Frequency of Cutaneous Disorders in Patients With Celiac Disease

Abstract

Background and objectiveCeliac disease is an autoimmune multisystem disorder that is triggered by dietary gluten sensitivity in genetically susceptible individuals. It presents with extraintestinal cutaneous manifestations including dermatitis herpetiformis (DH), atopic dermatitis, psoriasis, urticaria, and alopecia areata. Due to the insufficient availability of data, this study aimed to estimate the frequency of cutaneous manifestation in a Pakistani population with celiac disease. MethodsThis cross-sectional study was conducted from January 2020 to July 2021, and 300 patients with a confirmed diagnosis of celiac disease were enrolled in the study from the internal medicine department of a tertiary care hospital in Pakistan. Celiac disease was confirmed by the presence of immunoglobulin A (IgA) endomysial antibody and IgA tissue transglutaminase antibody. The presence of cutaneous manifestations was assessed with the assistance of a qualified dermatologist and noted in a self-structured questionnaire. ResultsOverall, the most common cutaneous manifestation was DH (16.0%), whereas the second most common cutaneous manifestation was psoriasis (13.8%). DH was most commonly found among males (18.9%), while psoriasis was more common among females (14.12%). ConclusionAmong the various cutaneous presentations in patients with celiac disease, the most common dermatological manifestation was DH. Therefore, patients with cutaneous manifestations should undergo screening for celiac disease.

Psoriasis, bone and bowel: a comprehensive review and new insights

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“…While IL-23 has a relatively consistent and unifying role in the pathogenesis of both psoriasis and IBD, inhibition of its downstream effector, namely IL-17A has led to different and paradoxical results in psoriasis and IBD [4]. For example, ustekinumab, a blocking agent of common subunit p40 of IL-12 and IL-23 showed effective inhibition of IL-12/IL-23 pathway and is now approved for plaque psoriasis, PsA, Crohn's disease and UC [16,26,27]. While IL-17 blocking agents, e.g., secukinumab and ixekizumab showed promising results in the treatment of psoriasis and PsA, they have the potential to exacerbate Crohn's disease [4].…”

Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels

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From Chilblains (Pernio) to Coeliac Disease—Should We Still Consider It Random?

“…Encouraged by this dermatological feature of CD, researchers are trying to correlate other dermatological and autoimmune diseases with CD, such as psoriasis, alopecia areata, chronic urticaria, cutaneous vasculitis, hereditary angioneurotic oedema and others, although without much success [ 4 , 10 ]. In a study by Dev et al, conducted on 300 coeliac disease patients, the most common skin manifestation of CD was dermatitis herpetiformis (16%), and the second was psoriasis (13.8%) [ 11 ]. To the best of our knowledge, there are only two published reports of chilblains associated with CD [ 12 , 13 ].…”