Free‐radical scavenging activities of silybin and its analogues: A pulse radiolysis study

Fu, Haiying; Lin, Mingzhang; Katsumura, Yosuke; Muroya, Yusa

doi:10.1002/kin.20589

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Fu and others () used pulse radiolysis to evaluate the • OH‐scavenging activity of 3 flavanones: naringin (5), hesperetin (6), and naringenin (7). The rate constants and thus the • OH‐scavenging activity trended downward in the same order.…”

Section: Flavonoidsmentioning

confidence: 99%

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Flavonoids as Potent Scavengers of Hydroxyl Radicals

Treml

Šmejkal

2016

Comp Rev Food Sci Food Safe

338

166

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Oxidative stress is a fundamental principle in the pathophysiology of many diseases. It occurs when the production of reactive oxygen species exceeds the capacity of the cell defense system. The hydroxyl radical is a reactive oxygen species that is commonly formed in vivo and can cause serious damage to biomolecules, such as lipids, proteins, and nucleic acids. It plays a role in inflammation-related diseases, like chronic inflammation, neurodegeneration, and cancer. To overcome excessive oxidative stress and thus to prevent or stop the progression of diseases connected to it, scientists try to combat oxidative stress and to find antioxidant molecules, including those that scavenge hydroxyl radical or diminish its production in inflamed tissues. This article reviews various methods of hydroxyl radical production and scavenging. Further, flavonoids, as natural plant antioxidants and essential component of the human diet, are reviewed as compounds interacting with the production of hydroxyl radicals. The relationship between hydroxyl radical scavenging and the structure of the flavonoids is discussed. The structural elements of the flavonoid molecule most important for hydroxyl radical scavenging are hydroxylation of ring B and a C2-C3 double bond connected with a C-3 hydroxyl group and a C-4 carbonyl group. Hydroxylation of ring A also enhances the activity, as does the presence of gallate and galactouronate moieties as substituents on the flavonoid skeleton.

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Section: Flavonoidsmentioning

confidence: 99%

“…Compound 5 showed the greatest activity, probably due to the presence of a sugar moiety with several hydroxyl groups. Fu and others () also performed a theoretical elucidation of the SAR. They calculated the O‐H bond dissociation energies (BDE) of the hydroxyl groups in the flavanones.…”

Section: Flavonoidsmentioning

confidence: 99%

Flavonoids as Potent Scavengers of Hydroxyl Radicals

Treml

Šmejkal

2016

Comp Rev Food Sci Food Safe

338

166

View full text Add to dashboard Cite

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“…This shows that naringin can effectively inhibit the occurrence of non-enzymatic browning in sprouts. Related studies have shown that naringin has excellent antioxidant and free radical scavenging ability, which can effectively reduce the production of free radicals in the organism [ 35 , 36 ]. The use of naringin forms an antioxidant film on the surface of the sprouts, which reacts preferentially with oxygen.…”

Section: Discussionmentioning

confidence: 99%

Effects of Naringin on Postharvest Storage Quality of Bean Sprouts

Yang

Zhao

Gu³

et al. 2022

Foods

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This study investigated the effects of naringin on soybean and mung bean sprouts postharvest quality. It was found that naringin could maintain the appearance and quality of soybean sprouts and mung bean sprouts during a 6-day storage period as well as delay the occurrence of browning in mung bean sprouts and soybean sprouts. The optimal application rate of naringin was 50–100 μg/mL, which could effectively inhibit the activity of polyphenol oxidase (PPO) and peroxidase (POD) in bean sprouts and increase the ascorbic acid content, where this inhibition response to the browning of mung bean sprouts and soybean sprouts was significantly reduced. Naringin treatment increased gallic acid and p-coumaric acid content in mung bean sprouts as well as the daidzin and rutin content in soybean sprouts, which was also reflected in the improvement of antioxidant activity. The binding of naringin with PPO and POD was analyzed with molecular docking, naringin, and PPO had a lower binding energy (−1.09 Kcal/mol). In conclusion, naringin application in postharvest preservation of mung bean sprouts and soybean sprouts can maintain favorable consumer quality.

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Assessing the antioxidant properties of Naringin and Rutin and investigating their oxidative DNA damage effects in breast cancer

Pravin,

Nanaware,

Ashwini

et al. 2024

Sci Rep

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This work examines the capacity of Naringin and Rutin to influence the DNA damage response (DDR) pathway by investigating their interactions with key DDR proteins, including PARP-1, ATM, ATR, CHK1, and WEE1. Through a combination of in silico molecular docking and in vitro evaluations, we investigated the cytotoxic and genotoxic effects of these compounds on MDA-MB-231 cells, comparing them to normal human fibroblast cells (2DD) and quiescent fibroblast cells (QFC). The research found that Naringin and Rutin had strong affinities for DDR pathway proteins, indicating their capacity to specifically regulate DDR pathways in cancer cells. Both compounds exhibited preferential cytotoxicity towards cancer cells while preserving the vitality of normal 2DD fibroblast cells, as demonstrated by cytotoxicity experiments conducted at a dose of 10 µM. The comet experiments performed particularly on QFC cells provide valuable information on the genotoxic impact of Naringin and Rutin, highlighting the targeted initiation of DNA damage in cancer cells. The need to use precise cell models to appropriately evaluate toxicity and genotoxicity is emphasized by this discrepancy. In addition, ADMET and drug-likeness investigations have emphasized the pharmacological potential of these compounds; however, they have also pointed out the necessity for optimization to improve their therapeutic profiles. The antioxidant capabilities of Naringin and Rutin were assessed using DPPH and free radical scavenging assays at a concentration of 10 µM. The results confirmed that both compounds have a role in reducing oxidative stress, hence enhancing their anticancer effects. Overall, Naringin and Rutin show potential as medicines for modulating the DDR in cancer treatment. They exhibit selective toxicity towards cancer cells while sparing normal cells and possess strong antioxidant properties. This analysis enhances our understanding of the therapeutic uses of natural chemicals in cancer treatment, supporting the need for more research on their mechanisms of action and clinical effectiveness.

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Free‐radical scavenging activities of silybin and its analogues: A pulse radiolysis study

Cited by 3 publications

References 32 publications

Flavonoids as Potent Scavengers of Hydroxyl Radicals

Flavonoids as Potent Scavengers of Hydroxyl Radicals

Effects of Naringin on Postharvest Storage Quality of Bean Sprouts

Assessing the antioxidant properties of Naringin and Rutin and investigating their oxidative DNA damage effects in breast cancer

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