Frequency and temporal evolution of COVID-19 vaccination rate among oncological patients undergoing 18F-FDG-PET

Skawran, Stephan; Schiesser, Helen; Maurer, Alexander; Sartoretti, Thomas; Dittli, Manuel; Mader, Cäcilia; Curioni-Fontecedro, Alessandra; Berger, Christoph; Huellner, Martin W.; Messerli, Michael

doi:10.1016/j.vaccine.2022.10.089

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Although accurate nodal staging is advantageous, reactive lymph nodes due to in ammation can cause false-positive results in FDG-PET/CT assessments (4,5). The in uence of COVID-19 vaccination on FDG-PET/CT has been reported in several studies and cohort analyses (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Examination of iatrogenic FDG accumulation after COVID-19 vaccination

Takahashi,

Manabe,

Shizukuishi

et al. 2024

Ann Nucl Med

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This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT). Materials and methodsWe evaluated 285 patients who underwent PET/CT between June and September 2021 and had a known history of COVID-19 vaccination. Information on the injection site, vaccine type, and adverse reactions was obtained. We visually assessed the presence or absence of accumulation in the axillary and supraclavicular lymph nodes and the deltoid muscles. We measured the maximum standardized uptake value (SUVmax) using semi-quantitative analysis. ResultsOur study included 158 males and 127 females aged 16 to 94 years. The median time between vaccination and PET/CT was nine and 42 days for patients who had received their rst and second doses, respectively. We observed axillary lymph node accumulation, supraclavicular lymph node accumulation, and deltoid muscle accumulation in 99 (SUVmax 1.07-25.1), nine (SUVmax 2.28-14.5), and 33 cases (SUVmax 0.93-7.42), respectively. In cases with axillary lymph node (P = 0.0066) or deltoid muscle (P = 0.047) accumulation, the shorter the time since vaccination, the higher the FDG accumulation. Patients with axillary lymph node accumulation were signi cantly younger (P < 0.0001) and had a signi cantly higher frequency of adverse reactions such as fever (P < 0.0001) and myalgia (P = 0.001). Logistic regression analysis also showed that age, sex, days since vaccination, and adverse reactions such as fever and myalgia were important factors for axillary lymph node accumulation. ConclusionOur study found that FDG accumulation in the axillary lymph nodes and deltoid muscle was higher within a shorter time after vaccination, and axillary lymph node accumulation was higher in young patients, females, and those with adverse reactions of fever and myalgia. Con rming the vaccination status, time since vaccination, and the presence of adverse reactions before PET may reduce false positives.

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Section: Introductionmentioning

confidence: 99%

Examination of iatrogenic FDG accumulation after COVID-19 vaccination

Takahashi,

Manabe,

Shizukuishi

et al. 2024

Ann Nucl Med

View full text Add to dashboard Cite

show abstract

Examination of iatrogenic FDG accumulation after COVID-19 vaccination

Takahashi,

Manabe,

Shizukuishi

et al. 2023

Preprint

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Purpose This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT). Materials and methods We evaluated 285 patients who underwent PET/CT between June and September 2021 and had a known history of COVID-19 vaccination. Information on the injection site, vaccine type, and adverse reactions was obtained. We visually assessed the presence or absence of accumulation in the axillary and supraclavicular lymph nodes and the deltoid muscles. We measured the maximum standardized uptake value (SUVmax) using semi-quantitative analysis. Results Our study included 158 males and 127 females aged 16 to 94 years. The median time between vaccination and PET/CT was nine and 42 days for patients who had received their first and second doses, respectively. We observed axillary lymph node accumulation, supraclavicular lymph node accumulation, and deltoid muscle accumulation in 99 (SUVmax 1.07–25.1), nine (SUVmax 2.28–14.5), and 33 cases (SUVmax 0.93–7.42), respectively. In cases with axillary lymph node (P = 0.0066) or deltoid muscle (P = 0.047) accumulation, the shorter the time since vaccination, the higher the FDG accumulation. Patients with axillary lymph node accumulation were significantly younger (P < 0.0001) and had a significantly higher frequency of adverse reactions such as fever (P < 0.0001) and myalgia (P = 0.001). Logistic regression analysis also showed that age, sex, days since vaccination, and adverse reactions such as fever and myalgia were important factors for axillary lymph node accumulation. Conclusion Our study found that FDG accumulation in the axillary lymph nodes and deltoid muscle was higher within a shorter time after vaccination, and axillary lymph node accumulation was higher in young patients, females, and those with adverse reactions of fever and myalgia. Confirming the vaccination status, time since vaccination, and the presence of adverse reactions before PET may reduce false positives.

show abstract

Frequency and temporal evolution of COVID-19 vaccination rate among oncological patients undergoing 18F-FDG-PET

Cited by 2 publications

References 12 publications

Examination of iatrogenic FDG accumulation after COVID-19 vaccination

Examination of iatrogenic FDG accumulation after COVID-19 vaccination

Examination of iatrogenic FDG accumulation after COVID-19 vaccination

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