Free Radicals Scavenging and Neuroprotective Effects of Ethanolic Leaf Extract of Combretum zenkeri Leaf

Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri

“…Although, in a few cases the activity of their mixture in other pharmacological activities has shown to be greater than that of the single compounds, 26,27 and extensive data about the synergistic antimalarial activity of these two isomers is lacking. Some studies have recently described ursolic acid as a pentacyclic triterpenoid with a wide spectrum of pharmacological activities such as protective effect on lungs, kidneys, liver and brain, anti-inflammatory properties, anabolic effect on skeletal muscles, antiosteoporosis, antimicrobial effect against numerous strains of bacteria, anti HIV and HCV viruses and antimalarial among others 28,29,30 Consequently, it is plausible to suggest that the presence of ursolic acid in C. zenkeri contribute hugely to the different pharmacological actions [13][14][15][16] exerted by the plant. However, it is important to widely explore C. zenkeri for its other bioactive constituents which may be useful lead compounds or scaffolds necessary for their synthesis for many other pharmacological investigations important.…”

“…10 In Western Nigeria, Combretum zenkeri leaves are used in the treatment of inflammatory diseases like rheumatoid-arthritis, and the roots used frequently in recipes for managing cancer. 11,12 In previous studies, several pharmacological investigations for Combretum zenkeri such as nephro-protective effect, 13 hepatoprotective effect, 14 anti-oxidative activity and neuro-protective effect 15 and cytotoxic activity 12 have been validated. In our more recent study, preliminary screening of 10 Combretaceae species showed that Combretum zenkeri possessed antimalarial activity.…”

Organic wastes of Citrus sinensis Peels- a source of eco-friendly and sustainable bioactive compounds for promoting health

“…Antioxidants are molecules that protect cells from damage resulting from free radicals which are unstable molecules that can cause oxidative stress and contribute to chronic diseases. Antioxidants are able to neutralize free radicals which include oxygen, nitrogen and lipid radicals, while protecting biological system and organism" [10]. Natural antioxidants (such as phenolic compounds, vitamins and carotenoids [11,12] are considered safer and healthier compared to synthetic antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PG), tertbutylhydroquinone (TBHQ), ascorbic acid and gallic acid esters.…”