Frequency Analysis for The Effect of Pico Tesla-Transcranial Magnetic Stimulation in Epilepsy Patients Using Magnetoencephalography

Abstract

The purpose of this research is to identify any change in the frequencies of 2-7Hz in the brain state of epilepsy patients after pico-Tesla transcranial magnetic stimulation (pT-TMS). It is a noninvasive technique for treating neurological disorders. We used magneto encephalographic (MEG) recordings of 10 epilepsy patients with a whole-head 122 -channel MEG system in a magnetically shielded room of low magnetic noise. The subjects were 5 male and 5 female epilepsy volunteers between 18-42 years of age. Afterwards, external pT-TMS was applied to the above patients. A software program was developed in our lab in order to detect the primary dominant frequency of the power spectra of the MEG obtained from every patient and channel before and after the application of pT-TMS. We found that 7 out of 10 patients (70%) had increased their 2-7Hz frequencies after the application of pT-TMS. We concluded that frequency analysis is a promising means for the assessment of epilepsy disorders.

The pineal and thymus gland interaction on the immune system stimulation, through the melatonin hormone effect

“…This was done in order to help the PG release the melatonin hormone at normal levels. 6,[8][9][10][11][12][13] By this way we were able to influence the TG to produce the proper antibodies to destroy any foreign organisms invading in the human organism. 6,15 However, in order to avoid the patients to get and use the electronic device for decalcification of the PG for the normal production of melatonin hormone, as an hypothesis we could administer melatonin orally, by pills that are now widely available in drugstores, in very low doses.…”

“…Through the application of a software program developed in our laboratory we were able to detect the amplitude of the primary dominant frequency in the power spectrum of the MEG obtained from every patient. 8,10 By using FFT we could obtain maps for those frequencies from the power spectra on the MEG data from each patient. Different colors on the maps represent different dominant frequencies.…”

“…In this way we can see the effect before and after the use of pT-TMS in every patient with calcified (Figure 5) PG 14 and thus impaired melatonin secretion (see figures 1-4) as an increase of the θ and δ (pathological) frequencies towards the alpha (normal) frequencies, as what we have already published. 8,10 Figure 1 Power spectra of the 122 channel MEG.…”

“…As it was published 6 it has 10 epitope-binding sites making it fierce adversary. 6,7 As part of our previous studies with magneto encephalographic (MEG) recordings for the beneficial effect of the application of external pT-TMS on several Central Nervous System (CNS) diseases, 6,[8][9][10][11][12][13] the crucial role of the proper function of PG on the immunity was revealed and the importance of not to be calcified. 6 In case where the PG was impaired i.e calcified (Figure 5) the melatonin secretion was partially prevented.…”

Analyzing the Effect of Weak External Transcranial Magnetic Stimulation on the Primary Dominant Frequencies of Alzheimer Patients Brain by Using MEG Recordings

“…This device is a 122-coil helmet, arranged in five groups disposition, which covers the main 7 brain areas of the patient (Table 1) and is designed to create pT-TMS range modulations of magnetic flux in the alpha frequency range (8-13 Hz) for every patient [14]. The pT-TMS device format is to produce a square wave equivalent to the neuron's interaction or communication in the brain [15][16][17][18][19][20].…”