Free testosterone and dehydroepiandrosterone sulfate serum levels in polycystic ovary syndrome women

Mostafa, Rowaa A.; Al-Sherbeeny, Mohmmed Mahmoud; Abdelazim, Ibrahim A.; Khalifa, Ayman M.; Fahmy, Alaa; Ahmed, Nour El-Din

doi:10.18869/nrip.jamsat.3.1.17

Cited by 5 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results in table (1) show a significant increase differences in DHES when compared patients with control group compared at p < 0.001. These results were in agreement with some previous studies [11][12][13] Who showed the abnormally high levels of DHEA-S occur in about 20-30% of women with PCOS.…”

Section: Resultssupporting

confidence: 94%

Dipeptidyl Peptidase 4 in Women with Polycystic Ovarian Syndrome

2020

MLU

View full text Add to dashboard Cite

Background: Polycystic ovary syndrome (PCOS) is the most prevalent reproductive endocrinopathy and currently considered to be a part of the metabolic syndrome. Women suffering from PCOS present with a group of symptoms related with menstrual disorder and androgen excess. Women with PCOS cluster risk factors associated with risk of insulin resistance, dyslipidemia, hyperandrogenemia, obesity, cardiovascular disease (CVD), infertility, and psychological disorders. Objective :The study was designed to determine the levels of DPP4 in PCOS patients and compared with control and study the correlation with biomarkers in serum of PCOS patients. Subjects and Method:The study is case-control included 80 females and carried out from February 2019 till May 2019 for females in the reproductive age [18-45 years old], forty females were came from gynecological and obstetric hospital, in Karbala, and they all diagnosed by their physicians have polycystic ovarian syndrome and compared with forty control females {healthy females]. plasma activity of DPP4 and biochemical variables were performed. Results:Results obtained in this study showed that there are significant differences (p < 0.05) in serum of DPP4, SHBG, DHEA-S, LH, FSH, free testosterone and total testosterone and there is positive significant correlation between DPP4 with free testosterone, SHBG, DHEA-S, LH and total testosterone. Conclusion:Polycystic ovarian syndrome is a higher risk of type 2 diabetic mellitus, dyslipidemia and cardiovascular diseases, Dipeptidyl peptidase 4 (DPP4) was high in PCOS patient and had positive correlation with free testosterone, total testosterone, DHEA-S, SHBG and LH.

show abstract

Section: Resultssupporting

confidence: 94%

Dipeptidyl Peptidase 4 in Women with Polycystic Ovarian Syndrome

2020

MLU

View full text Add to dashboard Cite

show abstract

“…Mostafa et al reported manifestation of hyperandrogenism in 70% of PCOS women [5]. Mostafa et al in another study reported excess ovarian androgen in 50% of PCOS women and excess adrenal androgen (detected by DHEAs) in 30% of PCOS women [12].…”

Section: Discussionmentioning

confidence: 99%

“…Mostafa et al suggested measurement of free and total testosterone to detect the ovarian source of hyperandrogenism and measurement of DHEAs to detect the adrenal source of hyperandrogenism in PCOS women [12].…”

Section: Discussionmentioning

confidence: 99%

Elevated and diagnostic androgens of polycystic ovary syndrome

Abdelazim

Alanwar

Abu-Faza

et al. 2020

View full text Add to dashboard Cite

Introduction: A genetic variation at the level of aromatase enzyme and/or androgen receptors was suggested in polycystic ovary syndrome (PCOS).Aim of the study: To determine the androgens elevated and diagnostic for PCOS. Material and methods: A total of 120 PCOS women were compared to non-PCOS controls in this study. The studied women were evaluated thoroughly, including: day 2-3 hormonal profile and any hormonal change confirmed by two laboratory results eight weeks apart. Collected data were analysed to determine the androgens elevated and diagnostic for PCOS.Results: The luteinising hormone (LH) and LH/follicle stimulating hormone (FSH) ratio were significantly high in the studied PCOS group compared to controls (p = 0.02 and 0.01, respectively). In addition, total and free testosterone and androstenedione were significantly high in the studied PCOS group compared to controls (p = 0.001, 0.003, and 0.02, respectively).The studied PCOS group had higher relative risk (RR) and odds ratio (OR) of elevated total testosterone (2.4 and 5.7, respectively), elevated free testosterone (2.9 and 4.9, respectively), and elevated androstenedione (3.0 and 4.8, respectively), compared to controls.Conclusions: Testosterone (both total and free testosterone) and androstenedione were the main elevated androgens and were diagnostic for excess ovarian androgens in the studied PCOS women, whereas dehydroepiandrosterone (DHEA) was not elevated and/or diagnostic for excess ovarian androgens in the studied PCOS women.

show abstract

“…[4] Mostafa et al , in another study reported excess androgen in 50% of PCOS women and they suggested the use of free and total testosterone to detect excess ovarian androgen production in PCOS. [10]…”

Section: Discussionmentioning

confidence: 99%

Abdelazim and Sakiyeva endocrinopathy associated with polycystic ovary syndrome: Case reports

Abdelazim

Kanshaiym

2019

J Family Med Prim Care

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a multiple endocrine disorder associated with significant reproductive and metabolic manifestations. A genetic variation at the level of aromatase enzyme gene (CYP19 gene) and/or androgen receptors with subsequent increased ovarian androgen was suggested in PCOS. Recently, researchers noted that 56% of the PCOS women had evidence of hypothyroidism and this report represents three case of PCOS with hypothyroidism and hyperprolactinemia (Abdelazim and Sakiyeva endocrinopathy associated with PCOS) to highlight the hypothyroidism and hyperprolactinemia as a common endocrinopathy associated with PCOS. PCOS women should be screened for the endocrinopathy associated with PCOS especially the hypothyroidism and hyperprolactinemia because the undiagnosed endocrinopathy aggravates the PCOS symptoms.

show abstract

Free testosterone and dehydroepiandrosterone sulfate serum levels in polycystic ovary syndrome women

Cited by 5 publications

References 13 publications

Dipeptidyl Peptidase 4 in Women with Polycystic Ovarian Syndrome

Dipeptidyl Peptidase 4 in Women with Polycystic Ovarian Syndrome

Elevated and diagnostic androgens of polycystic ovary syndrome

Abdelazim and Sakiyeva endocrinopathy associated with polycystic ovary syndrome: Case reports

Contact Info

Product

Resources

About