Frequency of antibiotic resistance in Helicobacter pylori strains isolated from the northern population of Iran

Abstract

Objective The purpose of this study was to evaluate the primary resistance rates of recent clinical Helicobacter pylori isolates to the most commonly used antibiotics in Iran. Materials and Methods 210 patients presenting with gastric maladies between January and July of 2009 were enrolled in this study. Endoscopy was performed, and biopsy specimens were collected from each patient for subsequent bacterial culture of H. pylori. Single colony isolates from each patient were then used for antimicrobial susceptibility testing. The disk diffusion method was used to determine susceptibility patterns. Results 197 of the patients were H. pylori positive (93.8%). The rates of resistance to tetracycline, amoxicillin, ciprofloxacin, metronidazole, clarithromycin, and furizoladone were 37.1%, 23.9%, 34.5%, 65.5%, 45.2%, and 61.4%, respectively. A significant association between amoxicillin resistance and disease state (P <0.05) was identified. Furthermore, some double, triple, quadruple, and quintuple combinations of antibiotic resistance were found to be associated with disease state. Conclusions This study evaluated the prevalence of H. pylori resistance to the most commonly prescribed antibiotics used in Iran and showed that resistance rates were generally higher than previously reported. This data adds to the growing body of evidence that suggests there is increasing antibiotic resistance among H. pylori isolates, which likely is responsible for the decreasing efficacy of anti-H. pylori therapy at the local and global level. Hence, there is a need for continued monitoring of resistance patterns, especially at the local level, and for incorporation of that information into treatment regimens for H. pylori infections.

Platelet Count Response to Helicobacter Pylori Eradication in Iranian ‎patients With Idiopathic Thrombocytopenic ‎purpura

“…This rate similar to prevalence of H.pylori infection in the general population in Iran 5. These results also were comparable to those of previous studies which were done in Asian countries 6.…”

Evaluation of antimicrobial resistance of Helicobacter pylori in the last 15 years in West Poland

“…Our results have been confi rmed by other European data, documenting the level of resistance to amoxicillin of 0-0.9% [11]. A high proportion of primary amoxicillin resistance (13.6-59%) was detected in Africa, Asia and South America [12][13][14].…”

Molecular characterization and antibiotic susceptibility profiles of Helicobacter pylori isolated from patients with Gastrodeudenal diseases in Jordan

“…This is in agreement with most of the local and international studies which reported rates that are similar to our results However, the reported MIC values of clarithromycin resistant H. pylori in our study were higher. [38,39]. In a study conducted by PCR for the detection of point mutations associated with clarithromycin resistance, similar rates were reported in Jordan [31].…”