Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study

Zhu, Bin; Zhang, Junrong; Zheng, Qingzhu; Dong, Bin; Wang, Meihua; Liu, Jin; Cao, Yingping

doi:10.2147/cmar.s307753

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Previous results conducted by our research group in a large European population revealed that circulating bacterial DNA load was associated with fatty acid (FFA) levels and leukocyte count, [ 22 ] which represent common biomarkers with diagnostic or prognostic value in CRC [ 23 , 24 , 25 ]. Since the presence of the circulating microbiome in blood has been reported under both physiological and pathological conditions, the detection of altered circulating bacterial DNA could serve as a promising non-invasive biomarker for cancer detection tools.…”

Section: Introductionmentioning

confidence: 99%

Plasma Bacterial DNA Load as a Potential Biomarker for the Early Detection of Colorectal Cancer: A Case–Control Study

Giacconi,

Donghia,

Arborea

et al. 2023

Microorganisms

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The gut microbiota has gained increasing attention in recent years due to its significant impact on colorectal cancer (CRC) development and progression. The recent detection of bacterial DNA load in plasma holds promise as a potential non-invasive approach for early cancer detection. The aim of this study was to examine the quantity of bacterial DNA present in the plasma of 50 patients who have CRC in comparison to 40 neoplastic disease-free patients, as well as to determine if there is a correlation between the amount of plasma bacterial DNA and various clinical parameters. Plasma bacterial DNA levels were found to be elevated in the CRC group compared to the control group. As it emerged from the logistic analysis (adjusted for age and gender), these levels were strongly associated with the risk of CRC (OR = 1.02, p < 0.001, 95% C.I.: 1.01–1.03). Moreover, an association was identified between a reduction in tumor mass and the highest tertile of plasma bacterial DNA. Our findings indicate that individuals with CRC displayed a higher plasma bacterial DNA load compared to healthy controls. This observation lends support to the theory of heightened bacterial migration from the gastrointestinal tract to the bloodstream in CRC. Furthermore, our results establish a link between this phenomenon and the size of the tumor mass.

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Section: Introductionmentioning

confidence: 99%

Plasma Bacterial DNA Load as a Potential Biomarker for the Early Detection of Colorectal Cancer: A Case–Control Study

Giacconi,

Donghia,

Arborea

et al. 2023

Microorganisms

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“…[7][8][9][10] An epidemiological study showed that free fatty acids (FFA) levels can complement the predictive ability of CEA and CA19-9 and differentiate them from TNM staging. 11 These are associated with cancer by numerous metabolic pathways 4 and often by the growth and proliferation of FFA and HDL-C that meet energy requirements. 5 More particularly, high cholesterol demand is essential for tumor proliferation and OS in different types of endocrine cancers, including HCC.…”

Section: Introductionmentioning

confidence: 99%

Lipid-Based Factors: A Promising New Biomarker for Predicting Prognosis and Conditional Survival Probability in Hepatocellular Carcinoma

Guo

Liang

2022

JHC

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Purpose Abnormalities in lipid metabolism play a vital role in the development of cancer. This retrospective study aimed to evaluate the survival prognosis of patients with hepatocellular carcinoma (HCC) in terms of (free fatty acid: high-density lipoproteins) ratio (FF-HL) and to compare it with conditional probability and annual death hazard. Patients and Methods Patients (n=300) were enrolled. Time-dependent receiver operating characteristic (ROC) analysis was used to determine the predictive ability of survival. Survival probabilities were estimated using the Kaplan–Meier method and Log rank tests were performed for statistical significance. Results The area under the ROC curve for FF-HL, which predicts overall survival (OS), was superior to other markers. Patients in the high FF-HL (>840.3) showed poorer OS and progress-free survival (PFS). In multivariable analysis, FF-HL was an independent marker in predicting OS. Younger people and those with intrahepatic metastasis in higher FF-HL groups, as well as older men without vascular invasion in higher AHLR groups showed shorter OS and PFS. 3-year conditional disease-free survival (CDFS 3 ) was slightly higher than those with actuarial survival. The death risk for 3-year conditional OS (COS 3 ) was stable in the group with low FF-HL and (albumin: high-density lipoproteins) ratio (AHLR) and more pronounced in high subgroups. However, risk stratification using the Barcelona Clinic Liver Cancer approach and Child-Pugh score might not accurately predict COS 3 . Conclusion FF-HL and AHLR are not only promising biomarkers in terms of predictive ability of OS and PFS but also provide time-dependent prognostic information for HCC patients.

