Free Radicals and Gastrointestinal Disorders

Brown, Kirsty; Molcan, Erin; Rajendiran, Ethendhar; Nusrat, Angela; Baker, John; Ruscheinsky, Stephanie; Gibson, Deanna L.

doi:10.1007/978-3-642-30018-9_137

Cited by 8 publications

(7 citation statements)

References 192 publications

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“…Several studies suggested that oxidative stress plays an important role in IBS by being an active contributor to its development and its chronicity [12,33]. Our recent studies in stress exposure-based IBS animal models showed that oxidative stress changes could also occur in the brain [16,17] and intestinal tissues [34].…”

Section: Discussionmentioning

confidence: 99%

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Preliminary Study on the Tears Oxidative Stress Status and Sleep Disturbances in Irritable Bowel Syndrome Patients

Balmuș

Cojocariu

Ciobîcă

et al. 2020

Oxidative Medicine and Cellular Longevity

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According to the latest gastrointestinal disorders diagnostic criteria (ROME IV), the irritable bowel syndrome (IBS) is mainly characterized by the presence of abdominal pain and changes in intestinal transit. However, both sleep impairments and oxidative status changes (in patients’ sera, mucosal level, and other body fluids) were reported IBS. Thus, in this study, we aimed to evaluate several aspects regarding the oxidative stress status in patients’ tears as well as sleep disturbances by comparison with the intensity of IBS symptoms, as assessed by the visual analogue scale for irritable bowel syndrome (VAS-IBS). Ten IBS patients and fourteen healthy sex- and age-matched volunteers were recruited from the Oftaprof Ophthalmological Clinic (Iași, Romania). Visual analogue scale for irritable bowel syndrome and the Pittsburgh Sleep Quality Index (PSQI) questionnaires were administered to all the patients. Tear samples were collected using the Schirmer test procedure and were subjected to biochemical analysis—superoxide dismutase and glutathione peroxidase activities, malondialdehyde, and total soluble proteins levels were determined. Standard statistical analysis was applied. We found significant differences in oxidative stress marker dynamics in IBS patients as compared to healthy age- and sex-matched controls: increased superoxide dismutase activity (p=0.02), increased malondialdehyde (p=0.007), and total soluble proteins levels (p=0.019). We found no significant differences in tear glutathione peroxidase activity in IBS patients as compared to healthy age- and sex-matched controls (p=0.55). Furthermore, we observed that the oxidative stress tear markers are correlated with gastrointestinal symptoms severity (as evaluated by VAS-IBS) but not correlated to the sleep quality index and items (as evaluated by PSQI), with significant differences according to patient sex and IBS subtype stratification. In this way, this study brings additional evidence of the oxidative stress role in IBS pathology alongside the evaluation of tear fluid molecular dynamics in IBS for the first time in our best knowledge.

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Section: Discussionmentioning

confidence: 99%

“…Oxidative changes were also documented in several biological fluids in IBS patients [12][13][14]. In this way, oxidative stress was shown to be significant in both systemic and mucosal levels as a result of innate immune dysfunction in IBS pathogenesis [15].…”

Section: Introductionmentioning

confidence: 98%

Preliminary Study on the Tears Oxidative Stress Status and Sleep Disturbances in Irritable Bowel Syndrome Patients

Balmuș

Cojocariu

Ciobîcă

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Nonetheless, HFD induces IBD, CD, and UC mainly by promoting oxidative damage, which acts as a signal that initiates barrier damage and submucosal inflammation ( Aviello & Knaus, 2017 ). In the gut, ROS are regularly produced in response to micronutrient metabolisms and various cells, including epithelial, immune, and endothelial cells ( Brown, 2014 ). Other resources of ROS include external foreign substances and pathogenic bacteria ( Bhattacharyya et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…In the case of HFD feeding, the accumulation of CHOL, TGs, and free fatty acids, as well as oxidized fats, trigger ROS by alerting the microbiota population, inducing lipid peroxidation, scavenging antioxidants, promoting endoplasmic reticulum (ER) stress, and generating toxic mediators such as bile acids ( Gruber et al, 2013 , Hildebrandt et al, 2009 , Schulz et al, 2014 , Zhao et al, 2020 ). These ROS not only damage the membrane of the cell by peroxidation of lipids, DNA, and proteins but also alter membrane fluidity and impair the mucosal membrane barrier, thus stimulating the invasion of the bacteria and subsequently activation of mucosal resident leukocytes ( Brown, 2014 , Li et al, 2012 , Wang et al, 2020 ). These inflammatory cells further increase ROS production, leading to positive activation feedback and sustained stress due to oxidation as well as inflammation ( Wang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Zingerone attenuates intestinal injury and colitis caused by a high-fat diet through Nrf2 signaling regulation

BinMowyna

2023

Saudi Journal of Biological Sciences

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“…In the GI tract, the luminal surface is exposed to trillions of microbes, the highest amount of bacteria compared to other mucosal surfaces in the body. ROS are generated during various metabolic and physiological processes and play a double role in the biological system [19]. At lower concentrations, ROS plays an important role in physiological and cellular responses in the body, such as fighting against infectious mediators and regulating a number of cellular signaling pathways, including gene transcription, protein kinase activation, and phosphatase inhibition.…”

Section: Oxidative Stress As a Contributing Factor Of Gi Diseasesmentioning

confidence: 99%

Effects of Alkaline-Reduced Water on Gastrointestinal Diseases

et al. 2022

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Living a healthy lifestyle is the most important need in the world today. However, oxidative stress (OS) is caused by several stress-inducing factors such as smoking, alcohol consumption, chronic diseases, and inflammatory responses, oxygen-free radicals are produced in excess and can damage major organs in the body. This phenomenon has been implicated in the pathogenesis of several gastrointestinal (GI) diseases, including gastritis, constipation, and inflammatory bowel diseases, which include Crohn’s disease, ulcerative colitis, functional dyspepsia, acid reflux, diverticular disease, and irritable bowel syndrome. In this review article, we provide a brief overview of the role of OS in the pathogenesis of GI disorders. Additionally, we discuss the therapeutic role of alkaline-reduced water (ARW) on GI diseases and existing studies on ARW related to GI diseases. Furthermore, we believe that findings from this review article will enhance the knowledge of the readers on the role of ARW on OS and inflammation-based GI diseases.

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Free Radicals and Gastrointestinal Disorders

Cited by 8 publications

References 192 publications

Preliminary Study on the Tears Oxidative Stress Status and Sleep Disturbances in Irritable Bowel Syndrome Patients

Preliminary Study on the Tears Oxidative Stress Status and Sleep Disturbances in Irritable Bowel Syndrome Patients

Zingerone attenuates intestinal injury and colitis caused by a high-fat diet through Nrf2 signaling regulation

Effects of Alkaline-Reduced Water on Gastrointestinal Diseases

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