Frequency-controlled wireless shape memory polymer microactuator for drug delivery application

Zainal, Mohammad Amri; Ahmad, Anuar; Ali, Mohamed Sultan Mohamed

doi:10.1007/s10544-017-0148-5

Cited by 33 publications

(20 citation statements)

References 24 publications

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“…The resonant frequency in these media exhibits an almost identical response, while different values of phase dip (Fig 4(a)) were observed in water and air. The PDMS encapsulation of the LC receiver circuit isolates the LC coil from the operating media 30 and hence maintaining its inductance, in contrast to the device reported by 31 with the resonant frequency shifted when changing from water and air. The difference value of the phase dip in water and air might be caused by the higher power absorption of water.…”

Section: Characterization Of the Fabricated Lc Receiver Circuitmentioning

confidence: 91%

Wirelessly activated device with an integrated ionic polymer metal composite (IPMC) cantilever valve for targeted drug delivery

et al. 2018

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This paper reports a wirelessly powered ionic polymer-metal composite (IPMC) soft actuator operated by external radio frequency (RF) magnetic fields for targeted drug delivery. A 183 μm thick IPMC cantilever valve was fitted with an embedded LC resonant circuit to wirelessly control the actuator when the field frequency is tuned to its resonant frequency of approximately 25 MHz. Experimental characterization of the fabricated actuator showed a cumulative cantilever deflection of 160 μm for three repeated RF ON-OFF cycles at 0.6 W input power. The device was loaded with a dye solution and immersed in DI water to demonstrate wireless drug release. The qualitative result shows the successful release of the dye solution from the device reservoir. The release rate can be controlled by tuning the RF input power. We achieved a maximum average release rate of ∼0.1 μl s-1. We further conducted an in vitro study with human tumor cells (HeLa) to demonstrate the proof of concept of the developed device. The experiments show promising results towards the intended drug delivery application.

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Section: Characterization Of the Fabricated Lc Receiver Circuitmentioning

confidence: 91%

Wirelessly activated device with an integrated ionic polymer metal composite (IPMC) cantilever valve for targeted drug delivery

et al. 2018

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“…Besides, Zainal et al. [ 181 ] demonstrated an SMPCs drug release system where drugs and the SMPCs component were separate entities. In their study, bulk SMP sealing with a drug reservoir was connected with a Cu resistor heater so that once the external electromagnetic field frequency was tuned to the resonant frequency of the heater, bulk SMP was activated with the drug being released into the environment.…”

Section: Recent Advances In Applications Of Smps and Smpcsmentioning

confidence: 99%

A Review of Shape Memory Polymers and Composites: Mechanisms, Materials, and Applications

et al. 2020

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Over the past decades, interest in shape memory polymers (SMPs) has persisted, and immense efforts have been dedicated to developing SMPs and their multifunctional composites. As a class of stimuli‐responsive polymers, SMPs can return to their initial shape from a programmed temporary shape under external stimuli, such as light, heat, magnetism, and electricity. The introduction of functional materials and nanostructures results in shape memory polymer composites (SMPCs) with large recoverable deformation, enhanced mechanical properties, and controllable remote actuation. Because of these unique features, SMPCs have a broad application prospect in many fields covering aerospace engineering, biomedical devices, flexible electronics, soft robotics, shape memory arrays, and 4D printing. Herein, a comprehensive analysis of the shape recovery mechanisms, multifunctionality, applications, and recent advances in SMPs and SMPCs is presented. Specifically, the combination of functional, reversible, multiple, and controllable shape recovery processes is discussed. Further, established products from such materials are highlighted. Finally, potential directions for the future advancement of SMPs are proposed.

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“…Shape memory polymer (SMP) is a kind of smart material, which can revert to the original shape from the deformed shape with the effect of outside stimulus like light [1], heat [2], electromagnetic field [3], specific ion [4] and so on. Compared with general materials and composite materials [5], SMP has excellent deformation ability, biodegradability, biocompatibility, and well manufacturing performance, so that it has wide application prospect in biomedicine [6] and aerospace [7] and electronic devices [8].…”

Section: Introductionmentioning

confidence: 99%

Constitutive model for epoxy shape memory polymer with regulable phase transition temperature

Zhao

Zheng

Zhou

et al. 2021

International Journal of Smart and Nano Materials

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The epoxy shape memory polymer (SMP) with adjustable phase transition temperature is a kind of high-performance shape memory polymer, which can change its phase transition temperature and improve its mechanical properties through the process of photo curing. An epoxy SMP constitutive model combining phase transition and viscoelasticity is established by discretizing the epoxy SMP into several glass phase units and rubbery phase units in this paper. The model includes the viscoelastic constitutive equations of glass phase units and rubber phase units, the parameter expression during shape memory process, and material parameter equation during photocuring process. And the stress relaxation behavior of epoxy SMP at different temperatures and the change of material parameters during the photo-curing process are simulated numerically, and the simulation results perform consistency with the experimental data. The model can not only relate shape memory effect and phase transformation in physics but also better characterize the viscoelastic properties of SMP and predict the shape memory response of SMP.

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Frequency-controlled wireless shape memory polymer microactuator for drug delivery application

Cited by 33 publications

References 24 publications

Wirelessly activated device with an integrated ionic polymer metal composite (IPMC) cantilever valve for targeted drug delivery

Wirelessly activated device with an integrated ionic polymer metal composite (IPMC) cantilever valve for targeted drug delivery

A Review of Shape Memory Polymers and Composites: Mechanisms, Materials, and Applications

Constitutive model for epoxy shape memory polymer with regulable phase transition temperature

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