Cold-Induced Changes in Plasma Norepinephrine, Epinephrine and Dopamine Concentrations in Patients with Raynaud's Phenomenon

Marasini, Bianca; Biondi, Maria Luisa; Mollica, R.; Santo, Antonio; Agostoni, A

doi:10.1515/cclm.1991.29.2.111

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…In our study, among the 15 patients with Raynaud's syndrome, only one was Val/Val, the other 14 was carrying at least one Met allele. Changes in circulating dopamine, which might be affected by COMT Val158Met polymorphism, were observed in a study about Raynaud's disease (Marasini et al, 1991). These results might indicate that dopamine plays a role in Raynaud's phenomenon.…”

Section: Discussionmentioning

confidence: 71%

Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism

Inanir

Karakuş²,

Ateş³

et al. 2014

Xenobiotica

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1. Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. The aim of this study was to explore the frequency and clinical significance of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in a large cohort of Turkish patients with FMS. 2. The study included 379 FMS patients and 290 controls. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses. 3. The genotype frequencies of Val158Met polymorphism showed a small difference between FMS patients and healthy controls (p = 0.047), however, the Met/Met genotype was significantly higher in FMS patients than healthy controls (p = 0.016). No difference was observed for allele frequencies between two groups. Stratification analysis according to clinical features for this disease reveals that weight, FMS Impact Questionnaire score, algometry and Raynaud's syndrome, were detected to have statistically significant associations with Val158Met polymorphism (p = 0.037, p = 0.042, p = 0.039 and p = 0.033, respectively). Pain sensitivity, measured by algometry, was statistically higher in patients with Met/Met genotype than the patients with Val/Val and Val/Met genotypes (p = 0.017). 4. The results of this study suggested that COMT gene Val158Met polymorphism is positively associated with FMS and play a relevant role in the clinical symptoms of the disease.

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Section: Discussionmentioning

confidence: 71%

Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism

Inanir

Karakuş²,

Ateş³

et al. 2014

Xenobiotica

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“…This theory is consistent with RP being the result of an intrinsic problem within the blood vessels and not a result of a systemic or humoral problem. 36 For example, levels of neither epinephrine nor norepinephrine are elevated in RP sufferers, 37 , 38 and it is possible to induce an RP episode in a digit that has its sympathetic nerve output blocked; 26 , 39 facts that both allude to vascular disorder.…”

Section: Discussionmentioning

confidence: 99%

Raynaud phenomenon and mortality: 20+ years of follow-up of the Charleston Heart Study cohort

Nietert¹,

Shaftman²,

Silver³

et al. 2015

CLEP

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BackgroundRaynaud phenomenon (RP) is a temporary vasoconstrictive condition that often manifests itself in the fingers in response to cold or stress. It often co-occurs with certain chronic diseases that impact mortality. Our objective was to determine whether RP has any independent association with survival.MethodsFrom 1987–1989, a total of 830 participants of the Charleston Heart Study cohort completed an in-person RP screening questionnaire. Two definitions of RP were used: a broad definition that included both blanching (pallor) and cyanotic color changes and a narrow definition that included only blanching. All-cause and cardiovascular disease (CVD) mortality were compared between subjects with and without RP using race-specific survival models that adjusted for age, sex, baseline CVD, and 10-year risk of coronary heart disease.ResultsUsing the narrow RP definition, we identified a significant interaction between older age and the presence of RP on all-cause mortality. In the broad RP definition model, the presence of RP was not associated with CVD mortality among blacks; however, among whites, the presence of RP was associated with a 1.6-fold increase in the hazard associated with CVD-related death (hazard ratio: 1.55, 95% confidence interval: 1.10–2.20, P=0.013).ConclusionRP was independently associated with mortality among older adults in our cohort. Among whites, RP was associated with increased CVD-related death. It is possible that RP may be a sign of undiagnosed vascular disease.

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“…Future studies with atomoxetine should thus be performed in a larger number of subjects. Preliminary results in humans indicate that atomoxetine, as well as sympathetic activation by ketamine and the cold pressor test ( Marasini et al, 1991 ) reduce [ 11 C]ORM-13070 binding by 10–15% in human subjects ( Lehto et al, 2014 ; Scheinin et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Amphetamine Decreases 2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain

Finnema

Hughes

Haaparanta‐Solin

et al. 2014

International Journal of Neuropsychopharmacology

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Background:The neurotransmitter norepinephrine has been implicated in psychiatric and neurodegenerative disorders. Examination of synaptic norepinephrine concentrations in the living brain may be possible with positron emission tomography (PET), but has been hampered by the lack of suitable radioligands.Methods:We explored the use of the novel α2C-adrenoceptor antagonist PET tracer [11C]ORM-13070 for measurement of amphetamine-induced changes in synaptic norepinephrine. The effect of amphetamine on [11C]ORM-13070 binding was evaluated ex vivo in rat brain sections and in vivo with PET imaging in monkeys.Results:Microdialysis experiments confirmed amphetamine-induced elevations in rat striatal norepinephrine and dopamine concentrations. Regional [11C]ORM-13070 receptor binding was high in the striatum and low in the cerebellum. After injection of [11C]ORM-13070 in rats, mean striatal specific binding ratios, determined using cerebellum as a reference region, were 1.4±0.3 after vehicle pretreatment and 1.2±0.2 after amphetamine administration (0.3mg/kg, subcutaneous). Injection of [11C]ORM-13070 in non-human primates resulted in mean striatal binding potential (BP ND) estimates of 0.65±0.12 at baseline. Intravenous administration of amphetamine (0.5 and 1.0mg/kg, i.v.) reduced BP ND values by 31–50%. Amphetamine (0.3mg/kg, subcutaneous) increased extracellular norepinephrine (by 400%) and dopamine (by 270%) in rat striata.Conclusions:Together, these results indicate that [11C]ORM-13070 may be a useful tool for evaluation of synaptic norepinephrine concentrations in vivo. Future studies are required to further understand a potential contribution of dopamine to the amphetamine-induced effect.

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Cold-Induced Changes in Plasma Norepinephrine, Epinephrine and Dopamine Concentrations in Patients with Raynaud's Phenomenon

Cited by 7 publications

References 25 publications

Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism

Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism

Raynaud phenomenon and mortality: 20+ years of follow-up of the Charleston Heart Study cohort

Amphetamine Decreases 2C-Adrenoceptor Binding of [11C]ORM-13070: A PET Study in the Primate Brain

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