2008
DOI: 10.1002/jmv.21314
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Frequency and genotype of GB virus C among Iranian patients infected with HIV

Abstract: GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus (HIV) due to similar transmission routes of these viruses. The aim of this study was to determine the rate of infection and genotypic characteristics of GBV-C in this population. The presence of GBV-C RNA was determined in serum samples of 106 patients infected with HIV by reverse transcriptase-nested polymerase chain reaction. GBV-C genotypes were determined by direct sequencing. Hepatitis B surface antigen (HB… Show more

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Cited by 12 publications
(14 citation statements)
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“…This was not unexpected; the current sequences came from either Kuwaiti or Jordanian nationals, which should geographically belong to the Asian genotypes 3 or 4. But because similar phylogenetic results were obtained in previous studies conducted in Middle Eastern countries neighboring both Kuwait and Jordan, UAE [7] , Saudi Arabia [4] and Iran [8] , where genotype 2 was also prevalent, we were more convinced that our results were genuine (as can be seen in the phylogenetic analysis).…”
Section: Discussionsupporting
confidence: 74%
See 2 more Smart Citations
“…This was not unexpected; the current sequences came from either Kuwaiti or Jordanian nationals, which should geographically belong to the Asian genotypes 3 or 4. But because similar phylogenetic results were obtained in previous studies conducted in Middle Eastern countries neighboring both Kuwait and Jordan, UAE [7] , Saudi Arabia [4] and Iran [8] , where genotype 2 was also prevalent, we were more convinced that our results were genuine (as can be seen in the phylogenetic analysis).…”
Section: Discussionsupporting
confidence: 74%
“…Other sequences from neighboring Middle Eastern countries were included for comparison purposes: Iran (IR1, IR2, IR4; accession Nos. EU714767, EU714768, EU714770, respectively) [8] , Saudi Arabia (KSA; accession Nos. AF133506, AF133507, AF133508, AF133510, and AF133518) [4] , and United Arab Emirates (UAE-1 through UAE-4) [7] .…”
Section: Genotypic and Phylogenetic Analysesmentioning
confidence: 99%
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“…En la Tabla 1 se resumen las características y principales hallazgos de diferentes estudios epidemiológi-cos en los que se ha analizado el efecto de la co-infección GBV-C/VIH; en el este de África, estudios en cohortes de pacientes infectados por el VIH sin terapia anti-retroviral, revelan tasas de co-infección de 25,7% en asintomáticos, y 10.9% en pacientes sintomáticos 22 . Una frecuencia similar se encontró en un estudio de corte transversal realizado en 106 pacientes iraníes, de los cuales 12 (11,3%) presentaron infección simultanea por el GBV-C y aunque no hubo diferencia estadísticamente significativa, en este grupo de co-infectados hubo menos individuos que necesitaron terapia HAART (25 vs 43,6%); en este trabajo se determinó además que todos los aislados pertenecían al GBV-C genotipo 2a 23 . Aunque existen pocos estudios de caracterización genotípica del GBV-C en pacientes co-infectados con VIH, se ha reportado que el genotipo 2 es el más frecuente en esta población 24 .…”
Section: Co-infección Gbv-c/vihunclassified
“…There are higher GBV-C infection rates among immunocompromised individuals. Depending on the population, GBV-C co-infection with HCV varies from 11% to 43.6% [3][4][5][6][7], from 14% to 36% with HIV-1 [8], and from 30 to 36% with HIV/HCV [9,10].…”
Section: Introductionmentioning
confidence: 99%