Free and hydrogel encapsulated exosome-based therapies in regenerative medicine

Akbari, Ali; Jabbari, Nassrollah; Sharifi, Roholah; Ahmadi, Mahdi; Vahhabi, Ali; Seyedzadeh, Seyyed Javad; Nawaz, Muhammad; Szafert, Sławomir; Mahmoodi, Monireh; Jabbari, Esmaiel; Asghari, Rahim; Rezaie, Jafar

doi:10.1016/j.lfs.2020.117447

Cited by 131 publications

(112 citation statements)

References 124 publications

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“…Also, they can be classified as non-immunogenic due to a limited amount of antigenic components [64]. In recent years, various approaches have been used to deliver exosomes to target tissues in different disease models, and also, there have been some clinical trials [65]. Exosomes include more than 150 miRNA [66] and 850 proteins [67], which play roles in both pathological and physiological events.…”

Section: Exosomesmentioning

confidence: 99%

“…Those derived from MSCs consist of different cytokines and growth factors, such as IL-6, IL-10, TGFβ1, and HGF, which comply with the regulation of immune responses [68]. MSCs-Ex has therapeutic effects in different conditions, including cardiovascular diseases, neurological diseases, kidney diseases, and wound healing [65]. MSC-EVs-based therapy could inhibit influenza virus replication and virus-induced apoptosis in lung epithelial cells [69].…”

Section: Exosomesmentioning

confidence: 99%

See 1 more Smart Citation

Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises

Basiri

Pazhouhnia

Beheshtizadeh

et al. 2020

Stem Cell Rev and Rep

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Novel coronavirus disease (COVID-19) has attracted much attention around the world due to its rapid transmission among humans and relatively high mortality rate. Studies are increasing to find the best therapeutic approach for the disease and its management. Regenerative medicine offers various cell-tissue therapeutics and related products, such as stem cell therapy, natural killer (NK) cell therapy, Chimeric antigen receptor (CAR) T cell therapy, exosomes, and tissue products. Interestingly, mesenchymal stem cells (MSCs) can reduce inflammatory symptoms and protect against cytokine storm, which critically contributes to the COVID-19 progression. Notably, having the potentials to exert cytotoxic effects on infected cells and induce interferon production probably make NK cells a candidate for COVID-19 cell therapy. Besides, exosomes are one of the crucial products of cells that can exert therapeutic effects through the induction of immune responses and neutralizing antibody titers. The paper aims to briefly consider current options for COVID-19 therapy to show that there is no specific cure for COVID-19, and then assess the real opportunities and range of promises regenerative medicine can provide for specific treatment of COVID-19.

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Section: Exosomesmentioning

confidence: 99%

Section: Exosomesmentioning

confidence: 99%

Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises

Basiri

Pazhouhnia

Beheshtizadeh

et al. 2020

Stem Cell Rev and Rep

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show abstract

“…Mesenchymal stem/stromal cells (MSCs) are multipotent nonhematopoietic adult cells initially discovered by Alexander Friedenstein while studying the bone marrow. MSCs, possibly originated from the mesoderm, were reported to express CD73, CD90 and CD105 plasma membrane markers while not expressing CD14, CD34 and CD45 molecules [1,2]. In addition to the bone marrow, MSCs can be isolated from other adult tissues including adipose tissue, amniotic fluid, dental pulp, placenta, umbilical cord blood, Wharton's jelly and even the brain, kidney, liver, lung, spleen, pancreas and thymus [1,3].…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

et al. 2020

Self Cite

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Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for over a few decades by virtue of their differentiation capacity, potent immunomodulatory properties, and their ability to be favorably cultured and manipulated. Recent investigations implied that the pleiotropic effects of MSCs is not associated to their ability of differentiation, but rather is mediated by the secretion of soluble paracrine factors. Exosomes, nanoscale extracellular vesicles, are one of these paracrine mediators. Exosomes transfer functional cargos like miRNA and mRNA molecules, peptides, proteins, cytokines and lipids from MSCs to the recipient cells. Exosomes participate in intercellular communication events and contribute to the healing of injured or diseased tissues and organs. Studies reported that exosomes alone are responsible for the therapeutic effects of MSCs in numerous experimental models. Therefore, MSC-derived exosomes can be manipulated and applied to establish a novel cell-free therapeutic approach for treatment of a variety of diseases including heart, kidney, liver, immune and neurological diseases, and cutaneous wound healing. In comparison with their donor cells, MSC-derived exosomes offer more stable entities and diminished safety risks regarding the administration of live cells, e.g. microvasculature occlusion risk. This review discusses the exosome isolation methods invented and utilized in the clinical setting thus far and presents a summary of current information on MSC exosomes in translational medicine.

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“…These molecules perform different biological functions ( Figure 2 ). 13 , 49 The outer membrane of exosomes are basically composed of lipids, interspersed with a variety of membrane proteins. Specific lipids that are abundant in exosomes (eg, cholesterol, phospholipids, and phosphatidylserine) have been investigated.…”

Section: Characteristics and Biogenesis Of Exosomesmentioning

confidence: 99%

“… 11 , 12 A MVB is an intermediate endosomal compartment that is filled with ILVs. 13 Diverse bioactive molecules including lipids, proteins, and nucleic acids are the main functional components of exosomes, which are encapsulated in a lipid bilayer membrane. 14 , 15 Exosomes are a promising field of cytological and biomedical research, attracting intense interest because of the biological functions and broad contribution of exosomes to a range of diseases.…”

Section: Introductionmentioning

confidence: 99%

Roles of Exosomes in Ocular Diseases

Liu

Jiang

et al. 2020

IJN

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Exosomes, nanoscale vesicles with a diameter of 30 to 150 nm, are composed of a lipid bilayer, protein, and genetic material. Exosomes are secreted by virtually all types of cells in the human body. They have key functions in cell-to-cell communication, immune regulation, inflammatory response, and neovascularization. Mounting evidence indicates that exosomes play an important role in various diseases, such as cancer, cardiovascular diseases, and brain diseases; however, the role that exosomes play in eye diseases has not yet been rigorously studied. This review covers current exosome research as it relates to ocular diseases including diabetic retinopathy, age-related macular degeneration, autoimmune uveitis, glaucoma, traumatic optic neuropathies, corneal diseases, retinopathy of prematurity, and uveal melanoma. In addition, we discuss recent advances in the biological functions of exosomes, focusing on the toxicity of exosomes and the use of exosomes as biomarkers and drug delivery vesicles. Finally, we summarize the primary considerations and challenges to be taken into account for the effective applications of exosomes.

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Free and hydrogel encapsulated exosome-based therapies in regenerative medicine

Cited by 131 publications

References 124 publications

Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises

Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

Roles of Exosomes in Ocular Diseases

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