Frequencies of human platelet antigens (HPA-1, -2, -3, -4, and -5) among the Moroccan blood donors

Abstract

Aims: Human platelet antigens (HPA) are involved in several clinical conditions, such as neonatal alloimmune thrombocytopenia (NAIt), platelet transfusion purpura (PtP), and refractoriness to platelet transfusion.the frequency of platelet antigens varies among populations. so far, typing of HPA systems has not been carried on Moroccan population. the frequencies of these antigens, their risk of alloimmunization, and their clinical implications and complications within Moroccan population are unknown. Our purpose is to define allele frequencies and genotypes in Moroccan population of the five HPA-1 to HPA-5 systems. Evaluate of the risk of anti-platelet alloimmunization among Moroccan blood donors, and estimate the mismatch probability of different platelet alloantigens, after

Genotyping of Eight Human Platelet Antigen Systems in Serbian Blood Donors: Foundation for Platelet Apheresis Registry

“…Research of HPA allele frequencies and study of HPA antigen distribution differences between various ethnic populations are conducted to better understand the association between alloimmunization to these antigens and their clinical importance [8]. There are a number of studies reporting distributions of HPA gene frequencies in worldwide populations, which exhibit great variations between different ethnic and geographic groups [10].…”

“…Similarly, statistically significant differences were not encountered between the Serbian population and data from non-Finnish European populations from the gnomAD database [23], or other European populations [10]. There are, however, significant differences between the Serbian population and some populations of non-European origin, as exemplified by populations from Asia [10, 14], Africa [8, 10], and South America [10].…”

“…As expected, the HPA-4b allele was not identified in our population in this study. It is already established that the HPA-4b allele is not common, if present at all, among populations of European or African origin, but it is more frequent among Asian populations [8, 14, 24]. According to the available published reports, populations are usually homozygous for allele a in HPA-4 and HPA-6 systems.…”

“…Antiplatelet antibodies related to an incompatibility between the platelet donor and the recipient, or between the mother and the fetus during pregnancy, could initiate platelet destruction, which may consequently result in the occurrence of severe hemorrhagic disorders [8]. In European populations, alloantibodies are most commonly developed against HPA-1, HPA-2, and HPA-5 antigens.…”