Free radicals, lipid peroxidation and the antioxidant system in the blood of cows and newborn calves around calving

Gaál, T.; Ribiczeyné-Szabó, P.; Stadler, Krisztián; Jakus, Judit; Reiczigel, Jenő; Kövér, Pál; Mézes, Miklós; Sümeghy, L.

doi:10.1016/j.cbpb.2005.12.014

Cited by 119 publications

(121 citation statements)

References 26 publications

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“…During our experiment, the SOD activities were gradually elevated, which was probably caused by a response of the organism to higher superoxide generation, especially after calving. Although the SOD activity increases after calving in dairy cows (Gaál et al 2006), several recent studies have shown that the antioxidant capacity in peripartal dairy cows is insufficient to counteract the increase in ROS supply (Bernabucci et al 2005;Castillo et al 2005). In our study, reduction in GSH-Px activity one week after calving could be supported as increasing postpartal oxidative stress.…”

Section: Discussionsupporting

confidence: 55%

Oxidative stress and antioxidant status in dairy cows during prepartal and postpartal periods

et al. 2015

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The aim of the present study was to evaluate the indicators of oxidative stress (malondialdehyde [MDA]) and antioxidant status (ferric reducing ability of plasma [FRAP]; superoxide dismutase [SOD]; glutathione peroxidase [GSH-Px]; selenium [Se]; vitamin E) in dairy cows of the Slovak Pied cattle from 3 weeks before parturition to 9 weeks after parturition. The mean MDA concentration was significantly (P < 0.001) higher in the cows 1 week after calving compared to the cows 3, 6, and 9 weeks after calving. The lowest mean FRAP value was found in the cows 3 weeks after parturition. The SOD activities were increased during the whole monitored time (ANOVA, P < 0.001). A significant (P < 0.05) decrease of GSH-Px activities was recorded in the cows 1 week after calving compared to the weeks 6 and 9 after calving. Statistical multiple comparison test showed no significant changes in Se between the examined groups. The lowest mean vitamin E concentration was found in the first week after parturition. Significantly positive correlations (P < 0.05) were recorded between Se and vitamin E (r = 0.897), SOD and GSH-Px (r = 0.903), while Se and GSH-Px had no significantly positive correlation (r = 0.520). Significant changes between MDA and indicators of oxidative stress (SOD, GSH-Px, vitamin E) confirm that during parturition and onset of lactation, oxidative stress occurs in dairy cows. Exposure of peripartal cows to oxidative stress may cause an increased incidence of metabolic diseases.

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Section: Discussionsupporting

confidence: 55%

Oxidative stress and antioxidant status in dairy cows during prepartal and postpartal periods

et al. 2015

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“…Similarly, another study (Oztabak et al 2005) has shown that while plasma GSH-Px activities in pregnant ewes on days 148 of pregnancy were higher than in the non-pregnant ewes, plasma CAT activities were lower and plasma TBARS concentrations were not different. Gaál et al (2006) reported that no significant differences were found in the MDA concentration and GSH-Px activity in red blood cells at calving compared to the pre-and post-calving periods in dairy cows, but significantly higher superoxide dismutase activity. There are conflicting reports regarding antioxidant activity changes throughout gestation in humans and rats.…”

Section: Discussionmentioning

confidence: 93%

Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

2009

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Pregnancy is a condition that favours oxidative stress. The aim of this study was to evaluate the oxidant and antioxidant status by measuring glutathione peroxidase (GSH-Px), catalase (CAT) activities and malondialdehyde (MDA) and glutathione (GSH) concentrations before and during pregnancy in ewes. Twelve healthy female and two healthy male Awassi sheep, aged 4-5 years, weighing approximately 50 -55 kg each, were used in the study. The ewes' blood samples were taken before synchronization and during pregnancy (on 25 th days of each month of pregnancy). Plasma MDA concentrations in the 2 nd and 3 rd months of pregnancy in ewes were lower than in the 1 st , 4 th , 5 th months of pregnancy and in the non-pregnant ewes. GSH concentrations and GSH-Px activities during pregnancy were increased (P < 0.01). GSH concentrations and GSH-Px activities were the highest in the 2 nd and 3 rd months of pregnancy. CAT activities were decreased after the 1 st month of pregnancy in ewes (P < 0.001). They were the lowest in the 2 nd and 3 rd months of pregnancy. The findings of our study show decreased CAT activities and elevated GSH concentrations and GSH-Px activities after the 1 st month of pregnancy in ewes. These changes in the indicators under study may indicate a predisposition to oxidative stress in the 2 nd and 3 rd month of pregnancy in ewes. Awassi sheep, pregnancy, oxidant and antioxidant status

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“…The diminished PON1 activity in postpartum could be caused by a low oxidative status (Gaál et al 2006). The elevated PON1/HDL ratio is a result of decreased HDL levels.…”

Section: Discussionmentioning

confidence: 99%

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Kulka¹,

Kołodziejska-Lesisz²,

Kluciński³

2016

Polish Journal of Veterinary Sciences

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We investigated the measurement of paraoxonase 1 (PON1), as a potential marker of redox state changes in dairy cows, its involvement in lipid metabolism and compared it with superoxide dismutase (SOD) activity changes. We also evaluated lipid metabolism parameters associated with dairy production. PON1 paraoxonase and arylesterase acitvities, SOD activity, beta-hydroxybutyrate (BHB), uric acid (UA), high density lipoprotein (HDL), low density lipoprotein (LDL), cholesterol and triglyceride concentrations were measured in Holstein-Friesian, Polish Red and Norwegian breeds serum in two production cycles. Our data showed a significant postpartum depletion in PON1 activity and lipoprotein and lipid products concentrations, with elevated BHB values. However, there were no significant changes in SOD activity and uric acid concentrations in Holstein-Friesian and Polish Red breeds after calving. At lactation peak there was a significant SOD activity decrease correlated with standardized PON1 activity depletion in all examined breeds. The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.

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Free radicals, lipid peroxidation and the antioxidant system in the blood of cows and newborn calves around calving

Cited by 119 publications

References 26 publications

Oxidative stress and antioxidant status in dairy cows during prepartal and postpartal periods

Oxidative stress and antioxidant status in dairy cows during prepartal and postpartal periods

Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

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