Free triiodothyronine/free thyroxine (FT3/FT4) ratio is strongly associated with insulin resistance in euthyroid and hypothyroid adults: a cross-sectional study

Štěpánek, Ladislav; Horáková, D; Štěpánek, Lubomír; Janout, Vladimí­r; Janoutová, Jana; Bouchalová, Kateřina; Martiník, Karel

doi:10.5603/ep.a2020.0066

Cited by 25 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…What we are unable to interpret is the unexpected correlation of TSH and fT3, a parameter of less clinical significance than TSH and fT4 [ 39 ] in some subgroups of women with PCOS ( Supplementary Table S1 ). However, this significantly elevated fT3 concentration was found in subpopulations of women with significantly elevated 120 min 75 OGTT insulin, which reflects the results of other studies [ 40 ], suggesting that fT3 could be an indicator of insulin resistance development. Despite an evidently higher incidence of insulin resistance and hyperlipidemia in the PCOS-SCH subpopulation, the expected associated higher testosterone level, higher FAI, higher mFG scale score, and higher prevalence of polycystic ovarian morphology have not been demonstrated, which is in line with the findings of other studies, with a few exceptions [ 41 ].…”

Section: Discussionsupporting

confidence: 89%

Association of Subclinical Hypothyroidism with Present and Absent Anti-Thyroid Antibodies with PCOS Phenotypes and Metabolic Profile

Gawron

Baran

Derbisz

et al. 2022

JCM

View full text Add to dashboard Cite

Background: Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) often coexist, but implications of the co-occurrence of two disorders have not yet been established. The objective is to conclude whether SCH with present or absent anti-thyroid antibodies (ATA) impacts on the PCOS phenotype and alters biochemical or clinical parameters. Methods: A retrospective cohort study was conducted in a tertiary reference center. Clinical and biochemical parameters of women with PCOS were analyzed. Results: A total of 367 women with PCOS were included in the study, 114 (31.1%) of whom were diagnosed with SCH and 16 (4.4%) with autoimmune thyroiditis (AIT). Among all parameters studied, the strongest relationship with SCH was confirmed for insulin resistance and dyslipidemia. SCH was an independent risk factor for insulin resistance. In SCH the additional presence of ATA did not exacerbate the metabolic disorders. There was no significant association of any PCOS phenotype with SCH, nor with the presence of circulating ATA. There was no significant difference in hormonal parameters and mFerriman–Gallwey scale score between women with PCOS with and without SCH. Conclusions: SCH alters metabolic, but not hormonal, parameters in PCOS. The diagnosis of SCH does not exclude the diagnosis of PCOS. The potential effect of positive ATA was insignificant.

show abstract

Section: Discussionsupporting

confidence: 89%

Association of Subclinical Hypothyroidism with Present and Absent Anti-Thyroid Antibodies with PCOS Phenotypes and Metabolic Profile

Gawron

Baran

Derbisz

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…These results indicate the importance of determining and monitoring free hormones ratio as an additional parameter that can help clinicians in assessing thyroid function. Also, more studies indicate a significant relationship between FT3/FT4 ratio and other diseases (39,40). The FT3 / FT4 ratio would be useful in everyday practice.…”

Section: Discussionmentioning

confidence: 97%

Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer

Mirjanic-Azaric¹,

Milinković²,

Bogavac-Stanojević³

et al. 2022

J Med Biochemistry

View full text Add to dashboard Cite

Background: The aim of this study was to determine the reference intervals (RIs) for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and FT3/FT4 ratio using indirect methods. Methods: We analysed 1256 results TSH, FT4 and FT3 collected from a laboratory information system between 2017 and 2021. All measurements were performed on a Siemens ADVIA Centaur XP analyser using the chemiluminescent immunoassay. We calculated the values of the 2.5th and 97.5th percentiles as recommended by the IFCC (CLSI C28-A3). Results: The RIs derived for TSH, FT4, FT3 and FT3/FT4 ratio were 0.34-4.10 mIU/L, 11.3-20.6 pmol/L, 3.5-6.32 pmol/L and 0.21-0.47, respectively. We found a significant difference between calculated RIs for the TSH and FT4 and those recommended by the manufacturer. Also, FT3 values were significantly higher in the group younger than 30 years relative to the fourth decade (5.26 vs. 5.02, p=0.005), the fifth decade (5.26 vs. 4.94, p=0.001), the sixth decade (5.26 vs. 4.87, p˂0.001), the seventh decade (5.26 vs. 4.79, p˂0.001) and the group older than 70 years old (5.26 vs. 4.55, p˂0.001). Likewise, we found for TSH values and FT3 / FT4 ratio a significant difference (p <0.001) between different age groups. Conclusions: The establishing RIs for the population of the Republic of Srpska were significantly differed from the recommended RIs by the manufacturer for TSH and FT4. Our results encourage other laboratories to develop their own RIs for thyroid parameters by applying CLSI recommendations.

show abstract

“…A negative correlation between fT3 levels and the fT3/fT4 ratio and the presence of peripheral artery disease was found among the euthyroid Chinese population [32], which also is in agreement with our results. In contrast, recent studies have revealed that a higher fT3/fT4 ratio is a significant predictor of insulin resistance and metabolic syndrome [33,34], which can contribute to higher CV risk. However, in our study we found an inverse correlation of fT3/fT4 with cIMT.…”

Section: Discussionmentioning

confidence: 98%

Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Łukawska-Tatarczuk

Zieliński²,

Franek

et al. 2022

Endokrynol Pol

View full text Add to dashboard Cite

opment of diabetic complications, of which the most significant association is suspected in CV complication in T1DM [3]. It seems that an imbalance in the immune system may be a key trigger of processes underlying atherosclerosis, which include inflammation [4], endothelial dysfunction [5], and accumulation of prothrombotic factors [6]. Interestingly, autoimmune factors in CV complications appear to be particularly relevant in women. It was found that the antioxidant and anti-inflammatory effects of oestrogen observed in healthy women are due to the regulatory Th2, macrophage, and T regulatory cell immune response and are probably disrupted in the presence of autoimmune Endokrynologia Polska

show abstract

Free triiodothyronine/free thyroxine (FT3/FT4) ratio is strongly associated with insulin resistance in euthyroid and hypothyroid adults: a cross-sectional study

Cited by 25 publications

References 23 publications

Association of Subclinical Hypothyroidism with Present and Absent Anti-Thyroid Antibodies with PCOS Phenotypes and Metabolic Profile

Association of Subclinical Hypothyroidism with Present and Absent Anti-Thyroid Antibodies with PCOS Phenotypes and Metabolic Profile

Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer

Is thyroid autoimmunity associated with subclinical atherosclerosis in young women with type 1 diabetes mellitus?

Contact Info

Product

Resources

About