kneeling, pushing or pulling objects, whole-body vibration, forced pace, job strain, and no control on breaks were positively, but nonsignificantly, associated with preeclampsia. The associations were weaker for gestational hypertension.Conclusions These findings suggest that being exposed to physically demanding and stressful occupational conditions at the onset of pregnancy increases the risk of preeclampsia.

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“…It has been hypothesized that measurement of plasma concentrations of noradrenaline sulphate (NA-S) after exercise is an appropriate estimate of the overall activity of the sympathetic nervous system (Ratge et al 1986;Sagnol et al 1990). This hypothesis has been based on ®ndings that NA-S in the plasma is biologically synthesized from free NA (Renskers et al 1980), that plasma concentration of NA-S increases with exercise (Cleroux et al 1983;Ratge et al 1986;Sothmann et al 1987;Sagnol et al 1990;Strobel et al 1994), and that plasma NA-S remains elevated over prolonged periods after exercise (Ratge et al 1986;Sagnol et al 1990;Strobel et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Effect of repeated bouts of short-term exercise on plasma free and sulphoconjugated catecholamines in humans

Strobel¹,

Reiss²,

Friedmann³

et al. 1998

European Journal of Applied Physiology

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We tested the hypothesis that measurement of plasma catecholamine sulphate concentration after exercise reflects the overall activation of the sympathoadrenergic system during the whole period of repeated bouts of short-term exercise. A group of 11 male athletes performed two exercise tests at similar average power outputs consisting of three sets each. The tests either started with one set of three very intense sprints (95% of maximal running speed) followed by two sets of three less intense sprints (85% of maximal running speed; HLX) or vice versa (LHX). Similar mean areas under the curve of free noradrenaline (NA) during HLX and LHX [622 (SEM 13) v.s. 611 (SEM 14) nmol x l(-1) min) as well as similar mean heart rates [143 (SEM 9) v.s. 143 (SEM 8) beats x min(-1)] indicated comparable sympathetic activation during both exercise tests. Even so, plasma concentration of free NA was still significantly higher at the end of LHX than of HLX [35.7 (SEM 3.5) v.s. 22.5 (SEM 2.1) nmol x l(-1), respectively], i.e. when exercise ended with the more intense set of sprints. Plasma noradrenaline sulphate (NA-S) increased with exercise intensity showing higher mean increments after the first set of HLX compared to LHX [1.83 (SEM 0.42) v.s. 1.18 (SEM 0.29) nmol x l(-1); P<0.05]. However, after the end of HLX and LHX, increments in plasma NA-S were similar [4.52 (SEM 0.76) v.s. 4.06 (SEM 0.79) nmol x l(-1)], suggesting that NA-S response changed in parallel with the overall activation of the sympathetic nervous system during repeated bouts of short-term exercise. The results supported the hypothesis that measurement of plasma NA-S immediately after repeated bouts of short-term exercise reflects overall activation of the sympathetic nervous system during prolonged periods of this type of exercise.

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Free and Conjugated Catecholamines in Human Plasma During Physical Exercise

Cited by 41 publications

References 21 publications

Cold-Induced Changes in Plasma Norepinephrine, Epinephrine and Dopamine Concentrations in Patients with Raynaud's Phenomenon

Cold-Induced Changes in Plasma Norepinephrine, Epinephrine and Dopamine Concentrations in Patients with Raynaud's Phenomenon

Population-based study on occupational risk factors for preeclampsia and gestational hypertension

Effect of repeated bouts of short-term exercise on plasma free and sulphoconjugated catecholamines in humans

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