Free radical processes in aging, neurodegenerative diseases and other pathological states

Dubinina, E. E.; Pustygina, A. V.

doi:10.1134/s1990750807040026

Cited by 12 publications

(8 citation statements)

References 150 publications

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“…In recent studies, free radical damage and the antioxidant defense system in humans are reported to have pathogenic effects on neural tissue and important factors in the development of various neurologic and psychiatric diseases. 21,22 Oxidative stress markers, such as TAS, TOS and OSI values in psychiatric disorders, are investigated in many studies and conflicting data have emerged on this issue. In one study, TOS was higher in schizophrenia than in controls, therewithal TOS and OSI were higher and TAS was lower in patients in remission than those without.…”

Section: Oxidative Stress In Ocdmentioning

confidence: 99%

Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Alici¹,

Bülbül

Virit

et al. 2015

Psychiatry Clin Neurosci

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Aims: There are limited published data about the role of oxidative stress in the pathophysiology of obsessive-compulsive disorder (OCD). In addition, oxidative stress and oxidative DNA damage have not been investigated together in OCD. In this study, we aimed to evaluate oxidative stress and oxidative DNA damage in patients with OCD.Methods: Forty-two patients with OCD who were diagnosed in the Psychiatry Clinic of Gaziantep University and 38 healthy volunteers were enrolled in the study. Serum 8-hydroxideoxiguanosine (8-OHdG), total antioxidant status, total oxidant status evaluation and oxidative stress index calculation were conducted in Gaziantep University Biochemical Laboratory.Results: There were no significant differences in the total antioxidant status, total oxidant status and oxidative stress index levels between the patients and control group. However, 8-OHdG levels were significantly higher in OCD patients than controls (P = 0.022). In addition, 8-OHdG levels were significantly lower in patients who took treatment than in patients who were newly diagnosed (P = 0.016). Conclusions:In our study, we found that oxidative DNA damage increased in OCD patients even though oxidative stress was normal. In addition, DNA damage was lower in patients who were treated compared to those without treatment.

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Section: Oxidative Stress In Ocdmentioning

confidence: 99%

Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Alici¹,

Bülbül

Virit

et al. 2015

Psychiatry Clin Neurosci

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“…Patients are considered to be resistant to treatment if they are not adequately treated with SS-RIs with a tolerable maximum dose for at least 3 months [27]. Free radicals and antioxidant defense system disorders result in pathogenic effects on human neural tissues; hence they are known to be important factors in the development of various brain disorders [28][29][30][31][32]. OCD may be associated with free radicals [33,34].…”

Section: Introductionmentioning

confidence: 99%

Effect of selenium as an adjunctive therapy in patients with treatment-resistant obsessive-compulsive disorder: A pilot randomized double blind placebo-controlled clinical trial

Sayyah¹,

Andishmand²,

Ganji³

2018

Arch Psych Psych

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Background: The first line medicinal treatment of obsessive-compulsive disorder (OCD) includes selective serotonin reuptake inhibitors (SSRIs). Researchers have shown that there is a correlation between a deficiency of trace elements, the trace elements deficiency such as selenium, and mental disorders and mood,-Since selenium is a safe supplement with a favorable side effect profile, it may be useful as an adjunctive treatment with SSRIs. Aim: To determine if adjunctive selenium therapy improves symptoms in treatment-resistant OCD. Methods: Thirty-two patients with treatment-resistant OCD were selected and randomly assigned to two groups: intervention and control, with both groups continuing to receive SSRI drugs according to current guidelines. The intervention group received one 200 mcg selenium capsule daily while the control group received one placebo capsule each day for 6 weeks. Results: Y-BOCS scores decreased at the end of the sixth week in both groups, but this reduction was significantly lower in the selenium group (P = 0.01). Selenium was well tolerated and there was no significant difference between the two groups in the incidence of side effects. Conclusion: The results of this study indicate that selenium, as an adjunctive treatment with SSRIs, improves symptoms of OCD and thus can be used as a new drug for treatment-resistant OCD.

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“…В совокупности с неблагоприятными факторами окружающей среды, несбалансированное питание, наличие вредных привычек, а также частые длительные стрессы приводят к чрезмерному образованию в организме АФК или, так называемому, оксидативному стрессу. АФК наносят организму большой вред, повреждая клеточные мембраны, окисляя молекулы ДНК, РНК, белков, фосфолипидов, вызывая в конечном итоге мутации или гибель клеток [2,3,5,13].…”

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Direct Effect Food Ingredients in Bakery Products Technology

Паймулина¹,

Калинина²,

Науменко³

et al. 2018

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Калинина Ирина Валерьевна, кандидат технических наук, доцент, Южно-Уральский государственный университет (г. Челябинск). Науменко Наталья Владимировна, кандидат технических наук, доцент кафедры «Пищевые и биотехнологии», Южно-Уральский государственный университет (г. Челябинск),

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Free radical processes in aging, neurodegenerative diseases and other pathological states

Cited by 12 publications

References 150 publications

Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Effect of selenium as an adjunctive therapy in patients with treatment-resistant obsessive-compulsive disorder: A pilot randomized double blind placebo-controlled clinical trial

Direct Effect Food Ingredients in Bakery Products Technology

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