Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion’s Disease in Amazonas, Peru

Abstract

Carrion's disease (CD), is a human bartonellosis, that is, endemic in the Andes of Peru, Ecuador, and Colombia. Bartonella bacilliformis, a native hemotrophic bacteria, is the causative agent of CD, and the interaction with the host could have produced changes in the gene frequencies of erythrocyte antigens. The goal here is to investigate the relationship between allele frequencies of blood group systems MNS, Diego, and Duffy and the clinical phases of CD, within a genetic context. In this associative and analytical study, 76 individuals from Bagua Grande, the province of Utcubamba, and the department of Amazonas in Peru, were enrolled. Forty of them resided in Tomocho-Collicate-Vista Hermosa area (high prevalence of cases in chronic phase, verrucous, or eruptive phase, without previous acute phase). Thirty-six individuals were from the area of Miraflores (high prevalence of cases in acute phase only) and were evaluated for blood group systems MNS, Diego, and Duffy. This study constitutes one of the first attempts at evaluating the genetic factors and clinical phases of CD. No significant statistical differences (P > 0.05) between allele frequencies of blood groups MNS, Diego, and Duffy and the prevalence of chronic and acute phases were detected in the two areas of Amazonas, Peru.

Blood Groups in Infection and Host Susceptibility

“…In areas of Peru, there are differences in clinical B. bacilliformis infection, with some populations being more likely to develop Carrion's disease (Oroya fever), whereas in others, the verrucous or eruptive phase (Peruvian wart) is predominant (544). A recent epidemiologic study compared the incidence and presentation of B. bacilliformis relative to the Duffy, MN, Ss, and Diego (Di a / b ) blood types (544). There was no difference in Di a expression between individuals with Oroya fever and those in the verrucous phase (15% versus 19%).…”

The Study of Some Possible Risk Factors for Arterial Thrombosis in the Example of Georgian Patients

“…Based on this, we have allocated 3 phenotypes (M group, N group, and MN group) in the control cohort and the patients. There is little information about MN blood group correlation with some kind of infectious disease [53,54].…”

Molecular identification of Bartonella bacilliformis in ticks collected from two species of wild mammals in Madre de Dios: Peru

“…In addition, the disease resurgence in areas of extreme poverty has become an challenge to the country in terms of vector control and disease burden reduction [11, 14, 15]. Lutzomyia verrucarum is the most effective vector in Peru, with occasional outbreaks in nonendemic areas in which other species of Lutzomyias have been described, such as L. maranonensis , L. robusta , and L. Peruensis suggesting Lutzomyias species adaptation to different climates and heights [16–18].…”