Freeze-dried chitosan matrices for slow-release of acetogenins extracted from soursop (Annona muricata L.) leaves

In vitro studies of Annona muricata L. extract‐loaded electrospun scaffolds for localized treatment of breast cancer

“…[14][15][16] A few researchers have reported the successful loading of AME extracts into drug delivery carriers to potentiate their cytotoxic effects through their sustained release to the target cells. [17][18][19] For instance, Aruan et al 17 incorporated AME leaf extracts into electrospun polyvinyl alcohol nanofiber scaffolds and demonstrated the cytotoxic effects of the released extracts on the growth of Staphylococcus aureus. Similar effects were exhibited by AME extracts loaded in liposomes and phytosmes 18 and freeze-dried matices.…”

“…Similar effects were exhibited by AME extracts loaded in liposomes and phytosmes 18 and freeze-dried matices. 19 However, these studies did not report on the release profiles and release kinetics of AME from the drug carriers, which are important for optimizing the drug delivery systems to facilitate the localized delivery of AME at desirable doses over longer durations to cancer cells. Hence, this work studied the release profiles and release kinetics of AME from different AME-eluting electrospun scaffold formulations.…”