Frequency of CYP2C9 Genotypes among Omani Patients Receiving Warfarin and Its Correlation with Warfarin Dose

Abstract

Objectives: This study was conducted to determine the frequency of CYP2C9 alleles in Omani patients receiving warfarin and to correlate genotyping data with warfarin dosage. The Omani population has Asian and African ethnicities. Methods: CYP2C9 genotypes were determined by the polymerase chain reaction restriction fragment length polymorphism method. Non-parametric Kruskal-Wallis test was used to compare groups of continuous data for significance differences. Results: Genotyping data showed that 12.7 and 5.8% of the samples were heterozygous for the CYP2C9*2 and CYP2C9*3 alleles, respectively. The CYP2C9*2 allele frequency was 0.074 in our population. It was 0.029 for CYP2C9*3. Conclusion: This is the first report on the presence of CYP2C9*2 allele homozygocity in any Asian or African population.

Frequency of VKORC1 (C1173T) and CYP2C9 genetic polymorphisms in Egyptians and their influence on warfarin maintenance dose: proposal for a new dosing regimen

“…In agreement with our results, CYP2C9*1 is reported to be the most frequent allele in the Omani population [18], Americans [19] and British [20].…”

Genetic and Non-Genetic Factors Association with Warfarin Long Term Therapy Stability in Sudan

“…Figure 7. This result is unpredictably similar to those of Omani population, where minor allele frequency was markedly lower and was estimated at 7.4% 27 .…”

Distribution of the Major Cytochrome P450 (CYP) 2C9 Genetic Variants in a Saudi Population

“…, (2002) and Efrati et al. (2010) from Oman Egypt and Israel, respectively [21–23]. Interestingly, the allele frequencies of the CYP2C9*2 and *3 detected in the present study were 1.6‐ and 3.1 times higher than what was observed in Omanis [21].…”