Frequency of azoospermia

Willott, G.M.

doi:10.1016/0379-0738(82)90099-8

Cited by 132 publications

(83 citation statements)

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“…28 The incidence of azoospermia in the general population is not known, but is often assumed to be 2%, mainly based on a study conducted on forensic evidence from 519 rape cases. 29 Compared to previous studies in patients with Hodgkin's lymphoma, our data showed better sperm quality than in some analyses, 6,30 but worse quality than in others. 7,31,32 Our study was, however, based on data from by far the largest series studied up date; this offered not only a more reliable estimation of sperm quality but also the opportunity to study factors influencing sperm quality.…”

Section: Discussioncontrasting

confidence: 78%

Sperm quality before treatment in patients with early stage Hodgkin's lymphoma enrolled in EORTC-GELA Lymphoma Group trials

Kaaij¹,

Heutte²,

Echten-Arends³

et al. 2009

Haematologica

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BackgroundAlthough widely recommended, cryopreservation of sperm is sometimes not performed for patients with Hodgkin's lymphoma because of presumed poor sperm quality related to the disease. We investigated sperm quality and factors determining it in untreated patients with early stage Hodgkin's lymphoma. Design and MethodsOf 2362 males who participated in EORTC H6-H9 trials, 474 (20%) had data available. Sperm quality was defined according to World Health Organization guidelines. Determining factors were studied by logistic regression analysis. ResultsThe median sperm concentration was 40×10 6 /mL (range, 0-345×10 6 /mL) and the median motility 50% (range, 0-90%). Sperm quality was good (concentration ≥20×10 6 /mL and motility ≥50%), intermediate (concentration ≥5×10 6 /mL) and poor (concentration <5×10 6 /mL but >0) in 41%, 49% and 7% of patients, respectively. Three percent of the patients were azoospermic. No relation was found between sperm quality and age or clinical stage of the Hodgkin's lymphoma, but B-symptoms and elevated erythrocyte sedimentation rate predicted poor sperm quality. The odds ratios for the association of poor sperm quality with the variables examined were: presence of B-symptoms, 2.77 (95% CI, 1.50-5.12; p=0.001); erythrocyte sedimentation rate of 50 mm/h or greater, 2.35 (95% CI, 1. p=0.009); fever, 3.22 (95% CI, p=0.005), and night sweats, 3.78 (95% CI, 1.97-7.26; p<0.001). There was no relation between sperm quality and pre-treatment follicle stimulating hormone level. ConclusionsIn this large study of males with Hodgkin's lymphoma, 90% had good or intermediate sperm quality. Three percent were azoospermic. There was an association between sperm quality and the presence or absence of B-symptoms, in particular fever and night sweats. With modern fertilization techniques, in most patients with early-stage Hodgkin's lymphoma sperm quality before treatment is good enough for future fatherhood.Key words: Hodgkin's lymphoma, fertility, male, sperm quality, sperm. Citation: van der

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Section: Discussioncontrasting

confidence: 78%

Sperm quality before treatment in patients with early stage Hodgkin's lymphoma enrolled in EORTC-GELA Lymphoma Group trials

Kaaij¹,

Heutte²,

Echten-Arends³

et al. 2009

Haematologica

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“…Azoospermia defined as the absence of spermatozoa in the ejaculate after assessment of centrifuged semen on at least two occasions, is observed in 1% of the general population and in 10-15% of infertile men [1,2]. Non-obstructive azoospermia (NOA) refers to absence of spermatozoa in semen analysis due to minimal or no production of fully developed spermatozoa in the testicles.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Human Chorionic Gonadotropin Treatment Before Testicular Sperm Extraction in Non-Obstructive Azoospermia

