Frequency and relevance of concomitant diseases in elderly patients hospitalized for community acquired pneumonia

Djuric, M.; Povazan, Djordje; Sečen, Nevena; Perin, Branislav

doi:10.2298/sarh0912619d

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Although sensitivity analysis was performed by excluding the retrospective observational studies, the influence of methodological quality (study design) on bias was still unknown. Moreover, four cohort studies [34][35][36][37] and one case-control study 38 were included in the metaanalysis, in which one cohort study 34 did not document the ascertainment of CAP, and the other four studies divided CAP patients into patients who died or patients who survived, and were thus excluded from our review. In addition, that meta-analysis focused exclusively on mortality, the other clinically important outcomes including length of hospital stay, ICU admission and need for mechanical ventilation were not investigated.…”

Section: Discussionmentioning

confidence: 99%

Is COPD associated with increased mortality and morbidity in hospitalized pneumonia? A systematic review and meta‐analysis

et al. 2015

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This review aimed to investigate whether chronic obstructive pulmonary disease (COPD) is associated with increased mortality and morbidity in patients hospitalized with community-acquired pneumonia (CAP). EMBASE,PubMed and Web of Science were searched for cohort studies and case-control studies investigating the impact of COPD on CAP. The primary outcome was all-cause mortality, and secondary outcomes included length of hospital stay, intensive care unit (ICU) admission and need for mechanical ventilation. Methodological quality was assessed using the Newcastle-Ottawa Scale. The Mantel-Haenszel method and inverse variance method were used to calculate pooled relative risks (RRs) and mean differences (MD), respectively. Eleven studies (nine cohort studies and two casecontrol studies), involving 257 958 patients, were included. The overall methodological quality was high. COPD was not associated with increased mortality in hospitalized CAP patients (RR, 1.20; 95% confidence interval (CI): 0.92-1.56; P = 0.19; I 2 = 55%) in cohort studies, and was associated with reduced mortality in case-control studies (RR, 0.82; 95% CI: 0.74-0.90; P < 0.0001; I 2 = 80%). COPD was not associated with longer hospital stay (MD, 0.11; 95% CI: −0.42 to 0.64; P = 0.68; I 2 = 21%), more frequent ICU admission (RR, 0.97; 95% CI: 0.70-1.35; P = 0.87; I 2 = 65%), and more need for mechanical ventilation (RR 0.91, 95% CI: 0.71-1.16; P = 0.44; I 2 = 4%).The current available evidence indicates that COPD may not be associated with increased mortality and morbidity in patients hospitalized with CAP. This conclusion should be re-evaluated by prospective population-based cohort studies.

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Section: Discussionmentioning

confidence: 99%

Is COPD associated with increased mortality and morbidity in hospitalized pneumonia? A systematic review and meta‐analysis

et al. 2015

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“…We identified 13 relevant studies with 394 832 participants for inclusion in this analysis . Patients tended to be > 60 years of age, and predominantly male.…”

Section: Resultsmentioning

confidence: 99%

“…Assessment of study quality found that one was a post hoc analysis of a trial , five were retrospective observational studies , and seven were prospective observational studies . Radiographic confirmation of pneumonia was reported in 11 studies , while one study relied on International Classification of Disease (ICD‐10) codes , and another did not specify the exact method . COPD case definition was less certain, with only five studies explicitly specifying spirometric criteria, either before or after the pneumonia episode .…”

Section: Resultsmentioning

confidence: 99%

Chronic obstructive pulmonary disease and mortality from pneumonia: meta-analysis

et al. 2013

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Community-acquired pneumonia

Milutinović-Matić¹,

Marić²,

Blagojević³

et al. 2018

Opšta medicina

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In the period from 01.11.2014 to 01.05.2015, there were 33 diagnosed pneumoniae. Associated illnesses, in population older than 65 years, were present in 92.85% of patients and some of them had two or three comorbidities. CРB65 proved itself as a good parameter in assessment of the disease severity for both groups. Applied antibiotic therapy proved to be effectiv in 80% of patients. Тhere is no significant difference in pneumonia presentation with regards to gender and age. In data proccessing, descriptive statistics methods and no parameter X 2 test were used for statistical significance assessment. Conclusion: All patients with clear indications should be hospitalized, but large percentage of patients can be treated in outpatints` facilities, with good patient cooperation. Also vaccination, as an available resource, seems to have not received a significant place in our environment.

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Frequency and relevance of concomitant diseases in elderly patients hospitalized for community acquired pneumonia

Cited by 3 publications

References 11 publications

Is COPD associated with increased mortality and morbidity in hospitalized pneumonia? A systematic review and meta‐analysis

Is COPD associated with increased mortality and morbidity in hospitalized pneumonia? A systematic review and meta‐analysis

Chronic obstructive pulmonary disease and mortality from pneumonia: meta-analysis

Community-acquired pneumonia

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