Freezing of gait in PD

Giladi, Nir; McDermott, Michael P.; Fahn, Stanley; Przedborski, Serge; Jankovic, Joseph; Stern, Matthew B.; Tanner, Caroline M.

doi:10.1212/wnl.56.12.1712

Cited by 481 publications

(437 citation statements)

References 28 publications

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“…The convergent and divergent reliability of the Brazilian version of the FOG-Q was very similar to that observed in other studies, showing that patients with PD and FOG have more balance and gait problems and worse parkinsonian axial motor signs 17,21 . Because these symptoms directly interfere with mobility and social life, this may be one way by which FOG negatively affects quality of life 22,23 .…”

Section: Discussionsupporting

confidence: 85%

Validity of the Brazilian version of the freezing of gait questionnaire

Baggio

Curtarelli

Rodrigues

et al. 2012

Arq. Neuro-Psiquiatr.

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OBJECTIVE: To validate the freezing of gait questionnaire (FOG-Q) for a Brazilian population of Parkinson's disease (PD) patients. METHODS: One hundred and seven patients with a diagnosis of PD were evaluated by shortened UPDRS motor scale (sUPDRm), Hoehn and Yahr (HY), Schwab and England scale (SE), Berg balance scale (BBS), falls efficacy scale international (FES-I), gait and balance scale (GABS), and the FOG-Q Brazilian version. RESULTS: 47.7% of PD patients had FOG episodes; this group had worse scores on sUPDRSm, FOGQ, FES-I, BBS, GABS and FOG item of UPDRS when compared to the PD group without FOG. The internal consistency was 0.86, intra-rater 0.82 and inter-rater 0.78. The FOG-Q Brazilian version was significantly correlated with items related to gait and balance. The ROC curve was 0.94, the sensitivity was 0.90and specificity was 0.92. CONCLUSION: Our study suggests that the FOG-Q Brazilian version is a reliable and valid instrument for assessing FOG in PD patients.

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Section: Discussionsupporting

confidence: 85%

Validity of the Brazilian version of the freezing of gait questionnaire

Baggio

Curtarelli

Rodrigues

et al. 2012

Arq. Neuro-Psiquiatr.

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“…the "OFF" period). Immediately afterwards, the FOG scale by Giladi et al 12,13 , which was recently translated into Portuguese 14 , was applied to all patients during the "OFF" period. Patients were instructed to use their re gular diurnal dose of levodopa and were evaluated with the aforementioned scales after an hour.…”

Section: Scales and Testsmentioning

confidence: 99%

Vascular parkinsonism: a case series of 17 patients

Vale

Caramelli

Cardoso

2013

Arq. Neuro-Psiquiatr.

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Objective To report the clinical and neuroimaging findings in a case series of vascular parkinsonism (VP). Methods Seventeen patients with VP were evaluated with motor, cognitive, and neuroimaging standardized tests and scales. Results All patients had arterial hypertension. Ten patients were male and the mean age of the whole sample was 75.8±10.1 years. The mean age of parkinsonism onset was 72.2±10.0 years. Common clinical features were urinary incontinence (88.2%), lower limb parkinsonism with freezing of gait and falls (82.3%), and pyramidal signs (76.4%). The mean Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn-Yahr scores were 72.5±21.6 points and 3.3±0.9 points, respectively. Sixteen (94.1%) patients had freezing of gait and executive dysfunction. Twelve (70.5%) patients had probable vascular dementia. The mean dose of levodopa was 530.9 mg/day. Unresponsiveness to the drug was confirmed by a 6.9 mean point reduction in the UPDRS score after the “practically defined off” test. Conclusion This series provides a profile of VP with predominant lower-limb involvement, freezing of gait and falls, pyramidal signs, executive dysfunction, concomitant vascular dementia, and poor levodopa response.

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“…Gait impairment in the form of shuffling, short steps, or freezing often occurs during the course of Parkinson disease (PD), generating substantial disability [1]. It is well recognized that auditory, visual, or tactile stimuli can improve gait in patients with PD [2].…”

Section: Introductionmentioning

confidence: 99%

At-home training with closed-loop augmented-reality cueing device for improving gait in patients with Parkinson disease

Espay¹,

Baram²,

Dwivedi³

et al. 2010

JRRD

135

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Abstract-Shuffling and freezing while walking can impair function in patients with Parkinson disease (PD). Open-loop devices that provide fixed-velocity visual or auditory cues can improve gait but may be unreliable or exacerbate freezing of gait in some patients. We examined the efficacy of a closedloop, accelerometer-driven, wearable, visual-auditory cueing device in 13 patients with PD with off-state gait impairment at baseline and after 2 weeks of twice daily (30 minute duration) at-home use. We measured gait velocity, stride length, and cadence using a validated electronic gait-analysis system. Subjects underwent standard motor assessment and completed a self-administered Freezing of Gait Questionnaire (FOGQ) (range 0-24; lower is better). After training, device use enhanced walking velocity (61.6 ± 20.1 cm/s to 72.6 ± 26.5 cm/s, p = 0.006) and stride length (74.3 ± 16.4 cm to 84.0 ± 18.5 cm, p = 0.004). Upon device removal, walking velocity (64.5 ± 21.4 cm/s to 75.4 ± 21.5 cm/s, p < 0.001) and stride length (79.0 ± 20.3 cm to 88.8 ± 17.7 cm, p = 0.003) exhibited a greater magnitude of change, suggesting immediate residual benefits. Also upon device removal, nearly 70 percent of subjects improved by at least 20 percent in either walking velocity, stride length, or both. An overall improvement in gait was measured by the FOGQ (14.2 ±1.9 to 12.4 ± 2.5, p = 0.02). Although issues related to compliance and response variability render a definitive interpretation of study outcome difficult, devices using closed-loop sensory feedback appear to be effective and desirable nonpharmacologic interventions to improve walking in selected individuals with PD.

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Freezing of gait in PD

Cited by 481 publications

References 28 publications

Validity of the Brazilian version of the freezing of gait questionnaire

Validity of the Brazilian version of the freezing of gait questionnaire

Vascular parkinsonism: a case series of 17 patients

At-home training with closed-loop augmented-reality cueing device for improving gait in patients with Parkinson disease

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