Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells

Yadav, Ajay; Sata, Teja Naveen; Verma, Daksh; Mishra, Amit; Sah, Amrendra Kumar; Hossain, Md. Musa; Pant, Kishor; Venugopal, Senthil K.

doi:10.1016/j.lfs.2022.120625

Cited by 5 publications

(6 citation statements)

References 47 publications

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“…6 The apoptotic signaling pathways include the proapoptotic protein Bax and the antiapoptotic protein Bcl-2. 7 Bcl-2 can inhibit cell apoptosis mainly by blocking the signaling pathway of apoptosis, while the expression of Bax can promote cell apoptosis. 8 In the Bcl-2 gene family, the apoptosis-promoting gene Bax has been researched extensively due to its high degree of similarity with Bcl-2.…”

Section: Discussionmentioning

confidence: 99%

“…Apoptotic processes are regulated by antiapoptotic (Bcl‐2) family proteins and Caspase family proteins by regulating the transduction of apoptotic signals, and their mutual checks and balances form a complete and efficient apoptosis mechanism network system 6 . The apoptotic signaling pathways include the proapoptotic protein Bax and the antiapoptotic protein Bcl‐2 7 . Bcl‐2 can inhibit cell apoptosis mainly by blocking the signaling pathway of apoptosis, while the expression of Bax can promote cell apoptosis 8…”

Section: Discussionmentioning

confidence: 99%

“… 6 The apoptotic signaling pathways include the proapoptotic protein Bax and the antiapoptotic protein Bcl‐2. 7 Bcl‐2 can inhibit cell apoptosis mainly by blocking the signaling pathway of apoptosis, while the expression of Bax can promote cell apoptosis. 8 …”

Section: Discussionmentioning

confidence: 99%

“…(1) Patients with other anal diseases, such as anal fissure, perianal abscess, perianal eczema, rectal polyps, anal papilloma; (2) Patients suffering from chronic diarrhea or other gastrointestinal infections; (3) Patients diagnosed with malignant tumors in the body; (4) Patients with diseases affecting vital organs such as heart, brain, liver, lung, kidney, or diagnosed with psychiatric illnesses; (5) Pregnant and lactating women; (6) Patients allergic to Zibai ointment; (7) Patients who underwent anesthesia and surgical procedures that were different from those for inclusion in this study, or with incomplete data that impacted the efficacy assessment.…”

Section: Exclusion Criteriamentioning

confidence: 99%

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Investigating the role of Zibai ointment on apoptosis‐related factors Bcl‐2 and Bax in wound healing after anal fistula surgery

Cai

Cheng

Wang

et al. 2023

Immunity Inflam & Disease

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In this study, we investigated the impact of Zibai ointment on wound healing by analyzing the expression levels of two key apoptosis-related factors-B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), in patients following surgery for anal fistula. Methods:We included 90 patients with anal fistulas who were treated in the People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine. Patients were randomly assigned to receive treatment with Zibai ointment (n = 45) or petroleum jelly (n = 45). The levels of apoptosis-related factors Bcl-2 and Bax were evaluated using enzyme-linked immunosorbent assay (ELISA), while cell apoptosis was assessed using Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay. Results:The results of ELISA showed that on Day 21 after the surgery, the levels of Bcl-2 and Bax in the Zibai ointment group were significantly different compared to the petroleum jelly group, with values of (60.11 ± 1.31) ng/mL and (7.05 ± 0.01) versus (83.79 ± 1.74) ng/mL and (6.00 ± 0.05) ng/mL, respectively (p < .05). Furthermore, light microscopy revealed a large number of apoptotic cells within the field of vision 14 days postsurgery in the Zibai ointment group, and the healing time in the Zibai ointment group was significantly different from that in the petroleum jelly group (p < .05). Conclusion: We found that Zibai ointment effectively promoted wound healing in patients following anal fistula surgery, possibly by regulating Bcl-2 and Bax apoptosis-related factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Exclusion Criteriamentioning

confidence: 99%

See 2 more Smart Citations

Investigating the role of Zibai ointment on apoptosis‐related factors Bcl‐2 and Bax in wound healing after anal fistula surgery

Cai

Cheng

Wang

et al. 2023

Immunity Inflam & Disease

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show abstract

“…Increasing evidence indicates that miR-NAs regulate several biological processes (8). MicroR-NA-181a-5p was found to play a significant role in liver damage or non-alcoholic fatty liver disease (9,10). However, the regulatory mechanism of microRNA-181a-5p in ALF remains to be elucidated, and whether there is a link between microRNA-181a-5p and hepatocyte apoptosis is unclear.…”

Section: Introductionmentioning

confidence: 99%