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“…Free fatty acids (FFAs) are triacylglycerol (TG) precursors that are needed to replenish TG stores in adipose, liver and muscle tissue through esteri cation; when hepatic glycogen is low and muscles need energy, the TGs in adipose tissue are broken down into FFAs for energy (Stich and Berlan 2004). FFAs are overexpressed in colorectal patients (Zhu et al 2021), and abnormal fatty acid metabolismis associated with tumour cell metastasis in various cancers, including colorectal cancer (Kawaguchi et al 2016;Zhang et al 2020). High-density lipoprotein (HDL) is responsible for the reverse transport of cholesterol from peripheral cells to the liver, and associated apolipoproteins and enzymes can also exert antioxidant, antiin ammatory, antiangiogenic, antiapoptotic and immunomodulatory activities, resulting in overall antitumorigenic effects (Ganjali et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Combined Detection of Free Fatty Acid (FFA) and High-Density Lipoprotein Cholesterol (HDL-C) is a Promising Pretreatment Biomarker for Predicting the Overall Prognosis (OS) of Neuroendocrine Tumours (NETs) in the Colorectum: A Case-Control Study.

Zhu

Yang

et al. 2021

Preprint

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Purpose The aim of the study was to evaluate the prognostic value of free fatty acid (FFA) and high-density lipoprotein cholesterol (HDL-C) in predicting colorectal neuroendocrine tumours (NETs). Methods One hundred patients with pathologically diagnosed colorectal NETs in 2011-2017 were enrolled, and the levels of FFA, HDL-C, low-density lipoproteincholesterol (LDL-C), triglycerides (TGs), cholesterol (CHOL), apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) between colorectal NET patients and healthy controls matched by age and sex were compared. In addition, the association of clinicopathological characteristics and follow-up data with FFA and HDL-C was analysed. Results FFA was overexpressed (0.55±0.23 vs. 0.48±0.11, P= 0.006) and HDL-C was underexpressed (1.31±0.41 vs. 1.41±0.29, P=0.046) in colorectal NETs. FFA ≥0.52 mmol/L predicted lymph node metastasis (LNM) (χ2 = 5.964, P=0.015), and HDL-C ≤1.0 mmol/L predicted tumour size ≥2 cm (χ2 = 5.647, P=0.017). No significant association was found between FFA and tumour size (P=0.142) or HDL-C and LNM (P=0.443). FFA ≥0.52 mmol/L (χ2 = 6.016, P=0.014) and HDL-C ≤1.0 mmol/L predicted worse overall survival (OS) (χ2 = 5.488, P=0.019). FFA ≥0.52 mmol/L in combination with HDL-C ≤1.0 mmol/L predicted an even worse prognosis in terms of OS (χ2 = 4.818, P=0.028). Conclusion FFA ≥0.52 mmol/L and HDL-C ≤1.0 mmol/L were promising cut-off values in predicting LNM, tumour size and worse OS in colorectal NETs.

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Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study

Cited by 4 publications

References 24 publications

Plasma Bacterial DNA Load as a Potential Biomarker for the Early Detection of Colorectal Cancer: A Case–Control Study

Plasma Bacterial DNA Load as a Potential Biomarker for the Early Detection of Colorectal Cancer: A Case–Control Study

Lipid-Based Factors: A Promising New Biomarker for Predicting Prognosis and Conditional Survival Probability in Hepatocellular Carcinoma

Combined Detection of Free Fatty Acid (FFA) and High-Density Lipoprotein Cholesterol (HDL-C) is a Promising Pretreatment Biomarker for Predicting the Overall Prognosis (OS) of Neuroendocrine Tumours (NETs) in the Colorectum: A Case-Control Study.

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