The mammalianauditorysystemincludesabrainstem-mediatedefferentpathwayfromthesuperiorolivarycomplexbywayofthemedialolivocochlear system,whichreducesthecochlearresponsetosound (WarrandGuinan,1979;Libermanetal.,1996).Thehumanmedialolivocochlearresponsehasan onsetdelayofbetween25and40msandriseanddecayconstantsintheregionof280and160ms,respectively(BackusandGuinan,2006).Physiological studies with nonhuman mammals indicate that onset and decay characteristics of efferent activation are dependent on the temporal and level characteristics of the auditory stimulus (Bacon and Smith, 1991; Guinan and Stankovic, 1996). This study uses a novel psychoacoustical masking technique usingaprecursorsoundtoobtainameasureoftheefferenteffectinhumans.Thistechniqueavoidsconfoundscurrentlyassociatedwithotherpsychoacousticalmeasures.Bothtemporalandleveldependencyoftheefferenteffectwasmeasured,providingacomprehensivemeasureoftheeffectofhuman auditoryefferentsoncochleargainandcompression.Resultsindicatethataprecursor(Ͼ20dBSPL)inducedefferentactivation,resultinginadecrease in both maximum gain and maximum compression, with linearization of the compressive function for input sound levels between 50 and 70 dB SPL. Estimatedgaindecreasedasprecursorlevelincreased,andincreasedasthesilentintervalbetweentheprecursorandcombinedmasker-signalstimulus increased, consistent with a decay of the efferent effect. Human auditory efferent activation linearizes the cochlear response for mid-level sounds while reducing maximum gain.