Frequency of Complement Third Component (C3) and Properdin Factor (Bf) Phenotypes in Patients With Various Clinical Manifestations of HBV Infection

Abstract

Four groups of children were tested for the distribution of C3 and BF phenotypes: HBV-infected patients with Gianotti-Crosti syndrome, with CAH and with glomerulonephritis, and healthy children. The frequency of the phenotype C3F was significantly higher in children with Gianotti-Crosti syndrome in comparison with healthy children. The frequency of the phenotype BFS was significantly higher in patients with glomerulonephritis than in individuals with CAH. The difference between the frequency of the BFS phenotype in glomerulonephritis patients and that in healthy subjects neared significance. We suggest that the carriers of these phenotypes are characterized by susceptibility to some immune complex diseases associated with HBV infection.

Infection phase is a predictor of pruritus in patients with hepatitis B virus infection

“…Immune complexes targeting hepatitis B surface antigen are considered to cause immune reactions that result in the skin lesions in GCS (22). Additionally, a study described cutaneous changes with itching following IFN administration to treat HBV infection or hepatitis B vaccination (23).…”

Gianotti-Crosti Syndrome Caused by Acute Hepatitis B Virus Genotype D Infection

“…Further, several studies have indicated the participation of immunological mechanisms, such as the formation of immune complex (11,12).…”