Free D-Aspartate in Mammals

Furuchi, Takemitsu; Homma, Hiroshi

doi:10.1248/bpb.28.1566

Cited by 84 publications

(39 citation statements)

References 54 publications

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“…However, D-amino acids were recently detected in various living higher organisms in the form of free amino acids, peptides, and proteins. Free D-Asp may be related to differentiation and development in living organisms (23), and D-serine plays a role as a coagonist of NMDA receptors in the brain (24). Some D-amino acid-containing peptides were found in opioid peptides (25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

A Rapid, Comprehensive Liquid Chromatography-Mass Spectrometry (LC-MS)-based Survey of the Asp Isomers in Crystallins from Human Cataract Lenses

Fujii

Sakaue

Sekiya

et al. 2012

Journal of Biological Chemistry

110

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Background: Asp isomers in lens crystallins are one of the triggers of cataracts. Results: Multiple highly isomeric Asp sites in insoluble crystallins from cataract lenses were identified by LC-MS using the corresponding synthetic peptides as standards. Conclusion: Asp isomers induce insolubilization of crystallin, leading to cataracts. Significance: This study opens up a new field of protein biochemistry in age-related diseases.

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Section: Discussionmentioning

confidence: 99%

A Rapid, Comprehensive Liquid Chromatography-Mass Spectrometry (LC-MS)-based Survey of the Asp Isomers in Crystallins from Human Cataract Lenses

Fujii

Sakaue

Sekiya

et al. 2012

Journal of Biological Chemistry

110

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“…D-Ser is thought to be a neuromodulator of the N-methyl-D-aspartate (NMDA) subtype of the glutamate (Glu) receptors in the brain, [3][4][5] and DAsp is reported to regulate hormonal secretion in various endocrine glands. [6][7][8][9] While the amounts of other D-amino acids in mammals are low, and they have not been well investigated due to the lack of appropriate analytical methods.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Two-Dimensional Determination of Small Amounts of D-Amino Acids in Mammals and the Study on Their Functions

Hamase

2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…D-Asp is widespread in marine invertebrates (Zagon et al 1994) and is an endogenous amino acid present in nervous and endocrine tissues in mammals (Furuchi and Homma 2005). It is the precursor for the important neurotransmitter agonist, NMDA.…”

Section: D-aspartic Acidmentioning

confidence: 99%

“…Additionally, DDO activity has been found in the kidney, liver, and brain of mammals (Katane and Homma 2010). The ability of mammalian cells to regulate D-Asp implies that D-Asp is a novel type of messenger in the mammalian body (Furuchi and Homma 2005).…”

Section: D-aspartic Acidmentioning

confidence: 99%

Nutritional and medicinal aspects of d-amino acids

2011

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This paper reviews and interprets a method for determining the nutritional value of D-amino acids, D-peptides, and amino acid derivatives using a growth assay in mice fed a synthetic all-amino acid diet. A large number of experiments were carried out in which a molar equivalent of the test compound replaced a nutritionally essential amino acid such as L-lysine (L-Lys), L-methionine (L-Met), L-phenylalanine (L-Phe), and L-tryptophan (L-Trp) as well as the semi-essential amino acids L-cysteine (L-Cys) and L-tyrosine (L-Tyr). The results show wide-ranging variations in the biological utilization of test substances. The method is generally applicable to the determination of the biological utilization and safety of any amino acid derivative as a potential nutritional source of the corresponding L-amino acid. Because the organism is forced to use the D-amino acid or amino acid derivative as the sole source of the essential or semi-essential amino acid being replaced, and because a free amino acid diet allows better control of composition, the use of all-amino-acid diets for such determinations may be preferable to protein-based diets. Also covered are brief summaries of the widely scattered literature on dietary and pharmacological aspects of 27 individual D-amino acids, D-peptides, and isomeric amino acid derivatives and suggested research needs in each of these areas. The described results provide a valuable record and resource for further progress on the multifaceted aspects of D-amino acids in food and biological samples.

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Free D-Aspartate in Mammals

Cited by 84 publications

References 54 publications

A Rapid, Comprehensive Liquid Chromatography-Mass Spectrometry (LC-MS)-based Survey of the Asp Isomers in Crystallins from Human Cataract Lenses

A Rapid, Comprehensive Liquid Chromatography-Mass Spectrometry (LC-MS)-based Survey of the Asp Isomers in Crystallins from Human Cataract Lenses

Sensitive Two-Dimensional Determination of Small Amounts of D-Amino Acids in Mammals and the Study on Their Functions

Nutritional and medicinal aspects of d-amino acids

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