Gül¹

2016

Ann Clin Anal Med

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ÖzetAmaç: İdiyopatik non-obstrüktif azospermili (NOA) hastalarda, ampirik hCG tedavisi ile ilgili sonuçları araştırmak. Gereç ve Yöntem: hCG grubunu normal testis hacimlerine ve normal serum FSH ve LH düzeylerine sahip olan ve ampirik hCG ile tedavi edilen 34 hasta oluşturdu. hCG, testiküler sperm ekstraksiyonundan (TESE) 10-14 hafta önce 2500 IU olarak haftada iki kere deri altına enjeksiyon şeklinde uygulandı. Kontrol grubunu yaş ve eş yaşları hCG grubu ile denk olup aynı dönemde TESE uygulanan 49 hasta oluşturdu. Gruplar arasındaki sperm elde etme oranı (SRR), folikül uyarıcı hormon (FSH), luteinizan hormon (LH), testosteron seviyeleri, testis hacimleri, fertilizasyon oranları (FR), implantasyon oranları (IR), gebelik oranları (PR), canlı doğum oranları (LBR), iptal oranları (CR) ve cerrahi tekniği arasındaki ilişki değerlendirildi. Bulgular: Konvansiyonel teknik ile başarılı sperm elde edilmesi, hCG grubundaki 17 hasta'nın 14'ünde (% 82,3) olurken kontrol grubundaki 28 hasta'nın 18'inde (% 64,3) sağlandı (p = 0,170). SRR açısından gruplar arasında fark yoktu (p = 0,338). Hastaların yaşı, ortalama infertilite süresi, serum FSH, LH, testosteron, östradiol düzeyleri ve testis hacimleri açısından iki grup arasında anlamlı farklılık saptanmadı (p> 0,05). FR, IR, PR, LBR açısından iki grup arasında istatistiksel olarak anlamlı fark saptanmadı (p> 0,05). Tartışma: idiyopatik NOA hastalarda ampirik hCG tedavisi ile SRR iyileşme sağlanamamış-tır. hCG tedavisinin ICSI başarısı üzerinde herhangi bir etkisi bulunamamıştır. Anahtar KelimelerAzospermi; Hormon Tedavisi; Sperm Eldesi; Gebelik Oranı Abstract Aim: To investigate our experience on empirical hCG treatment of patients with idiopathic non-obstructive azoospermia (NOA). Material and Method: hCG group consisted of 34 patients who were empirically treated with hCG despite normal serum FSH and LH levels and normal testicular volumes. hCG was administered as 2500 IU twice weekly subcutaneous injections for 10 to 14 weeks prior to testicular sperm extraction (TESE). Control group consisted of 49 age and spouse age matched patients who underwent TESE in the same time period. Sperm retrieval rate (SRR), and follicle stimulating hormone (FSH), lutenizing hormone (LH) and testosterone levels, volume of testicles, fertilization rate (FR), implantation rate (IR), pregnancy rate (PR), live birth rate (LBR) and cancel rate (CR) and surgical technique were compared between the two groups. Results: Conventional technique was used in 14 of the 17 patients (82.3%) with successful sperm retrieval in the hCG group, and 18 of the 28 patients (64.3%) in the control group (p=0.170). There were no differences between groups in terms of SRR (p=0.338). There were no significant differences in patient age, mean infertility period, mean values of FSH, LH, testosterone, estradiol levels, and testis volume between the two groups (p>0.05). There were no statistically significant differences for FR, IR, PR, LBR between the two groups (p>0.05). Discussion: Empirical hCG treatment in patients wit...

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“…human | round spermatid | ROSI | azoospermia | male infertility A zoospermia, a condition in which there are no spermatozoa in the ejaculate, occurs in 1% of men in the general population (1). For men with obstructive azoospermia, microsurgical aspiration of epididymal spermatozoa has been performed, and the pregnancy rate following injection of oocytes with epididymal spermatozoa is comparable to that following injection of ejaculated spermatozoa (2).…”

mentioning

confidence: 99%

Fourteen babies born after round spermatid injection into human oocytes

Tanaka

Nagayoshi

Takemoto

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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During the human in vitro fertilization procedure in the assisted reproductive technology, intracytoplasmic sperm injection is routinely used to inject a spermatozoon or a less mature elongating spermatid into the oocyte. In some infertile men, round spermatids (haploid male germ cells that have completed meiosis) are the most mature cells visible during testicular biopsy. The microsurgical injection of a round spermatid into an oocyte as a substitute is commonly referred to as round spermatid injection (ROSI). Currently, human ROSI is considered a very inefficient procedure and of no clinical value. Herein, we report the birth and development of 14 children born to 12 women following ROSI of 734 oocytes previously activated by an electric current. The round spermatids came from men who had been diagnosed as not having spermatozoa or elongated spermatids by andrologists at other hospitals after a first Micro-TESE. A key to our success was our ability to identify round spermatids accurately before oocyte injection. As of today, all children born after ROSI in our clinic are without any unusual physical, mental, or epigenetic problems. Thus, for men whose germ cells are unable to develop beyond the round spermatid stage, ROSI can, as a last resort, enable them to have their own genetic offspring.

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Frequency of azoospermia

Cited by 132 publications

References 2 publications

Sperm quality before treatment in patients with early stage Hodgkin's lymphoma enrolled in EORTC-GELA Lymphoma Group trials

Sperm quality before treatment in patients with early stage Hodgkin's lymphoma enrolled in EORTC-GELA Lymphoma Group trials

The Effect of Human Chorionic Gonadotropin Treatment Before Testicular Sperm Extraction in Non-Obstructive Azoospermia

Fourteen babies born after round spermatid injection into human oocytes

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